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Author: Francois Ferre
Publisher: Springer Science & Business Media
ISBN: 1461241642
Category : Medical
Languages : en
Pages : 379
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Book Description
Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population.
Author: Francois Ferre
Publisher: Springer Science & Business Media
ISBN: 1461241642
Category : Medical
Languages : en
Pages : 379
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Book Description
Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population.
Author: Social Science Research Council (U.S.). Committee on States and Social Structures
Publisher: Cambridge University Press
ISBN: 9780521313131
Category : Political Science
Languages : en
Pages : 406
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Book Description
Papers from a conference held at Mount Kisco, N.Y., Feb. 1982, sponsored by the Committee on States and Social Structures, the Joint Committee on Latin American Studies, and the Joint Committee on Western European Studies of the Social Science Research Council. Includes bibliographies and index.
Author: Mizeck Chagunda
Publisher: MDPI
ISBN: 3039285300
Category : Science
Languages : en
Pages : 168
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Book Description
Ruminants contribute significantly to human food security. However, the production of ruminants contributes to greenhouse gas (GHG) emissions that are responsible for climate change. GHGs such as methane, carbon dioxide, and nitrous oxide are produced from different processes of ruminant production. Ruminant enteric methane is a substantial component of methane produced by agriculture. This book presents novel and established methods in quantifying and reducing enteric methane emission from ruminants in different production systems. The book covers different types of ruminants including cattle, sheep, and goats. The chapters are contributed by scientists and authors from different parts of the world, demonstrating the importance of this problem and the universal drive for immediate and sustainable solutions. Although, biologically speaking, the production of enteric methane cannot be reduced to zero, high emissions are an indicator of inefficient digestion of feed in the rumen and low utilisation of feed energy. By presenting research that could lead to robust and yet practical quantification methods and mitigation strategies, this book not only contributes to the discourse and new knowledge on the magnitude of the problem but also brings forward potential solutions in different livestock production systems.
Author: Juha-Antti Lamberg
Publisher: Springer Science & Business Media
ISBN: 9781402065675
Category : Business & Economics
Languages : en
Pages : 332
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Book Description
An analysis of the evolution of competitive strategies within the forestry industry is presented in this book. The argument is that the chosen context serves as an illustrative setting for a discussion related to global corporate evolution. Therefore, this analytical and rigorous book contributes to better understanding of the workings of a number of manufacturing industries through discussion of the evolutionary development within the pulp and paper industry.
Author: Robert Pardo
Publisher: John Wiley & Sons
ISBN: 111804505X
Category : Business & Economics
Languages : en
Pages : 334
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Book Description
A newly expanded and updated edition of the trading classic, Design, Testing, and Optimization of Trading Systems Trading systems expert Robert Pardo is back, and in The Evaluation and Optimization of Trading Strategies, a thoroughly revised and updated edition of his classic text Design, Testing, and Optimization of Trading Systems, he reveals how he has perfected the programming and testing of trading systems using a successful battery of his own time-proven techniques. With this book, Pardo delivers important information to readers, from the design of workable trading strategies to measuring issues like profit and risk. Written in a straightforward and accessible style, this detailed guide presents traders with a way to develop and verify their trading strategy no matter what form they are currently using–stochastics, moving averages, chart patterns, RSI, or breakout methods. Whether a trader is seeking to enhance their profit or just getting started in testing, The Evaluation and Optimization of Trading Strategies offers practical instruction and expert advice on the development, evaluation, and application of winning mechanical trading systems.
Author: Kook-Hee Gil
Publisher: Oxford University Press
ISBN: 0199692432
Category : Language Arts & Disciplines
Languages : en
Pages : 337
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Book Description
Quantification has been at the heart of research in the syntax and semantics of natural language since Aristotle. The last few decades have seen an explosion of detailed studies of the syntax and semantics of quantification and its relation to the rest of the theory of grammar, resulting in a highly sophisticated understanding of the mechanisms of quantification. This book considers the ways natural languages vary with respect to their realisation of quantificational notions. Drawing on data from English, German, Japanese, Korean, Mandarin, Hausa and others, the authors also link the variation in the expression of quantification to the notions of polarity sensitivity, free-choice and indefiniteness.
Author: Harry R. Yarger
Publisher: DIANE Publishing
ISBN: 1428916229
Category : Military doctrine
Languages : en
Pages : 93
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Book Description
Author: Nir Piterman
Publisher: Springer
ISBN: 3642367429
Category : Computers
Languages : en
Pages : 669
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Book Description
This book constitutes the proceedings of the 19th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, TACAS 2013, held in Rome, Italy, in March 2013. The 42 papers presented in this volume were carefully reviewed and selected from 172 submissions. They are organized in topical sections named: Markov chains; termination; SAT/SMT; games and synthesis; process algebra; pushdown; runtime verification and model checking; concurrency; learning and abduction; timed automata; security and access control; frontiers (graphics and quantum); functional programs and types; tool demonstrations; explicit-state model checking; Büchi automata; and competition on software verification.
Author: Thomas Prohaska
Publisher: Royal Society of Chemistry
ISBN: 1849735409
Category : Science
Languages : en
Pages : 667
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Book Description
This book was triggered by the success story of sector field mass spectrometry in elemental and isotopic analysis from the early days when the first mass spectrum of Ne was presented a hundred years ago. The outstanding and unique features of sector field mass spectrometry - high sensitivity, high mass resolution and simultaneous multiple ion detection - paved the way for its successful and increasing application in different fields of science. Written, compiled and edited by worldwide renowned experts with profound expertise in sector field mass spectrometry related to elemental and isotopic analysis, this book is intended to provide deep insight into the topic along with fundamental knowledge about elemental and isotopic analysis. Aimed at scientists in the field of natural and life sciences, instrument manufacturers, practitioners and graduate students, this book provides solid information about the methodological background and analytical capabilities of sector field mass spectrometry. A detailed description of peculiarities and an overview of the most relevant applications making use of specific techniques using sector field mass analysers (ICP-MS, GDMS, TIMS, SIMS and IRMS) are given, including a presentation of the currently available commercial instruments. This approach guarantees that readers are thoroughly introduced to and familiarized with the fascinating inter- and transdisciplinary field of sector field mass spectrometry.
Author: Paulo Eduardo Sichetti Munekata
Publisher: Elsevier
ISBN: 0443189765
Category : Medical
Languages : en
Pages : 446
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Book Description
Application of Emerging Technologies and Strategies to Extract Bioactive Compounds, Volume Three in the Developments in Food Quality and Safety series, is the most up-to-date resource covering trend topics such as advances in the analysis of toxic compounds and control of food poisoning, food fraud, traceability and authenticity, revalorization of agrifood industry, natural antimicrobial compounds and application to improve the preservation of food, non-thermal processing technologies in the food industry, nanotechnology in food production, and Intelligent packaging and sensors for food applications. Chapters in this release explore the latest developments in the application of each technology, such as ultrasound, microwave, high-pressure, pulsed electric fields, ohmic, uv and ir heating, extrusion, and solar energy assisted extractions, along with membrane technologies and alternative solvents for green extraction. The series is edited by Dr. José Manuel Lorenzo and authored by a team of global experts in the field. - Thoroughly explains the technologies applied in the extraction of bioactive compounds from different sources - Covers the fundamentals and latest developments for each technology, along with the main bioactive compounds - Discusses, in detail, the aspects of extraction technologies and strategies to obtain extracts rich in bioactive compounds
