Studies Directed Toward the Synthesis of the A-ring of Taxol PDF Download
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Author: Pauline McDonald Hamilton
Publisher:
ISBN:
Category : Cytochemistry
Languages : en
Pages : 164
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Book Description
Author: Pauline McDonald Hamilton
Publisher:
ISBN:
Category : Cytochemistry
Languages : en
Pages : 164
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Book Description
Author: Kamani Rupika Subasinghe
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 95
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Book Description
Author: James Lin
Publisher:
ISBN:
Category :
Languages : en
Pages : 264
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Book Description
Author: James D. Dudones
Publisher:
ISBN:
Category : Paclitaxel
Languages : en
Pages : 906
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Book Description
Author: Christopher Fairman Claiborne
Publisher:
ISBN: 9780591099461
Category : Aromatic compounds
Languages : en
Pages : 886
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Book Description
Model studies were carried out on key steps directed toward a synthesis of taxol. A model aromatic taxol C ring was coupled to taxol A ring via the Shapiro reaction. Selective functionalization of the A ring was carried out by epoxidation of the allylic alcohol derived from Shapiro coupling. Compatible protecting groups were found to rigidity the model AC framework in preparation for cyclization of the B ring. The McMurry reaction was established as an effective method for the formation of the eight membered B ring. Selective functionalization of the C-13 position of the A ring by PCC oxidation was accomplished. Controlled reduction of the C-13 ketone was carried out and subsequent coupling to the taxol side chain was achieve by the Oijima-Holton method. A biologically active analog of taxol was synthesized. Toward a synthesis of a brevetoxin B analog, a model ABC ring fragment was synthesized by established 6 -endo hydroxy-epoxide cyclizations. A model EF ring system was also synthesized by similar methods. Variations on the ABC fragment were independently coupled to the FG fragment and in a novel titanium mediated metathesis, the D ring was formed. Functionalization of the resulting D ring enol ether set the stage for the formation of the E ring via a hydroxy-ketone condensation. A hexacyclic (B - G) and heptacyclic (A - G) fused polyether ring systems were synthesized during our efforts to prepare a brevetoxin B analog.
Author: Jie Jack Li
Publisher: Springer Science & Business Media
ISBN: 3642340652
Category : Science
Languages : en
Pages : 292
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Book Description
'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Author: Matthew Suffness
Publisher: CRC Press
ISBN: 9780849383823
Category : Medical
Languages : en
Pages : 444
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Book Description
This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.
Author: Gordon M. Cragg
Publisher: CRC Press
ISBN: 1420039652
Category : Medical
Languages : en
Pages : 610
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Book Description
Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen
Author:
Publisher: Elsevier
ISBN: 0080499171
Category : Science
Languages : en
Pages : 433
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Book Description
The first three chapters of this latest volume, Annual Reports in Organic Synthesis (2003), are organised by reaction type. Later chapters deal with methods of synthesizing heterocyclic systems, the use of protecting groups and synthetically useful transformations. The final chapters deals with reviews and are divided by specific topics. - Clearly organised review of synthetically useful information. Emphasize on rapid visual retrieval - Extensive use of references - Beneficial to nearly all organic chemists, both specialists and nonspecialists in synthesis
Author: Hideji Itokawa
Publisher: CRC Press
ISBN: 0203381149
Category : Health & Fitness
Languages : en
Pages : 471
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Book Description
Taxol, originally derived from the North American Yew tree in 1971, is well-known worldwide as a powerful anticancer agent. Mechanistically, it has a unique microtubule stabilizing activity, and was clinically developed as a therapeutic agent in the treatment of breast and ovarian cancers at the National Cancer Institute, Washington D.C., USA. I
