Structural and Functional Aspects of Enzyme Catalysis PDF Download
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Author: Gesellschaft fur Biologische Chemie
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages :
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Book Description
Author: Gesellschaft fur Biologische Chemie
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages :
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Book Description
Author: H. Eggerer
Publisher: Springer Science & Business Media
ISBN: 3642817386
Category : Science
Languages : en
Pages : 221
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Book Description
Enzymes perform the executive role in growth, energy conversion, and repair of a living organism. Their activity is adjusted to their en vironment within the cell, being turned off, switched on, or finely tuned by specific metabolites according to demands at the physiologi cal level. Each enzyme discovered in the long history of enzymology has revealed its own individuality. Even closely related members of a family differ in specificity, stability or regulatory properties. Despite these, at first sight overwhelming aspects of individuality, common factors of enzymic reactions have been recognized. Enzymes are stereospecific catalysts even when a nonspecific process would yield the same product. Knowledge of the detailed stereochemistry of an enzymic reaction helps to deduce reaction mechanisms and to ob tain insight into the specific binding of substrates at the active site. This binding close to catalytically competent groups is related to the enormous speed of enzyme-catalyzed reactions. The physical ba sis of rate-enhancement is understood in principle and further exploit ed in the design of small organic receptor molecules as model enzymes. These aspects of enzyme catalysis are discussed in Session 1. Session 2 emphasizes the dynamic aspects of enzyme substrate inter action. Substrate must diffuse from solution space to the enzyme's surface. This process is influenced and can be greatly facilitated by certain electrostatic propterties of enzymes. The dynamic events during catalysis are studied by relaxation kinetics or NMR techniques.
Author: H. Eggerer
Publisher: Springer
ISBN: 9783540111108
Category : Science
Languages : en
Pages : 218
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Book Description
Enzymes perform the executive role in growth, energy conversion, and repair of a living organism. Their activity is adjusted to their en vironment within the cell, being turned off, switched on, or finely tuned by specific metabolites according to demands at the physiologi cal level. Each enzyme discovered in the long history of enzymology has revealed its own individuality. Even closely related members of a family differ in specificity, stability or regulatory properties. Despite these, at first sight overwhelming aspects of individuality, common factors of enzymic reactions have been recognized. Enzymes are stereospecific catalysts even when a nonspecific process would yield the same product. Knowledge of the detailed stereochemistry of an enzymic reaction helps to deduce reaction mechanisms and to ob tain insight into the specific binding of substrates at the active site. This binding close to catalytically competent groups is related to the enormous speed of enzyme-catalyzed reactions. The physical ba sis of rate-enhancement is understood in principle and further exploit ed in the design of small organic receptor molecules as model enzymes. These aspects of enzyme catalysis are discussed in Session 1. Session 2 emphasizes the dynamic aspects of enzyme substrate inter action. Substrate must diffuse from solution space to the enzyme's surface. This process is influenced and can be greatly facilitated by certain electrostatic propterties of enzymes. The dynamic events during catalysis are studied by relaxation kinetics or NMR techniques.
Author: Gorden Hammes
Publisher: Elsevier
ISBN: 032315817X
Category : Science
Languages : en
Pages : 276
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Book Description
Enzyme Catalysis and Regulation is an introduction to enzyme catalysis and regulation and covers topics ranging from protein structure and dynamics to steady-state enzyme kinetics, multienzyme complexes, and membrane-bound enzymes. Case studies of selected enzyme mechanisms are also presented. This book consists of 11 chapters and begins with a brief overview of enzyme structure, followed by a discussion on methods of probing enzyme structure such as X-ray crystallography and optical spectroscopy. Kinetic methods are then described, with emphasis on the general principles of steady-state and transient kinetics. The chemical principles involved in enzyme catalysis are also discussed, and case studies of a few well-documented enzymes are presented. The regulation of enzyme activity is analyzed from a nongenetic viewpoint, with particular reference to binding isotherms and models for allosterism. Two particular enzymes, aspartate transcarbamoylase and phosphofructokinase, are used as examples of well-studied regulatory enzymes. The last two chapters focus on multienzyme complexes and membrane-bound enzymes. This monograph is intended for graduate students, advanced undergraduates, and research workers in molecular biology and biochemistry.
Author: Hermann Eggerer
Publisher:
ISBN:
Category :
Languages : de
Pages : 0
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Author: Toshio Fukui
Publisher: Wiley-Blackwell
ISBN: 9783527300174
Category : Science
Languages : en
Pages : 0
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Book Description
Recent expansion in the range and sophistication of techniques in protein science has provided a wealth of new information. This book deals with the latest achievements by the most active researchers in the field of enzyme catalysis. Twenty-eight authors from Japan, the USA and Israel provide first-class information on enzyme structure and function studies. Their ideas for new methodologies will stimulate the redesign of more effective biocatalysts. A discussion of new trends, and advanced techniques is followed by detailed presentations of the structures and functions of such important enzymes as: - Aspartate Aminotransferase - Tryptophan Synthase - Alanine Racemase - Tryptophanase - Superoxid Dismutase - H+-ATPas
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Sidney A. Bernhard
Publisher:
ISBN:
Category : Enzymes
Languages : en
Pages : 340
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Book Description
Author: Dominic W.S. Wong
Publisher: Springer Science & Business Media
ISBN: 9780412056918
Category : Science
Languages : en
Pages : 416
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Book Description
Food Enzymes: Structure and Mechanism is the first volume to bring together current information on the structures and mechanisms of important food enzymes. It provides an in-depth discussion of the dynamic aspects of enzyme structures and their relationship to the chemistry of catalysis. The book emphasizes aspects of the chemistry of enzyme structure and mechanism seldom covered in the food science literature. It includes a thorough discussion of the genetic modification of enzyme structures and functions with reference to specific food enzymes. More than 100 illustrations enhance the clarity of important concepts. Comprehensive references reflect the current state of knowledge on enzyme actions.
Author: Haruo Suzuki
Publisher: CRC Press
ISBN: 1000681432
Category : Medical
Languages : en
Pages : 222
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Book Description
The first edition of this book covered the basic treatment of the enzyme reaction using the overall reaction kinetics and stopped-flow method, the general properties of protein and cofactors, the control of enzyme reaction, and the preparation of enzyme protein. These topics are the basis of enzyme research and thus suitable for the beginner in the field. The second edition presents the cofactors produced via the post-translational modification of the enzyme’s active site. These cofactors expand the function of enzymes and open a new research field. The carbonyl reagent phenylhydrazine and related compounds have been useful in finding some of the newly discovered cofactors and thus have been discussed in this edition. The topic of the control of enzyme activity through the channel of substrates and products in polyfunctional enzymes has also been expanded in this book.
