Author: Tobias Voigt
Publisher: KIT Scientific Publishing
ISBN: 3866445989
Category : Technology & Engineering
Languages : en
Pages : 168
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Book Description
This work presents three new quantitative methods for magnetic resonance imaging. A method for simultaneous mapping of B1 and T1 (MTM) is developed and validated. Electric Properties Tomography (EPT), a method for quantitative imaging of dielectric properties of tissue, is presented. Based on EPT, separate (phase-based) conductivity and (amplitude-based) permittivity measurements are introduced. Finally, a B1-based method for patient-specific local SAR measurements is presented.
Author: L. Tugan Muftuler
Publisher: Taylor & Francis
ISBN: 1439852685
Category : Medical
Languages : en
Pages : 496
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Book Description
In the medical imaging field, clinicians and researchers are increasingly moving from the qualitative assessment of printed images to the quantitative evaluation of digital images since the quantitative techniques often improve diagnostic accuracy and complement clinical assessments by providing objective criteria. Despite this growing interest, th
Author: Hanno Homann
Publisher: KIT Scientific Publishing
ISBN: 3866448007
Category : Technology & Engineering
Languages : en
Pages : 146
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Book Description
Parallel transmission enables control of the RF field in high-field Magnetic Resonance Imaging (MRI). However, the approach has also caused concerns about the specific absorption rate (SAR) in the patient body. The present work provides new concepts for SAR prediction. A novel approach for generating human body models is proposed, based on a water-fat separated MRI pre-scan. Furthermore, this work explores various approaches for SAR reduction.
Author: Schulze, Walther H. W.
Publisher: KIT Scientific Publishing
ISBN: 3731503743
Category : Technology (General)
Languages : en
Pages : 238
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Book Description
ECG imaging was performed in humans to reconstruct ventricular activation patterns and localize their excitation origins. The precision of the non-invasive reconstructions was evaluated against invasive measurements and found to be in line with the state-of-the-art literature. Statistics were produced for various excitation origins and reveal the beat-to-beat robustness of the imaging method.
Author: Baas, Tobias
Publisher: KIT Scientific Publishing
ISBN: 3866448821
Category : Technology & Engineering
Languages : en
Pages : 260
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Book Description
ECG recordings provide diagnostic relevant information on the de- and repolarisation sequences of the heart. A modification of the repolarisation sequence is assumed to cause Torsades de Pointes. Especially drug induced effects on the repolarisation processes are in focus, since some non-cardiac drugs have been associated with sudden cardiac death in the 1990s.The analysis of the ventricular repolarisation using a set of parameters depicting the morphology of the T-wave is introduced in this work. Therefore, new methods of fully automatic patient-specific QRS detection, beat classification and precise T-wave delineation are presented. Using these methods, medical studies are investigated regarding the modification of the T-wave by different compounds. Also the impact of the heart rate on the morphology of the T-wave is part of this research.The reliable identification of ventricular ectopic beats allows an analysis of the influence of these beats on subsequent heart beats. It turned out that the morphology of subsequent heart beats can significantly be changed. This might give new information on the proarrythmical risk of ventricular ectopic beats.
Author: Loewe, Axel
Publisher: KIT Scientific Publishing
ISBN: 3731505282
Category : Technology (General)
Languages : en
Pages : 342
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Book Description
Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF.
Author: Martin Wolfgang Krüger
Publisher: KIT Scientific Publishing
ISBN: 3866449488
Category : Technology & Engineering
Languages : en
Pages : 320
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Book Description
This book targets three fields of computational multi-scale cardiac modeling. First, advanced models of the cellular atrial electrophysiology and fiber orientation are introduced. Second, novel methods to create patient-specific models of the atria are described. Third, applications of personalized models in basic research and clinical practice are presented. The results mark an important step towards the patient-specific model-based atrial fibrillation diagnosis, understanding and treatment.
Author: Mathias Wilhelms
Publisher: KIT Scientific Publishing
ISBN: 3731500450
Category : Technology & Engineering
Languages : en
Pages : 206
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Book Description
Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.
Author: Keller, Matthias
Publisher: KIT Scientific Publishing
ISBN: 3731502283
Category : Technology & Engineering
Languages : en
Pages : 264
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Book Description
This work presents methods to advance electrophysiological simulations of intracardiac electrograms (IEGM). An experimental setup is introduced, which combines electrical measurements of extracellular potentials with a method for optical acquisition of the transmembrane voltage in-vitro. Thereby, intracardiac electrograms can be recorded under defined conditions. Using experimental and clinical signals, detailed simulations of IEGMs are parametrized, which can support clinical diagnosis.
Author: Pollnow, Stefan
Publisher: KIT Scientific Publishing
ISBN: 3731508869
Category : Technology (General)
Languages : en
Pages : 296
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Book Description
Catheter ablation is a major treatment for atrial tachycardias. Hereby, the precise monitoring of the lesion formation is an important success factor. This book presents computational, wet-lab, and clinical studies with the aim of evaluating the signal characteristics of the intracardiac electrograms (IEGMs) recorded around ablation lesions from different perspectives. The detailed analysis of the IEGMs can optimize the description of durable and complex lesions during the ablation procedure.
