Author: Roshni Iyer
Publisher:
ISBN:
Category : Drug delivery systems
Languages : en
Pages : 114
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Book Description
Despite extensive research and progress in anti-cancer therapeutics, an effective treatment for nonsmall cell lung cancer (NSCLC) remains elusive, resulting in poor 5-year patient survival rate.Towards this end, we have explored a therapeutic regimen to improve the effects of local concurrent chemo-radiation-therapy (CRT), by utilizing multifunctional stimuli-responsive nanoparticles (NPs) as drug carriers. We have also utilized lung cancer targeting strategies for site specific drug delivery, mainly antibodies against the Ephrin-transmembrane receptor kinase (EphA2), that is over-expressed mainly on lung cancer cells, to promote the targeted delivery of drugs to only cancer cells, and eventually reduce the toxicity to healthy tissues. The overall goal of these NPs is to provide a triggered release of potent radiosensitizers (NU7441) upon exposure to radiation, followed by release of chemotherapeutic agents (cisplatin) in response to elevated glutathione levels in the lung cancer cells, to facilitate enhanced spatio-temporal drug release in the lung tumor environment for CRT. This design-driven research has been approached in three specific aims, each exploring the physico-chemical properties of the NPs and their in vitro and in vivo therapeutic efficacies and biodistribution; Aim 1: Cisplatin-loaded glutathione (GSH)-responsive nanoparticles (GNPs) for lung cancer chemotherapy, Aim 2: NU7441-loaded radiation(RT)-responsive NPs for lung cancer radiation therapy and Aim 3: Multifunctional dual drug loaded, dual stimuli-responsive core-shell NPs (DSNPs) for CRT. Our results demonstrated the GSH- and radiation-responsive drug release characteristics of the NPs from Aim 1 and 2 respectively, the enhanced lung cancer cell targeting abilities of these NPs and finally their improved therapeutic efficacies compared to free drugs and untargeted NPs. Finally, a core-shell combination of these NPs observed synergistic drug release and therapeutic efficacies, concurrently with radiation therapy. These NPs could potentially be used to improve outcomes in patients with NSCLC when applying CRT to treat lung cancer.
Author: Saji Uthaman
Publisher: Frontiers Media SA
ISBN: 2889740021
Category : Science
Languages : en
Pages : 148
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Book Description
Author: Ramesh Marasini
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Small molecule anticancer drugs are the first-line therapy used in clinical cancer management which has shown success in the killing of rapidly dividing cancer cells. However, nonspecific distribution of these small molecular therapeutics has adverse side effects reducing the quality of life. Therefore, in the past few decades, massive interest and investment have been given in cancer nanomedicine with the hope to reduce drug-associated toxicity by targeting cancer cells in a heterogeneous tumor environment. Nanomedicine is the drug-containing nanostructured construct with a large surface-to-volume ratio, which has plenty of room to load drugs and other necessary constituents to design it as target-specific. Towards the endeavor of precise anticancer drug delivery to tumors, significant efforts have been given to obtain an optimized nanocarrier system to co-operate or bypass biological barriers further advancing the therapeutic and diagnostic efficiency of drugs. The main objective of this dissertation is to explore the different strategies of nanomaterials for drug delivery via light-triggered and magnet sensitive design considerations discussed in chapter 1. The synthesized nanomaterials were extensively studied and evaluated for their chemistry and biological functions for in vitro cancer therapy and in vivo diagnosis. In chapter 2, we developed the optimum surfactant packing strategy for light-responsive gold nanoparticles (NPs) for photothermal therapy (PTT) of melanoma. Results showed that 5 kDa polyethylene glycol (PEG) coated gold nanorod provided the highest colloidal stability and maximum photothermal efficiency compared to the low (2 kDa) and high mass of PEG (10 kDa) used when treated with near-infrared (NIR) laser. Taking one step further, in chapter 3, we encapsulated NIR light-responsive indocyanine class of dye (IR-820) into polymeric NPs for the PTT of breast cancer. The optical properties of dye were preserved to obtain better photothermal efficiency than free IR-820 at an equivalent concentration of dye after laser treatment. Moreover, the molecular mechanism of PTT revealed that the dye loaded NPs inducedcell death primarily through apoptosis, a preferred cell-death pathway over necrosis. In chapter 4, we designed peptide conjugated lipid-polymer NPs for p32 targeted drug delivery and tracked NIR dye-labeled NPs in vivo using an optical imaging system. The targeted NPs were accumulated 2-fold higher than non-targeted counterparts in the murine osteosarcoma model suggesting the diagnostic potential of targeted NPs. In chapter 5, we developed magnet responsive iron chelated paramagnetic polymeric NPs with high colloidal stability and longitudinal relaxivity of 10.5 mM−1s−1 as compared to the Magnevist® 3.98 mM−1s−1 (a clinical gadolinium contrast agent) and enhanced contrast efficacy in vivo at clinical magnetic resonance imaging (3 T) system showing its promise as a blood pool contrast agent in disease detection. The nanoconstructs described herein addresses the current limitations of conventional nanoparticles via different design considerations. The significant findings such as targeted drug delivery with improved therapeutic and diagnostic efficacy of each system are highlighted and discussed throughout the dissertation. These results could open the avenues for systemic investigations and lay the foundation for the design of cancer nanomedicine to accelerate clinical translation.
Author: Amit Singh
Publisher: Royal Society of Chemistry
ISBN: 1788014669
Category : Technology & Engineering
Languages : en
Pages : 376
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Book Description
The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.
Author: Kamal Dua
Publisher: Elsevier
ISBN: 0323900798
Category : Business & Economics
Languages : en
Pages : 572
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Book Description
Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
Author: Anil K. Sharma
Publisher: CRC Press
ISBN: 135136068X
Category : Medical
Languages : en
Pages : 406
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Book Description
With chapters from highly skilled, experienced, and renowned scientists and researchers from around the globe, Dendrimers for Drug Delivery provides an abundance of information on dendrimers and their applications in the field of drug delivery. The volume begins with an introduction to dendrimers, summarizing dendrimer applications and the striking features of dendrimers. It goes on to present the details of usual properties, structure, classification, and methods of synthesis, with relevant examples. The toxicity of dendrimers is also discussed. The chapter authors provide an exhaustive amount of information about dendrimers and their biomedical applications, including biocompatibility and toxicity aspects, a very useful feature. This informative volume will be valuable resource that will help readers to create products derived from dendrimers and navigate through the regulatory, manufacturing, and quality control hurdles. It will be an important resource for researchers, scientists, upper-level students, and industry professionals.
Author: Ye Liu
Publisher: CRC Press
ISBN: 0429767870
Category : Science
Languages : en
Pages : 385
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Book Description
Polymers are one of the most versatile and important materials used for capsule preparation despite various others available. Suitably formulated capsules can securely protect ingredients, deliver them to targeted sites, and release them expeditiously, improving functions and minimizing adverse effects. New polymers are constantly being explored to develop more efficient capsules as they are routinely used in pharmaceuticals, consumer healthcare products, nutrients, and food. This book focuses on the current state of the art of polymer-based capsules and delivery systems. It describes the formulation processes of capsules developed from redox-responsive polymers and polymer-functionalized carbon nanotubes, in addition to shedding light on coacervation of polymers for encapsulation. It reviews different active ingredients that can be used with polymer capsules in various products, encapsulation of essential oils using such capsules, and development of polymer capsules of cells and bacteriophages.
Author: Abdel Salam Hamdy Makhlouf
Publisher: Woodhead Publishing
ISBN: 0081019963
Category : Technology & Engineering
Languages : en
Pages : 637
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Book Description
Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications: Volume Two: Advanced Nanocarriers for Therapeutics discusses, in detail, the recent trends in designing dual and multi-responsive polymers and nanoparticles for safe drug delivery. Chapters cover dual-responsive polymeric nanocarriers for drug delivery and their different stimuli, multi-responsive polymeric nanocarriers, and the therapeutic applications of stimuli-responsive polymers. With an emphasis on advanced medical applications and synergistic operational and technological methodologies for the improvement of polymers systems for the production of stimuli-responsive polymers, this book is essential reading for materials scientists and researchers working in the drug delivery and pharmaceutical industries. As innovation and development in the area of stimuli responsive polymer-based nanomaterials for drug delivery is moving fast and there is an increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery, users will find this to be a timely resource. Focusses on the most advanced technologies, recent evaluation methods, technical aspects, and advanced synthesis techniques stimuli-responsive polymers Examines advanced medical applications of stimuli responsive polymers Analyzes synergistic operational and technological methodologies for the improvement of polymer systems for the production of stimuli-responsive polymers in drug delivery
Author: Daudi Nyangaresi
Publisher: Grin Publishing
ISBN: 9783668260641
Category :
Languages : en
Pages : 20
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Book Description
Essay from the year 2016 in the subject Biology - Diseases, Health, Nutrition, language: English, abstract: This paper seeks to explore the development of proper drug delivery systems (DDS). In doing this, the researcher will look at a wide range of various other types of cancers and the various DDS's used to create a better one on the basis of set criteria including type of nanocarrier, effective delivery, shrinkage of tumor, distribution of drug, biocompatibility/chemical reactivity and lastly possible side effects. Previously, DDS's took into consideration variety drug delivery systems including inhalable magnetic nanoparticles, hyaluronic acid-ceramide nanoparticles, personalized polypropylenimine (PPI) dendrimer, and stimuli-responsive clustered nanoparticles [12]-[15]. In the present study, the tactic of the DDS will encompass a hybrid constitution of numerous nanocarriers types that will be at the minimum of dual layers. The utilization of nanotechnology in medicine has necessitated the creation of functionalized nanoparticles that can be utilized as carriers. Nanotechnology enables loading of the particles with drugs for delivery to specific locations in the body in a tightly controlled manner. As much as nanomedicine is quite new in the medical industry, some nanocarriers designed specifically for drug delivery have been in use for the past three decades.
Author: Challa S. S. R. Kumar
Publisher: Wiley-VCH
ISBN:
Category : Medical
Languages : en
Pages : 448
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Book Description
This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.
