Regulatory Mechanisms of Striated Muscle Contraction

Regulatory Mechanisms of Striated Muscle Contraction PDF Author: Setsuro Ebashi
Publisher: Advances in Experimental Medicine and Biology
ISBN:
Category : Literary Collections
Languages : en
Pages : 432

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Book Description
This volume covers the entire spectrum of research on troponin and related muscle proteins, including pathophysiological and clinical aspects. Many color figures illustrate the three-dimensional structures of the proteins involved in the muscle functions.

Regulatory Mechanisms of Striated Muscle Contraction

Regulatory Mechanisms of Striated Muscle Contraction PDF Author: Setsuro Ebashi
Publisher: Advances in Experimental Medicine and Biology
ISBN:
Category : Literary Collections
Languages : en
Pages : 432

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Book Description
This volume covers the entire spectrum of research on troponin and related muscle proteins, including pathophysiological and clinical aspects. Many color figures illustrate the three-dimensional structures of the proteins involved in the muscle functions.

Regulatory Mechanisms of Striated Muscle Contraction

Regulatory Mechanisms of Striated Muscle Contraction PDF Author: Setsuro Ebashi
Publisher: Springer Science & Business Media
ISBN: 4431384537
Category : Medical
Languages : en
Pages : 398

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Book Description
This volume covers the entire spectrum of research on troponin and related muscle proteins, including pathophysiological and clinical aspects. It details recent advances in work on the genetic disorders of cardiac troponin and ryanodine receptor proteins. Many color figures illustrate the three-dimensional structures of the proteins involved in the muscle functions. The book will help readers understand characteristic features of the regulatory mechanisms of striated muscle contraction and their disorders at the molecular level.

Anatomy and Physiology

Anatomy and Physiology PDF Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0

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Book Description


Vascular Pharmacology: Cytoskeleton and Extracellular Matrix

Vascular Pharmacology: Cytoskeleton and Extracellular Matrix PDF Author:
Publisher: Academic Press
ISBN: 0128121521
Category : Medical
Languages : en
Pages : 406

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Book Description
Vascular Pharmacology: Cytoskeleton and Extracellular Matrix, Volume 81, contains the latest information on the vascular cytoskeleton and extracellular matrix that is presented with helpful illustrations and supporting references by prominent scientists and highly-recognized experts in the vascular field. Topics of interest in this new release include Pharmacology of the Vascular Cytoskeleton and Extracellular Matrix, The Dynamic Actin Cytoskeleton in Smooth Muscle, The Role of the Actin Cytoskeleton in the Regulation of Vascular Inflammation, The Smoothelin Family of Proteins and the Smooth Muscle Cell Contractile Apparatus, Smooth Muscle Cytoskeletal Network Regulates Expression of the Profibrotic Genes PAI-1 and CTGF, and more. - Presents a must-read book on the vascular cytoskeleton and extracellular matrix - Contains up-to-date information on the structure, function and development of the vascular cell cytoskeleton - Includes contributors from prominent scientists and highly-recognized experts with major accomplishments in the fields of the vascular cytoskeleton, extracellular matrix, mechanotransduction and vascular remodeling

The Sliding-Filament Theory of Muscle Contraction

The Sliding-Filament Theory of Muscle Contraction PDF Author: David Aitchison Smith
Publisher: Springer
ISBN: 3030035263
Category : Medical
Languages : en
Pages : 433

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Book Description
Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.

Mechanisms of Vascular Disease

Mechanisms of Vascular Disease PDF Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589

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Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Anatomy & Physiology

Anatomy & Physiology PDF Author: Lindsay Biga
Publisher:
ISBN: 9781955101158
Category :
Languages : en
Pages :

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Book Description
A version of the OpenStax text

Fundamentals of Anaesthesia

Fundamentals of Anaesthesia PDF Author: Colin Pinnock
Publisher: Cambridge University Press
ISBN: 9780521690799
Category : Medical
Languages : en
Pages : 990

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Book Description
The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.

Keynes & Aidley's Nerve and Muscle

Keynes & Aidley's Nerve and Muscle PDF Author: Christopher L.-H. Huang
Publisher: Cambridge University Press
ISBN: 1108495052
Category : Medical
Languages : en
Pages : 327

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Book Description
A complete, yet accessible and up-to-date, introduction to the cellular physiology of nerve, and skeletal, cardiac and smooth muscle.

Nerve and Muscle

Nerve and Muscle PDF Author: R. D. Keynes
Publisher: Cambridge University Press
ISBN: 9780521805841
Category : Medical
Languages : en
Pages : 196

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Book Description
Essential textbook for all undergraduate students of neurobiology, physiology, cell biology and preclinical medicine.