Regulation of the Antibody Response to Pneumococcal Capsular Polysaccharides PDF Download
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Author: Axel Jeurissen
Publisher: Leuven University Press
ISBN: 9789058674487
Category : Medical
Languages : en
Pages : 180
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Book Description
This is a Ph.D. dissertation. S. pneumoniae is a major causative agent of serious infections. Besides, the emerging resistance of S. pneumoniae to multiple antibiotic drugs is a major concern in the treatment of infections caused by this micro-organism. Therefore it is important to study the molecular mechanisms that meditate the antibody response to caps-PS. The aim of the study is to better understand the regulation and the molecular mechanisms of the immune response to pneumococcal caps-PS. The present study was undertaken to determine the role of the CD40-CD40L interaction in the murine antibody response to pneumococcal caps-PS antigens.
Author: Axel Jeurissen
Publisher: Leuven University Press
ISBN: 9789058674487
Category : Medical
Languages : en
Pages : 180
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Book Description
This is a Ph.D. dissertation. S. pneumoniae is a major causative agent of serious infections. Besides, the emerging resistance of S. pneumoniae to multiple antibiotic drugs is a major concern in the treatment of infections caused by this micro-organism. Therefore it is important to study the molecular mechanisms that meditate the antibody response to caps-PS. The aim of the study is to better understand the regulation and the molecular mechanisms of the immune response to pneumococcal caps-PS. The present study was undertaken to determine the role of the CD40-CD40L interaction in the murine antibody response to pneumococcal caps-PS antigens.
Author: Bernhard Cinader
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 424
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Book Description
Author: Roderick Heffron
Publisher: Harvard University Press
ISBN: 9780674674448
Category : Pneumonia
Languages : en
Pages : 1110
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Book Description
Author: David Salisbury
Publisher: The Stationery Office
ISBN: 9780113225286
Category : Medical
Languages : en
Pages : 486
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Book Description
This is the third edition of this publication which contains the latest information on vaccines and vaccination procedures for all the vaccine preventable infectious diseases that may occur in the UK or in travellers going outside of the UK, particularly those immunisations that comprise the routine immunisation programme for all children from birth to adolescence. It is divided into two sections: the first section covers principles, practices and procedures, including issues of consent, contraindications, storage, distribution and disposal of vaccines, surveillance and monitoring, and the Vaccine Damage Payment Scheme; the second section covers the range of different diseases and vaccines.
Author: Vincent A. Fischetti
Publisher:
ISBN:
Category : Bacterial vaccines
Languages : en
Pages : 760
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Book Description
This book is the only single volume to deal with all aspects of gram–positive pathogens. It addresses the mechanisms of gram–positive bacterial pathogenicity, including the current knowledge on gram–positive structure and mechanisms of antibiotic resistance. Emphasizing streptococci, staphylococci, listeria, and spore–forming pathogens, Gram–Positive Pathogens includes chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically in an attempt to understand the strategies used by these bacteria to cause human disease.
Author: Elaine I. Tuomanen
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 480
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Book Description
A state-of-the-art examination of research in this field and the impact of this gram-positive pathogen on human disease. * Provides coverage of topics in basic microbiology such as details of DNA transformation, molecular and medical epidemiology, the molecular basis of invasive disease, and various interactions with host defenses. * Presents important historical information on the field of pneumococcal research and suggests strategies for future investigation. * Serves as a valuable source of information for graduate and medical school students, infectious disease specialists, and field researchers in the pathogenesis of gram-positive bacteria.
Author: René Roy
Publisher: ACS Symposium
ISBN: 9780841239838
Category : Science
Languages : en
Pages : 0
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Book Description
This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.
Author: Tamas Fulop
Publisher: Springer Science & Business Media
ISBN: 1402090633
Category : Medical
Languages : en
Pages : 1693
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Book Description
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Author: WHO Expert Committee on Biological Standardization. Meeting
Publisher: World Health Organization
ISBN: 9241209771
Category : Medical
Languages : en
Pages : 241
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Book Description
This report presents the recommendations of a WHO Expert Committee commissioned to coordinate activities leading to the adoption of international recommendations for the production and control of vaccines and other biologicals and the establishment of international biological reference materials. The report starts with a discussion of general issues brought to the attention of the Committee and provides information on the status and development of reference materials for various antibodies, antigens, blood products and related substances, cytokines, growth factors, endocrinological substances and in vitro diagnostic devices. The second part of the report, of particular relevance to manufacturers and national regulatory authorities, contains revised WHO recommendations for production and control of live attenuated influenza vaccines and for production and control of pneumococcal conjugate vaccines. New WHO guidelines on the regulatory evaluation of similar biotherapeutic medicines are also provided. Also included are a list of recommendations, guidelines and other documents for biological substances used in medicine, and of international standards and reference reagent for biological substances.
Author: Keith P. Klugman
Publisher:
ISBN: 9781119738091
Category :
Languages : en
Pages :
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Book Description
