Salivary Gland P2 Nucleotide Receptors PDF Download
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Author: Linda Ann Neighbors Landon
Publisher:
ISBN:
Category : Adenosine triphosphate
Languages : en
Pages : 202
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Author: Linda Ann Neighbors Landon
Publisher:
ISBN:
Category : Adenosine triphosphate
Languages : en
Pages : 202
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Book Description
Author: Minjung Kang Park
Publisher:
ISBN:
Category :
Languages : en
Pages : 250
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Author: John T. Turner
Publisher: Springer Science & Business Media
ISBN: 1461218004
Category : Science
Languages : en
Pages : 439
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Book Description
A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.
Author: Ann Marie Schrader-Ratchford
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages :
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Sjögren's syndrome (SS) is an autoimmune disease that specifically targets exocrine glands, including salivary glands, and results in an impairment of secretory function. P2Y2 nucleotide receptors for extracellular ATP and UTP are up-regulated in response to stress or injury in a variety of tissues including submandibular glands (SMGs). Therefore, our objective was to assess whether P2Y2 receptor expression is up-regulated in SMGs of the NOD. B10 mouse model of SS, and to determine the function of P2Y2Rs in salivary gland tissue. Our data indicate that P2Y2Rs are up-regulated in SMGs of the NOD. B10 mice, and this up-regulation increases as the disease progresses. Moreover, data obtained using a human submandibular gland cell line, demonstrate that P2Y2Rs activate a signaling pathway leading to gene transcription via at least two distinct mechanisms. These findings suggest that regulation of P2Y2Rs is likely to be an important therapeutic target for various diseases.
Author: Farid G. El-Sayed
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages :
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Author: Mahmoud G. Khalafalla
Publisher:
ISBN:
Category :
Languages : en
Pages : 209
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Author: Jae Suk Ahn
Publisher:
ISBN:
Category :
Languages : en
Pages : 260
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Author: Margherita Sisto
Publisher: MDPI
ISBN: 3036502726
Category : Medical
Languages : en
Pages : 314
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Book Description
A large number of diseases affect salivary gland (SG) secretion through different mechanisms, leading to SG dysfunction and associated oral problems. The glands may suffer from viral, bacterial, and, albeit rarely, fungal infections, which may cause painful swelling or obstruction; they could also become the target of an autoimmune attack or may be affected by various benign and malignant tumors which consist of a heterogeneous group of lesions with complex clinical–pathological characteristics. The loss of normal SG function results in widespread deterioration of oral health. This book, entitled “Diseases of Salivary Glands”, provides an overview of recent advances in the field of SG disorders, focusing on the cellular and molecular mechanisms involved in the pathogenesis of SG diseases and on the most innovative investigation techniques that could help to preserve patients’ health, function, and quality of life.
Author: Rosa Gomez-Villafuertes
Publisher: Frontiers Media SA
ISBN: 2889639649
Category :
Languages : en
Pages : 126
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1836
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