Structure and Retention in Chromatography PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Structure and Retention in Chromatography PDF full book. Access full book title Structure and Retention in Chromatography by Kaliszan. Download full books in PDF and EPUB format.
Author: Kaliszan
Publisher: CRC Press
ISBN: 9789057020285
Category : Science
Languages : en
Pages : 230
Get Book Here
Book Description
This book presents an update on the basics, trends and achievements of chemometric methodology required to study the relation between the chemical structure of solutes and their retention in various chromatographic systems. The author critically analyzes hundreds of relevant papers published during the past two decades. In this period, chemometrics has evolved into an established research and practice area of interest to scientists ranging from chromatographers to environmental and medicinal chemists. Although emphasis is placed on the more recent findings, readers will also find the basic theories required to solve specific problems. It should prove advantageous for contemporary chemists and related scientists if they switch from thermodynamics - in practice often inappropriate - to a statistically based (and limited) chemometric approach.
Author: Kaliszan
Publisher: CRC Press
ISBN: 9789057020285
Category : Science
Languages : en
Pages : 230
Get Book Here
Book Description
This book presents an update on the basics, trends and achievements of chemometric methodology required to study the relation between the chemical structure of solutes and their retention in various chromatographic systems. The author critically analyzes hundreds of relevant papers published during the past two decades. In this period, chemometrics has evolved into an established research and practice area of interest to scientists ranging from chromatographers to environmental and medicinal chemists. Although emphasis is placed on the more recent findings, readers will also find the basic theories required to solve specific problems. It should prove advantageous for contemporary chemists and related scientists if they switch from thermodynamics - in practice often inappropriate - to a statistically based (and limited) chemometric approach.
Author: Roman Kaliszan
Publisher: Wiley-Interscience
ISBN:
Category : Science
Languages : en
Pages : 328
Get Book Here
Book Description
The use of computers in numerical characterization of molecular structures has given chemists fundamentally new information on chemical structures, leading to major developments in physical, analytical, and medicinal chemistry. This book, written by a pioneer in the field, extends and updates research on quantitative structure retention relationships (QSRR) by consolidating and critically reviewing the extensive literature on the subject while providing basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Coverage includes detailed discussions of the general theories and mechanisms of chromatographic separations, prediction of retention coefficients, statistical techniques and formal requirements of QSRR studies, specific applications of chromatographic data, and much more. Also provides several carefully selected figures and tables plus extensive bibliographies.
Author: R. Kaliszan
Publisher: Elsevier Inc. Chapters
ISBN: 0128071443
Category : Science
Languages : en
Pages : 34
Get Book Here
Book Description
In view of linear free-energy relationships, LFER, chromatographic systems are “free-energy transducers,” translating differences in the structure of analytes into quantitative differences in physicochemical properties, like retention parameters. Hence, quantitative structure property (retention) relationships, QSP(R)R, bear valuable information on analytes and the separation systems involved. We illustrate here what can be achieved from the statistically valid and physically meaningful quantitative structure-retention relationships, QSRR. In particular, one can predict retention data, confirm identification, and optimize conditions of separation of given structurally defined analytes. Also, QSPR can shed light on the molecular mechanism of separation operating on specific stationary phases. Additionally, one can assess such properties of drug analytes of pharmacokinetic importance, like lipophilicity and acidity. Also, differences in interactions of xenobiotics with biomacromolecule components of chromatographic systems can conveniently be quantified. By means of QSRR, the chromatographic behavior of analytes in diverse separation systems can be related to their pharmacological properties.
Author: Satinder Ahuja
Publisher: Elsevier
ISBN: 0080455182
Category : Medical
Languages : en
Pages : 679
Get Book Here
Book Description
High pressure liquid chromatography–frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening). A complete reference guide to HPLC Describes best practices in HPLC and offers 'tricks of the trade' in HPLC operation and method development Reviews key HPLC pharmaceutical applications and highlights currents trends in HPLC ancillary techniques, sample preparations, and data handling
Author: Yuri V. Kazakevich
Publisher: John Wiley & Sons
ISBN: 0470087943
Category : Science
Languages : en
Pages : 1136
Get Book Here
Book Description
HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.
Author: R.M. Smith
Publisher: Elsevier
ISBN: 0080858651
Category : Science
Languages : en
Pages : 479
Get Book Here
Book Description
This book brings together a number of studies which examine the ways in which the retention and selectivity of separations in high-performance liquid chromatography are dependent on the chemical structure of the analytes and the properties of the stationary and mobile phases. Although previous authors have described the optimisation of separations by alteration of the mobile phase, little emphasis has previously been reported of the influence of the structure and properties of the analyte. The initial chapters describe methods based on retention index group increments and log P increments for the prediction of the retention of analytes and the ways in which these factors are influenced by mobile phases and intramolecular interactions. The values of a wide range of group increments in different eluents are tabulated. Different scales of retention indices in liquid chromatography are described for the comparison of separations, the identification of analytes and the comparison of stationary phases. Applications of these methods in the pharmaceutical, toxicology, forensic, metabolism, environmental, food and other fields are reviewed. The effects of different mobile phases on the selectivity of the retention indices are reported. A compilation of sources of reported retention index values are given. Methods for the comparison of stationary phases based on the interactions of different analytes are covered, including lipophilic and polar indices, shape selectivity comparisons, their application to novel stationary phases, and chemometric methods for column comparisons.
Author: Serban C. Moldoveanu
Publisher: Elsevier
ISBN: 0323998364
Category : Science
Languages : en
Pages : 718
Get Book Here
Book Description
Essentials in Modern HPLC Separations, Second Edition discusses the role of separation in high performance liquid chromatography (HPLC). This new and updated edition systematically presents basic concepts as well as new developments in HPLC. Starting with a description of basic concepts, it provides important guidance for the practical utilization of various HPLC procedures, such as the selection of the HPLC type, proper choice of the chromatographic column, selection of mobile phase and selection of the method of detection, all of which are in correlation with the physico-chemical characteristics of the compounds separated. Every chapter has been carefully reviewed, with several new sections added to bring the book completely up-to-date. Hence, it is a valuable reference for students and professors in chemistry. Provides a thoroughly updated resource, with an entirely new section on Computer-aided Method Development in HPLC and new subsections on miniaturization and automation in HPLC, chemometric aspects of HPLC, green solvent use in HPLC, and more Includes insights into the chromatographic process to find the optimum solution for analyzing complex samples Presents a basis for understanding the utilization of modern HPLC for applications, particularly for the analysis of pharmaceutical, biological, food, beverage and environmental samples
Author: Emelita D. Breyer
Publisher:
ISBN:
Category :
Languages : en
Pages : 390
Get Book Here
Book Description
Author: T A Berger
Publisher: Royal Society of Chemistry
ISBN: 1847551602
Category : Science
Languages : en
Pages : 268
Get Book Here
Book Description
Packed Column SFC is the third title to be published in this series and has been produced as a result of the dramatic re-emergence, in the last three years, of packed column instrumentation. This has led to a redefinition of the technique and an urgent need for a practical guide that deals with its subtleties. This book fulfils that need and deals exclusively with packed column SFC. It places the emphasis on understanding the underlying chemistry in order to perform rapid, systematic optimizations and provides many practical tips to help the new user avoid problems unique to SFC. It also proposes a detailed scheme for method development and provides lists of prioritized guidelines. The book clears up some of the confusion that surrounds the analytical use of supercritical fluids and assists the user in understanding the power and utility of this technique. Detailed chapters cover the most promising new application areas for packed column SFC, which are often overlooked in the mainstream chromatography literature. Like the other books in this popular series, Packed Column SFC will prove an invaluable guide and is essential reading for graduates, postgraduates and researchers with interests in pharmaceuticals, agricultural chemistry, small polar drug molecules, chiral analysis, environmental chemistry, and chromatography/instrumentation.
Author: Yuen Ting Fong
Publisher:
ISBN:
Category : High performance liquid chromatography
Languages : en
Pages : 220
Get Book Here
Book Description
