Author: Charles Herbert Best
Publisher: University of Toronto Press
ISBN: 1442633603
Category : Medical
Languages : en
Pages : 1187
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Book Description
The name of Charles H. Best, co-discoverer of insulin, Head of the Department of Physiology and Director of the Banting and Best Department of Medical Research in the University of Toronto, is familiar to medical and lay readers all over the world. The story of his early insulin research with Dr. Frederick Banting, as a result of which men and women and children who forty years ago would have had only months or days to live are now spared, has been one of the most dramatic in the annals of medicine. This volume records the achievements of forty years of medical research, giving direct and easy access to over sixty of Dr. Best’s original important research papers in the fields particularly of insulin, heparin, and choline. It opens with the early papers describing the discovery of insulin, and continues with those dealing with its preparation, extraction, physiologic effects and first clinical applications. Dr. Best has also looked back over the record as given in these papers and provided informative and informal bridges between them which place them in historical perspective. Among medical scientists Dr. Best is equally well known for initiating and developing modern knowledge of heparin and its use in controlling unwanted clotting of the blood (thrombosis). The discovery of the nutritional importance of choline as a dietary factor that protects the liver was made by Dr. Best and his colleagues in 1932 and this subject has received continued study in Toronto. A number of papers dealing with choline and its dietary precursors (the so-called lipotropic agents) are reproduced in these pages. Other papers discuss the action of histamine, the pioneer Canadian work on collection and storage of blood serum and early experiences with the preparation of dried serum. A brief account of the contribution of Dr. Best and his colleagues to the Naval Medicine is included. Medical readers will find here a valuable condensation of all the enormous body of information on these subjects. All the references in the original papers have been re-assembled in a master bibliography which is a new and full storehouse of references. Most of the papers collected in this volume have been produced in collaboration with medical colleagues to whom Dr. Best at all times gives full and enthusiastic recognition. Indeed readers will receive a strong impression that while co-operation and collaboration in medicine are nothing new, the various teams assembled by Dr. Best at the University of Toronto have had an especially remarkable dedication and sense of excitement in the adventure of medical research.
Author: Charles Herbert Best
Publisher:
ISBN:
Category : Physiology
Languages : en
Pages : 723
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Book Description
Author: Henry B.M. Best
Publisher: Dundurn
ISBN: 155002986X
Category : Medical
Languages : en
Pages : 564
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Book Description
Although Charles Best is known for discovering insulin, the story of his life neither begins nor ends with that one moment. Not only did he make many other discoveries, he was also one half of an extraordinary couple who, during their almost sixty years together, were involved in many of the significant events of the twentieth century. Margaret & Charley is the story of these two people from their beginnings on the east coast at the turn of the century through the years that followed. Through diaries, scrapbooks, photograph albums, and other documentation, the details of their lives are shared with the reader.
Author: J.T.H. Connor
Publisher: University of Toronto Press
ISBN: 1442658029
Category : Medical
Languages : en
Pages : 406
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Book Description
A history of Toronto’s general hospital offers a window on a broader history of Upper Canada and Ontario over the last two centuries. In this lively and authoritative account, J.T.H. Connor traces the hospital’s two-hundred-year evolution, as its mandate to ‘do good’ forced constant adjustment to changing social, medical, and government attitudes. Doing Good presents the hospital’s history in three phases – roughly speaking, the first and second halves of the nineteenth century, and the twentieth century. From its conception in 1797 to the mid-1850s – it did not actually acquire a home until 1819 nor occupy it until 1829 – it functioned as a charitable institution, catering to the sick poor. It acted initially as a clearing station for sick immigrants; it later was deeply affected by political events and became embroiled in the medical turmoil of Toronto in the 1840s and early 1850s. In the second era, from the mid-1850s, it was a public charity, receiving stable government funding and constructing a new home in eastern Toronto. By the 1870s, it was winning praise as a model hospital. In the twentieth century, it early on established close links with the University of Toronto, building a vast and up-to-date new facility adjacent to the university, which opened in 1913. Its international reputation as an academic hospital grew over the decades to include a high profile in research, most notably in cancer and medical technology. By the 1960s the institution was being run as a public hospital, and the late 1990s saw its absorption into a hospital mega-corporation – the University Health Network – along with three other nearby hospitals. This work is the most comprehensive analysis of any Canadian hospital or health care institution yet to appear. Using trustees’ minutes, medical journals, newspapers, and government reports, along with correspondence, photographs, and reminiscences of trustees, nurses, doctors, and patients, Connor offers acute observation and detailed analysis, as well as compelling character studies and revealing anecdotes. Broad in scope and meticulously executed, Doing Good brings vividly to life the day-to-day routines, the behind-the-scenes intrigue, and the people and politics of a great urban hospital.
Author: Christopher S. Butler
Publisher: John Benjamins Publishing
ISBN: 902729223X
Category : Language Arts & Disciplines
Languages : en
Pages : 514
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Book Description
This book, a tribute to Angela Downing, consists of twenty papers taking a broadly functional perspective on language, with topics ranging from the general (grammar as an evolutionary product, text comprehension, integrative linguistics) to particular aspects of the grammars of languages (Bulgarian, English, Icelandic, Spanish, Swedish). The more specific papers are sequenced according to Halliday’s division into ideational, textual and interpersonal aspects of the grammar, and cover a wide range of areas, including aspect, argument structure, noun phrase/nominal group structure and nominalisations, pronominal clitics, theme in relation to writing skills, discourse structures and markers, the role of attention in conversation, the functions of topic, phatic communion, subjectification, formulaic language and modality. A recurrent theme in the volume is the use of corpus materials in order to base functional descriptions on authentic productions. Overall, the volume constitutes a panoramic but nevertheless detailed view of some important current trends in functional linguistics.
Author: Michael Bliss
Publisher: University of Toronto Press
ISBN: 1487516746
Category : Medical
Languages : en
Pages : 524
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Book Description
The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.
Author: Charles G. Roland
Publisher: Wilfrid Laurier Univ. Press
ISBN: 1554587751
Category : Medical
Languages : en
Pages : 440
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Book Description
This work is a bibliography of secondary sources in Canadian medical history.
Author: Pedro Cuatrecasas
Publisher: Springer Science & Business Media
ISBN: 3642740987
Category : Medical
Languages : en
Pages : 481
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Book Description
It is fourteen years since insulin was last reviewed in The Handbook of Ex perimental Pharmacology, in volume 32. The present endeavor is more modest in scope. Volume 32 appeared in two separate parts, each having its own subeditors, and together the two parts covered nearly all areas of insulin pharmacology. Such comprehensiveness seemed impractical in a new volume. The amount of in formation related to insulin that is now available simply would not fit in a reasonable amount of space. Furthermore, for better or worse, scientists have be come so specialized that a volume providing such broad coverage seemed likely in its totality to be of interest or value to very few individuals. We therefore decided to limit the present volume to the following areas: insulin chemistry and structure, insulin biosynthesis and secretion, insulin receptor, and insulin action at the cellular level. We felt these areas formed a coherent unit. We also felt, perhaps as much because of our own interests and perspectives as any objective reality, that these were the areas in which recent progress has been most dramatic, and yet, paradoxically and tantalizingly, these were the areas in which most has yet to be learned. Even with this limited scope, there are some major gaps in coverage. Regrettably, two important areas, the beta cell ATP-sensitive potassium channel and the glucose transporter, were among these. Nevertheless, the authors who con tributed have done an excellent job, and we would like to thank them for their diligence.
Author: Alton Meister
Publisher: John Wiley & Sons
ISBN: 0470123877
Category : Science
Languages : en
Pages : 562
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Book Description
Advances in Enzymology and Related Areas of Molecular Biology is a seminal series in the field of biochemistry, offering researchers access to authoritative reviews of the latest discoveries in all areas of enzymology and molecular biology. These landmark volumes date back to 1941, providing an unrivaled view of the historical development of enzymology. The series offers researchers the latest understanding of enzymes, their mechanisms, reactions and evolution, roles in complex biological process, and their application in both the laboratory and industry. Each volume in the series features contributions by leading pioneers and investigators in the field from around the world. All articles are carefully edited to ensure thoroughness, quality, and readability. With its wide range of topics and long historical pedigree, Advances in Enzymology and Related Areas of Molecular Biology can be used not only by students and researchers in molecular biology, biochemistry, and enzymology, but also by any scientist interested in the discovery of an enzyme, its properties, and its applications.
Author: V.C. Medvei
Publisher: CRC Press
ISBN: 9781850704270
Category : Medical
Languages : en
Pages : 582
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Book Description
The definitive reference work, this book combines detailed scientific accuracy with a classical style, erudition, and an appealing presentation. It covers the past, present, and future trends in endocrinology, and includes biographies of major figures. It provides chronological tables and name and subject indexes that make the information easily accessible.
