Author: Anoop Kumar
Publisher: Humana
ISBN: 9781493924943
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
This detailed volume focuses on best practices and conditions for maintaining the most commonly used salamander species in the laboratory. Salamanders in Regeneration Research: Methods and Protocols guides readers through experimental manipulations in vivo and in vitro, respectively. With methods on targeting a wide variety of structures, ranging from the limb to the heart and to the brain, and methods for studying genetically modified organisms and tools for mining in the genomic databases. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Salamanders in Regeneration Research: Methods and Protocols provides a comprehensive collection of methods chapters.
Author:
Publisher: Academic Press
ISBN: 9780123914989
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
This new volume of Current Topics in Developmental Biology covers the area of mechanisms in regeneration. With an international board of authors, it provides a comprehensive set of reviews covering such topics as control of growth during regeneration, skeletal muscle degeneration and regeneration in mammals and flies, and suppression of regeneration in mammals.
Author: Hugh Wallace
Publisher: John Wiley & Sons
ISBN:
Category : Science
Languages : en
Pages : 296
Get Book Here
Book Description
Author: David L. Stocum
Publisher: Academic Press
ISBN: 012384861X
Category : Technology & Engineering
Languages : en
Pages : 474
Get Book Here
Book Description
Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. - Highly Commended 2013 BMA Medical Book Award for Medicine - Includes coverage of skin, hair, teeth, cornea, and central neural tissues - Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems - Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals
Author: M. Elizabeth Fini
Publisher: Springer Science & Business Media
ISBN: 3540468269
Category : Science
Languages : en
Pages : 431
Get Book Here
Book Description
"Who would believe that so small a space could contain the images of all the universe?" Leonardo da Vinci The last years of the 20th century have found the discipline of Developmental Biology returning to its original position at the forefront of biological re search. This progress can be attributed to the burgeoning knowledge base on molecules and gene families, and to the power of the molecular genetic ap proach. Topping the list of organ systems which have provided the most significant advances would have to be the eye. The vertebrate eye was one of the classic embryologic models, used to demonstrate many important prin ciples, including the concepts of inductive tissue interactions first put forth in the early 1900s. Within the last decade of this century, a return to some of the old questions with the new approaches has put eye development back into the limelight. I find this a highly appropriate topic for a book which aims to spark research for the new millennium. We begin with a chapter that discusses the anatomy of eye development, providing the basic reference information for the chapters that follow. A novel aspect of this introduction is the connection made between develop mental strategies and the eye's optical function. What also emerges from this chapter is the number of important eye structures that have barely been touched by the modern developmental biologist. Work on cornea and ante rior chamber development has lagged behind lens and retina.
Author: Jochen C. Rink
Publisher: Humana
ISBN: 9781493978007
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.
Author: Bruce M. Carlson
Publisher: Elsevier
ISBN: 0080477968
Category : Science
Languages : en
Pages : 400
Get Book Here
Book Description
With the explosion of knowledge from molecular biology and the burgeoning interest in generating or regenerating tissues or organs through various bioengineering or stem cell approaches, many scientists and students have shown a renewed interest in the phenomenon of regeneration. Because relatively few have had the luxury of being able to approach the phenomenon of regeneration from a broad biological perspective, Dr. Carlson has produced a book that outlines the fundamental principles of regeneration biology. Subject matters focus principally on regeneration in vertebrate systems, but also invertebrate regeneration. In order to manipulate regenerative processes, it is important to understand the underlying principles of regeneration. Principles of Regnerative Biology is the key introductory reference for all developmental biologists, geneticists, and tissue and stem cell researchers. - Creates a general understanding of one of the most fascinating and complex phenomena in biology - Discusses the ability and diversity of regeneration in various organisms - Explains the history and origins of cells in regenerating systems - Includes information on stem cells and its important role in regeneration
Author: Daniel Muñoz-Espin
Publisher: Springer
ISBN: 9783030449056
Category : Science
Languages : en
Pages : 222
Get Book Here
Book Description
This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.
Author: Richard J. Goss
Publisher: Elsevier
ISBN: 1483267652
Category : Science
Languages : en
Pages : 300
Get Book Here
Book Description
Principles of Regeneration focuses on the principles, methodologies, and changes involved in the process of regeneration. The book first underscores the nature of the nucleus in Acetabularia, enzyme effects, role of ribonucleic acid in morphogenesis, and functions of the stentor. The text then takes a look at the turnover in hydroids and flatworms and regeneration blastema. Discussions focus on regeneration in hydra, interstitial cells, colonial hydroids, neoblasts, and morphogenetic fields. The publication surveys segmental addition in annelids and molting, metamorphosis, and regeneration in arthropods. The termination of regeneration, importance of nerves, morphogenesis, histogenesis of the regenerate, and role of the nerves are discussed. The manuscript also examines regeneration in fishes, amphibian limb, horns and antlers, and heads and tails. The manuscript is a dependable source of data for students of developmental biology, anatomy, and evolution, as well as teachers and researchers in biology and medicine.
Author:
Publisher: Academic Press
ISBN: 012816834X
Category : Science
Languages : en
Pages : 364
Get Book Here
Book Description
Amphibian Models of Development and Disease, Volume 145 in the Current Topics in Developmental Biology series, highlights new advances in the field written by an international board of experts. New chapters in this release include Building a ciliated epithelium: Transcriptional regulation and radial intercalation of multiciliated cells, Biomechanics of Amphibian Morphogenesis, Planar cell polarity during neural tube closure, Xenopus neural crest and its relevance to human disease, Endoderm organogenesis, From egg to embryo in marsupial frogs, Evo-devo lessons from the analysis of Xenopus genomes, Transcriptional regulation during zygotic genome activation, Proteomics and metabolomics for cell lineage analysis in frog embryos, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series - Includes the latest information on Amphibian Models of Development and Disease
