Structural Studies of the Human DNA Polymerase Kappa PDF Download
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Author: Sacha N. Uljon
Publisher:
ISBN:
Category :
Languages : en
Pages : 101
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Author: Sacha N. Uljon
Publisher:
ISBN:
Category :
Languages : en
Pages : 101
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Author: Ajay Ummat
Publisher:
ISBN:
Category :
Languages : en
Pages : 121
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Author: Karl. E. Zahn
Publisher:
ISBN:
Category :
Languages : en
Pages : 336
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Chapter 5 represents a work in progress, providing an overview of our continuing efforts to model human DNA polymerase [theta] (hPOLQ), a specialized polymerase overexpressed in breast cancer cells, among others. By solving a 3.9Å crystal structure, we have already obtained an atomic resolution glimpse of the polymerase active site. This dissertation concludes in chapter 6 with the strategies we will be applying in the near future to extend the resolution of our polymerase [theta] model and compose the next round of questions in the area of research.
Author: Timothy David Silverstein
Publisher:
ISBN:
Category :
Languages : en
Pages : 169
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Author: Francis Mwai Kariuki
Publisher:
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Category :
Languages : en
Pages : 166
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Author: Barry Jon Coull
Publisher:
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Category :
Languages : en
Pages : 412
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Author: Giovanni Maga
Publisher: World Scientific
ISBN: 9813226420
Category : Science
Languages : en
Pages : 398
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Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes.
Author:
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ISBN:
Category :
Languages : en
Pages : 412
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Author: Fang Li
Publisher:
ISBN:
Category :
Languages : en
Pages : 260
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Author: Assen Gueorguiev Marintchev
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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