Quick Guide to the Cytochrome P450 System PDF Download
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Author: Kelly L. Cozza
Publisher:
ISBN: 9781585620739
Category : Cytochrome P-450
Languages : en
Pages : 262
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Book Description
Topics covered in this volume include: an introduction to the P450 system and basic pharmacology; an introduction to P450 and to this concise guide; basic Pharmacology; metabolic variability - inhibition, induction, and pharmacogenetics; P450 Enzymes; 2D6; 3A4; 1A2; 2C9; 2C19; 2E1; guidelines; how to retrieve and review the literature.
Author: Kelly L. Cozza
Publisher:
ISBN: 9781585620739
Category : Cytochrome P-450
Languages : en
Pages : 262
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Book Description
Topics covered in this volume include: an introduction to the P450 system and basic pharmacology; an introduction to P450 and to this concise guide; basic Pharmacology; metabolic variability - inhibition, induction, and pharmacogenetics; P450 Enzymes; 2D6; 3A4; 1A2; 2C9; 2C19; 2E1; guidelines; how to retrieve and review the literature.
Author: Kelly L. Cozza
Publisher: American Psychiatric Publishing
ISBN:
Category : Medical
Languages : en
Pages : 294
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Book Description
Adverse medication reactions account for up to 7,000 deaths annually in the United States. In today's era of polypharmacy, busy clinicians - especially those who practice in medical/surgical settings - must be able to quickly find and even anticipate psychiatric drug interactions.
Author: David F.V. Lewis
Publisher: CRC Press
ISBN: 1482272776
Category : Science
Languages : en
Pages : 344
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Book Description
This book covers the relevant aspects of cytochromes P450 for understanding their structure, function and mechanisms of action, such as physicochemical characterization methods, redox interactions, evolution and genetics, experimental and theoretical models, induction, inhibition and metabolism.
Author: David F. V. Lewis
Publisher: CRC Press
ISBN: 9780748408979
Category : Medical
Languages : en
Pages : 252
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Book Description
Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry. A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. It reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.
Author: Neil B. Sandson
Publisher: American Psychiatric Publishing
ISBN:
Category : Cytochrome P-450
Languages : en
Pages : 340
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Book Description
This remarkable volume of case vignettes was written to complement the principles detailed in the comprehensive work "Concise Guide to Drug Interaction Principles for Medical Practice: Cytochrome P450s, UGTs, P-Glycoproteins," Second Edition, published by American Psychiatric Publishing, Inc. Each case is thoroughly referenced and depicts real clinical events. Many are direct narrations from patients of the author or his colleagues, with identifiers subtly altered to ensure confidentiality. Others are constructed around well-known, accepted, and multiply-verified interactions. The introductory chapter reviews core concepts and summarizes the P450 system, phase II glucuronidation and P-glycoproteins. Subsequent chapters are organized by the nature of the metabolic processes that account for the depicted drug interactions. At the end of this volume is a revealing self-assessment test case so readers can evaluate their progress in diagnosing drug interactions. Thoroughly indexed and referenced, with three indispensable appendices of tables for quick reference to the P450 system, UGTs, and P-glycoproteins, the case vignettes in this exceptional work illustrate interactions with both psychoactive agents and drugs from other branches of medicine. As such, this essential companion to more in-depth analyses of the P450 system will find an immediate audience among not only psychiatrists but also a wide range of medical specialists and generalists, as well as those who are in any way acquainted with the mental health field.
Author: Kelly L. Cozza
Publisher: American Psychiatric Publishing
ISBN:
Category : Medical
Languages : en
Pages : 564
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Book Description
An understanding of drug interactions has become essential to the practice of medicine. Since publication of the first edition of this Concise Guide in 2001, our increasing pharmacopoeia—coupled with prolonged human life spans—has made polypharmacy commonplace. Like the first edition of this unique pocket reference, the Second Edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive Web site references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, prescribing guidelines, and medicolegal issues. This exceptionally practical guide is divided into four parts: 1. An easy-to-read, succinct review of pharmacology, written with clinicians in mind, explaining the importance of understanding our metabolic system and pharmacokinetics and P-glycoprotein drug interactions. 2. Thorough, carefully referenced reviews of the most clinically relevant phase I and phase II metabolic enzymes highlighted with newly expanded tables and study cases. 3. A section unique to this book on drug interactions by medical specialty, with drug tables arranged by how they are used in specialties such as gynecology, infectious diseases, internal medicine, neurology, oncology, psychiatry, and pain medicine. 4. Chapters on practical matters: prescribing guidelines, how to identify drug interaction patterns, strategies for reviewing the current literature, and medicolegal concerns. Enhanced by detailed descriptions and clinically based explanations, and complemented by a unique pocket guide to the most common and potent inhibitors and inducers of drug metabolism, this updated concise "how-to" guide will prove indispensable for busy students, teachers, and practitioners in all medically specialties.
Author: Michael D. Coleman
Publisher: John Wiley & Sons
ISBN: 9780470689349
Category : Science
Languages : en
Pages : 360
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Book Description
Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Author: S. Cyrus Khojasteh
Publisher: Springer Nature
ISBN: 3031106911
Category : Medical
Languages : en
Pages : 241
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Book Description
This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.
Author: Pavel Anzenbacher
Publisher: John Wiley & Sons
ISBN: 352732903X
Category : Medical
Languages : en
Pages : 755
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Book Description
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Author: Catherine Pelletier
Publisher: McGraw-Hill Education / Medical
ISBN: 9780071388788
Category : Medical
Languages : en
Pages : 0
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Book Description
Organized by drug group, this book presents a complete review of pharmacology in an innovative format. Composed entirely of tables and diagrams, this book facilitates comparison and clarifies relationships among drugs in terms of interactions, pharmacokinetics, uses, and side effects. Each chapter begins with an outline of the drug class discussed, followed by a list of key terms.
