Anatomy and Physiology

Anatomy and Physiology PDF Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0

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Book Description

Anatomy and Physiology

Anatomy and Physiology PDF Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0

Get Book Here

Book Description


Regulation of Gastrointestinal Mucosal Growth

Regulation of Gastrointestinal Mucosal Growth PDF Author: Rao N. Jaladanki
Publisher: Biota Publishing
ISBN: 1615047352
Category : Medical
Languages : en
Pages : 150

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Book Description
The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.

Gastrointestinal Anatomy and Physiology

Gastrointestinal Anatomy and Physiology PDF Author: John F. Reinus
Publisher: John Wiley & Sons
ISBN: 0470674849
Category : Medical
Languages : en
Pages : 210

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Book Description
Gastroenterologists require detailed knowledge regarding the anatomy of the GI system in order to understand the disturbances caused by diseases they diagnose and treat. Gastrointestinal Anatomy and Physiology will bring together the world’s leading names to present a comprehensive overview of the anatomical and physiological features of the gastrointestinal tract. Full colour and with excellent anatomical and clinical figures throughout, it will provide succinct, authoritative and didactic anatomic and physiologic information on all the key areas, including GI motility, hepatic structure, GI hormones, gastric secretion and absorption of nutrients. GI trainees will enjoy the self-assessment MCQs, written to the level they will encounter during their Board exams, and the seasoned gastroenterologist will value it as a handy reference book and refresher for re-certification exams

Anatomy & Physiology

Anatomy & Physiology PDF Author: Lindsay Biga
Publisher:
ISBN: 9781955101158
Category :
Languages : en
Pages :

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Book Description
A version of the OpenStax text

Colonic Motility

Colonic Motility PDF Author: Sushil K. Sarna
Publisher: Biota Publishing
ISBN: 1615041516
Category : Medical
Languages : en
Pages : 159

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Book Description
Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.

The Chemistry of Microbiomes

The Chemistry of Microbiomes PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309458390
Category : Science
Languages : en
Pages : 133

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Book Description
The 21st century has witnessed a complete revolution in the understanding and description of bacteria in eco- systems and microbial assemblages, and how they are regulated by complex interactions among microbes, hosts, and environments. The human organism is no longer considered a monolithic assembly of tissues, but is instead a true ecosystem composed of human cells, bacteria, fungi, algae, and viruses. As such, humans are not unlike other complex ecosystems containing microbial assemblages observed in the marine and earth environments. They all share a basic functional principle: Chemical communication is the universal language that allows such groups to properly function together. These chemical networks regulate interactions like metabolic exchange, antibiosis and symbiosis, and communication. The National Academies of Sciences, Engineering, and Medicine's Chemical Sciences Roundtable organized a series of four seminars in the autumn of 2016 to explore the current advances, opportunities, and challenges toward unveiling this "chemical dark matter" and its role in the regulation and function of different ecosystems. The first three focused on specific ecosystemsâ€"earth, marine, and humanâ€"and the last on all microbiome systems. This publication summarizes the presentations and discussions from the seminars.

Oxford Handbook of Gastrointestinal Nursing

Oxford Handbook of Gastrointestinal Nursing PDF Author: Christine Norton
Publisher: Oxford University Press, USA
ISBN: 0199298653
Category : Medical
Languages : en
Pages : 762

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Book Description
"This practical guide to all aspects of gastrointestinal nursing covers the treatment of a wide range of patients - from those suffering from minor and acute disorders, through chronic conditions, to those requiring major surgery and treatment for malignant disease. It summarizes the current state of knowledge in gastrointestinal nursing and provides concise, user-friendly guidelines on the management and treatment of patients with gastrointestinal disorders." "Written by practising nurses and subject experts, and incorporating their years of experience, the Oxford Handbook of Gastrointestinal Nursing is a unique and invaluable companion for practising nurses, and for all health care professionals who are involved in the care of patients with gastrointestinal disorders."--BOOK JACKET.

The Gastrointestinal Circulation

The Gastrointestinal Circulation PDF Author: Peter R. Kvietys
Publisher: Morgan & Claypool Publishers
ISBN: 1615041176
Category : Medical
Languages : en
Pages : 127

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Book Description
The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography

Concepts of Biology

Concepts of Biology PDF Author: Samantha Fowler
Publisher:
ISBN: 9781739015503
Category :
Languages : en
Pages : 0

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Book Description
Black & white print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy.

Fetal MRI

Fetal MRI PDF Author: Daniela Prayer
Publisher: Springer Science & Business Media
ISBN: 3540732713
Category : Medical
Languages : en
Pages : 531

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Book Description
This is the most comprehensive book to be written on the subject of fetal MRI. It provides a practical hands-on approach to the use of state-of-the-art MRI techniques and the optimization of sequences. Fetal pathological conditions and methods of prenatal MRI diagnosis are discussed by organ system, and the available literature is reviewed. Interpretation of findings and potential artifacts are thoroughly considered with the aid of numerous high-quality illustrations. In addition, the implications of fetal MRI are explored from the medico-legal and ethical points of view. This book will serve as a detailed resource for radiologists, obstetricians, neonatologists, geneticists, and any practitioner wanting to gain an in-depth understanding of fetal MRI technology and applications. In addition, it will provide a reference source for technologists, researchers, students, and those who are implementing a fetal MRI service in their own facility.