Resolving The Cholesterol Controversy: The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease PDF Download
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Author: Gilbert R Thompson
Publisher: World Scientific
ISBN: 1800613997
Category : Medical
Languages : en
Pages : 247
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Book Description
Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built.The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion.The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy.
Author: Gilbert R Thompson
Publisher: World Scientific
ISBN: 1800613997
Category : Medical
Languages : en
Pages : 247
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Book Description
Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built.The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion.The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy.
Author: Gilbert R Thompson
Publisher: Wspc (Europe)
ISBN: 9781800615878
Category : Medical
Languages : en
Pages : 0
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Book Description
Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built. The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion. The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy.
Author: Alicia J. Jenkins
Publisher: Springer Nature
ISBN: 3031266811
Category : Medical
Languages : en
Pages : 925
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Book Description
Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. With an estimated 80% of people with diabetes living in disadvantaged regions, and the key roles of lipoproteins in the pathogenesis of the chronic complications of diabetes, this volume will be relevant to many readers globally. It is our intention that the contents will advance knowledge of the readers who will use it to contribute to the reduction of the burden associated with altered lipoproteins in people with diabetes. The second edition of this book provides an updated and comprehensive review of the field. The book, which includes many tables and figures, is presented in three main sections: (i) Lipoprotein metabolism, qualitative changes and measurements; (ii) Lipoproteins and the complications of diabetes; and (iii) the treatment of lipoproteins in diabetes. Each chapter from the first edition has been updated, and new topics added. New topics include the links between glycemia and lipoproteins, the role of lipoproteins in ischemic stroke, the diagnosis and management of statin intolerance (which is thought to be more common in people with diabetes) and the use of PCSK9 inhibitors and fish oils in the management of lipoproteins in people with diabetes. This book is written by an international group of experts in the clinical, laboratory and research aspects of lipoproteins in diabetes. Lipoproteins in Diabetes Mellitus, 2nd Edition is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It is a must-have resource for primary care and specialist clinicians, clinical and basic science researchers and to trainees and students.
Author: Thomas J. Moore
Publisher: Simon & Schuster
ISBN: 9780671724443
Category : Health & Fitness
Languages : en
Pages : 324
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Book Description
Covers controversies over angioplasty, cholesterol, diet, sudden cardiac death, heart bypass surgery, drugs in treatment of heart disease, etc.
Author: Aseem Malhotra
Publisher: Yellow Kite
ISBN: 1529355591
Category : Health & Fitness
Languages : en
Pages : 199
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Book Description
'Giving you all the facts to help you decide how best to have a healthy life. - Dr Phil Hammond Statins are among the most widely prescribed drugs in the world. Yet many report unacceptable side effects and a US survey revealed that 75 per cent of respondents stopped taking them within a year. So what is the evidence for their benefits? Dr Aseem Malhotra, author of the bestselling The 21-Day Immunity Plan and co-author of the bestselling The Pioppi Diet, examines the claims for statins and their role in lowering cholesterol and preventing heart disease. He introduces us to his targeted heart-health plan, which, with a diet plan, recipes and advice on reducing stress and increasing movement, can help us to live statin-free and take control of our own health. 'Backed by science, this is a riveting read for anyone with a heart.' - Liz Earle 'Aseem's programme gives you the best opportunity for a v long and healthy life.' - Ross Walker 'Get this book to figure out if a statin-free life is right for you.' - Dr Robert Lustig
Author: Donald Mark Berwick
Publisher: Oxford University Press, USA
ISBN:
Category : Language Arts & Disciplines
Languages : en
Pages : 424
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 804
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Book Description
Author: United States. General Accounting Office
Publisher:
ISBN:
Category : Consumer protection
Languages : en
Pages : 56
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Book Description
Author: Stephen T. Sinatra
Publisher: CRC Press
ISBN: 1000555801
Category : Medical
Languages : en
Pages : 426
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Book Description
Building upon its predecessor, this new edition provides an in-depth review of the role of nutrition on cardiovascular health and disease. It provides scientific and clinical insight from leaders in the field of cardiovascular medicine who explore an integrative approach to treating and curing cardiovascular diseases through conventional and non allopathic methodologies. This evidence-based book describes how to integrate nutrition, supplements, lifestyle changes, and medications for improved outcomes in several diseases and conditions including hypertension, diabetes mellitus, metabolic syndrome, and obesity.
Author:
Publisher:
ISBN:
Category : Philosophy
Languages : en
Pages : 502
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Book Description
