Regulation of Chromatin Plasticity in Early Embryonic Stem Cell Differentiation PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Regulation of Chromatin Plasticity in Early Embryonic Stem Cell Differentiation PDF full book. Access full book title Regulation of Chromatin Plasticity in Early Embryonic Stem Cell Differentiation by Shai Melcer. Download full books in PDF and EPUB format.
Author: Shai Melcer
Publisher:
ISBN:
Category : Chromatin
Languages : en
Pages : 87
Get Book Here
Book Description
Author: Shai Melcer
Publisher:
ISBN:
Category : Chromatin
Languages : en
Pages : 87
Get Book Here
Book Description
Author:
Publisher: Academic Press
ISBN: 0128140860
Category : Medical
Languages : en
Pages : 320
Get Book Here
Book Description
Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field. Analyzes the role of epigenetics in embryonic stem cell regulation Indicates the epigenetic mechanisms involved in stem cell differentiation and highlights modifications and misregulations that may result in disease pathogenesis Examines the potential applications of stem cell epigenetics in therapeutic disease interventions and regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast-evolving field into a clinical setting Features chapter contributions by leading international experts
Author: Warren Anthony Whyte
Publisher:
ISBN:
Category :
Languages : en
Pages : 278
Get Book Here
Book Description
Mammalian development involves the process by which a single fertilized egg develops into an adult with over 200 specialized cell types, each with a distinct gene expression pattern controlling its cellular state. As cells differentiate into specialized cell types, changes in the gene expression program occur with associated changes in chromatin. An understanding of the roles for chromatin regulators in the control of gene expression programs during differentiation is fundamental to understanding development. Although it is not yet feasible to elucidate the functions of all chromatin regulators in all vertebrate cells, recent work in embryonic stem (ES) cells has demonstrated that regulatory features of differentiation can be elucidated by focusing on the chromatin regulators involved in the changes in the pluripotent gene expression program as ES cells differentiate. New insights reveal that chromatin regulators of opposing functions share a common set of active genes in ES cells, suggesting a dynamic balance in the control of embryonic stem cell state and differentiation. I describe here the molecular mechanisms by which chromatin regulators contribute to the control of the ES cell state and differentiation, where these regulators play critical roles both in activating new gene expression programs and in silencing old programs.
Author: José Luis Sardina
Publisher: Frontiers Media SA
ISBN: 2889715108
Category : Science
Languages : en
Pages : 171
Get Book Here
Book Description
Author: Eran Meshorer
Publisher: Springer Science & Business Media
ISBN: 1441970371
Category : Science
Languages : en
Pages : 246
Get Book Here
Book Description
Stem cells have been gaining a lot of attention in recent years. Their unique potential to self-renew and differentiate has turned them into an attractive model for the study of basic biological questions such as cell division, replication, transcription, cell fate decisions, and more. With embryonic stem (ES) cells that can generate each cell type in the mammalian body and adult stem cells that are able to give rise to the cells within a given lineage, basic questions at different developmental stages can be addressed. Importantly, both adult and embryonic stem cells provide an excellent tool for cell therapy, making stem cell research ever more pertinent to regenerative medicine. As the title The Cell Biology of Stem Cells suggests, our book deals with multiple aspects of stem cell biology, ranging from their basic molecular characteristics to the in vivo stem cell trafficking of adult stem cells and the adult stem-cell niche, and ends with a visit to regeneration and cell fate reprogramming. In the first chapter, “Early embryonic cell fate decisions in the mouse”, Amy Ralson and Yojiro Yamanaka describe the mechanisms that support early developmental decisions in the mouse pre-implantation embryo and the current understanding of the source of the most immature stem cell types, which includes ES cells, trophoblast stem (TS) cells and extraembryonic endoderm stem (XEN) cells.
Author:
Publisher: Elsevier
ISBN: 0080546161
Category : Science
Languages : en
Pages : 577
Get Book Here
Book Description
This volume covers all aspects of embryonic stem cell differentiation, including mouse embryonic stem cells, mouse embryonic germ cells, monkey and human embryonic stem cells, and gene discovery. * Early commitment steps and generation of chimeric mice* Differentiation to mesoderm derivatives* Gene discovery by manipulation of mouse embryonic stem cells
Author: Jason Knott
Publisher: Springer
ISBN: 331963187X
Category : Medical
Languages : en
Pages : 85
Get Book Here
Book Description
Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.
Author: Anita Göndör
Publisher: Academic Press
ISBN: 0128034025
Category : Science
Languages : en
Pages : 498
Get Book Here
Book Description
Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes
Author: Hao Wu
Publisher:
ISBN:
Category :
Languages : en
Pages : 482
Get Book Here
Book Description
Author: Elliot R. Lee
Publisher:
ISBN:
Category :
Languages : en
Pages : 280
Get Book Here
Book Description
