Sites of Action for Neurotoxic Pesticides PDF Download
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Author: Robert M. Hollingworth
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 352
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Book Description
Annotation Developed from a symposium at the 191st Meeting of the American Chemical Society, New York, New York, April 1987. The war against pests has intensified as pest resistance, degradation in soils, and development of new technologies reduce the number of chemicals available for use. Writings in this work document the effectiveness of insecticides on various target sites and examine the nervous system as the major battleground for current and future insecticides. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com).
Author: Robert M. Hollingworth
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 352
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Book Description
Annotation Developed from a symposium at the 191st Meeting of the American Chemical Society, New York, New York, April 1987. The war against pests has intensified as pest resistance, degradation in soils, and development of new technologies reduce the number of chemicals available for use. Writings in this work document the effectiveness of insecticides on various target sites and examine the nervous system as the major battleground for current and future insecticides. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com).
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309166411
Category : Science
Languages : en
Pages : 226
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Book Description
The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.
Author: M. G. Ford
Publisher: John Wiley & Sons
ISBN:
Category : Medical
Languages : en
Pages : 518
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Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309045312
Category : Science
Languages : en
Pages : 167
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Book Description
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Author: D. Shankland
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 304
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Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309048753
Category : Science
Languages : en
Pages : 402
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Book Description
Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309036879
Category : Nature
Languages : en
Pages : 476
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Book Description
The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.
Author: Isaac Ishaaya
Publisher: Springer Science & Business Media
ISBN: 3642595499
Category : Science
Languages : en
Pages : 353
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Book Description
In recent years many of the conventional methods of insect control by broad spectrum synthetic chemicals have come under scrutiny because of their unde sirable effects on human health and the environment. In addition, some classes of pesticide chemistry, which generated resistance problems and severely affected the environment, are no longer used. It is against this background that the authors of this book present up-to-date findings-relating to biochemical sites that can serve as targets for developing insecticides with selective prop erties, and as the basis for the elucidation of resistance mechanisms and countermeasures. The book consists of eight chapters relating to biochemical targets for insec ticide action and seven chapters relating to biochemical modes of resistance and countermeasures. The authors of the chapters are world leaders in pesti cide chemistry, biochemical modes of action and mechanisms of resistance. Biochemical sites such as chitin formation, juvenile hormone and ecdysone receptors, acetylcholine and GABA receptors, ion channels, and neuropeptides are potential targets for insecticide action. The progress made in recent years in molecular biology (presented in depth in this volume) has led to the iden tification of genes that confer mechanisms of resistance, such as increased detoxification, decreased penetration and insensitive target sites. A combina tion of factors can lead to potentiation of the resistance level. Classifications of these mechanisms are termed gene amplification, changes in structural genes, and modification of gene expression.
Author: Donald J. Ecobichon
Publisher: CRC Press
ISBN: 9781439805459
Category : Medical
Languages : en
Pages : 408
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Book Description
Since the publication of the original edition in 1982, pesticide-related poisonings, both single cases and epidemic-scale situations, have continued to occur unabated. This new edition of Pesticides and Neurological Diseases reviews current literature describing the effects of insecticides (chlorinated hydrocarbons, organophosphorus and carbamate e
Author: J. Routt Reigart
Publisher: DIANE Publishing
ISBN: 1437914527
Category : Technology & Engineering
Languages : en
Pages : 238
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Book Description
This 5th ed. is an update and expansion of the 1989 4th ed. This EPA manual provides health professionals with information on the health hazards of pesticides currently in use, and current consensus recommendations for management of poisonings and injuries caused by them. As with previous updates, this new ed. incorporates new pesticide products that are not necessarily widely known among health professionals. Contents: (1) General Information: Introduction; General Principles in the Management of Acute Pesticide Poisonings; Environmental and Occupational History; (2) Insecticides; (3) Herbicides; (4) Other Pesticides; (5) Index of Signs and Symptoms; Index of Pesticide Products. Charts and tables.
