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Author: D. Martins-de-Souza
Publisher: Karger Medical and Scientific Publishers
ISBN: 331802600X
Category : Medical
Languages : en
Pages : 152
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Book Description
This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections – Schizophrenia/Psychotic Disorders and Mood Disorders – deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.
Author: D. Martins-de-Souza
Publisher: Karger Medical and Scientific Publishers
ISBN: 331802600X
Category : Medical
Languages : en
Pages : 152
Get Book Here
Book Description
This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections – Schizophrenia/Psychotic Disorders and Mood Disorders – deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.
Author: Bernhard Baune
Publisher: Academic Press
ISBN: 0128131772
Category : Medical
Languages : en
Pages : 594
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Book Description
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
Author: Judith Pratt
Publisher: Springer
ISBN: 3319996428
Category : Medical
Languages : en
Pages : 431
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Book Description
This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.
Author: Paul C. Guest
Publisher: Springer
ISBN: 3030055426
Category : Science
Languages : en
Pages : 336
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Book Description
This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.
Author: Niruj Agrawal
Publisher: Oxford University Press
ISBN: 0192605151
Category : Medical
Languages : en
Pages : 601
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Book Description
A survey of over 900 trainees at the Royal College of Psychiatrists (RCPsych) in the United Kingdom showed that over three-quarters of psychiatry trainees desired some knowledge and training in the field of neuropsychiatry. Recent years have given rise to a substantial global focus on integrating neurosciences and neuropsychiatry in psychiatric training. Neuropsychiatry forms an important part of the psychiatric curriculum and is examined in theory and in clinical exams. Similarly, neuropsychiatry is also of interest to neurology trainees, and it is increasingly recognised that all neurology trainees should have some knowledge and experience in neuropsychiatry. Despite this growing interest, there is a dearth of neuropsychiatry textbooks specifically geared towards trainees and other clinicians who are not specialist in the field. Part of the Oxford Textbooks in Psychiatry series, the Oxford Textbook of Neuropsychiatry helps to bridge the gap between general psychiatric textbooks and reference texts in neuropsychiatry. Organised into four sections, the book covers the basic knowledge and skills relevant to neuropsychiatry, the various neuropsychiatric conditions, the principles of treatment, and perspectives for neuropsychiatry worldwide. Chapters have been written by international experts who are leaders in their own fields with the view to taking an evidence-based, up-to-date, global perspective on neuropsychiatric problems and treatment. The book is relevant to trainees in psychiatry, neurology, neurorehabilitation and also to various allied professionals in neuroscience and mental health. It covers core knowledge and skills for practice in all psychiatric disciplines including core knowledge for training in neuropsychiatry. The book meets curriculum requirements for various international training programmes and examinations, and serves as an essential training text book for all psychiatric and neurology trainees worldwide.
Author: Paul C. Guest
Publisher: Springer
ISBN: 3319524798
Category : Science
Languages : en
Pages : 362
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Book Description
Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care. The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine. It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.
Author: Elizabeth Head
Publisher: Academic Press
ISBN: 0128188464
Category : Medical
Languages : en
Pages : 354
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Book Description
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Author: Rajesh K. Kana
Publisher: Frontiers E-books
ISBN: 2889192822
Category : Autism
Languages : en
Pages : 265
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Book Description
The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives.
Author: Allan Tasman
Publisher: Springer Nature
ISBN: 3030513661
Category : Medical
Languages : en
Pages : 5499
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Book Description
Authored by over 500 internationally acclaimed expert editors and chapter authors from around the world. Completely updated and expanded with almost 40 new chapters. Significantly increased attention to the role of culture in all aspects of evaluation and care. New sections on Digital Mental Health Services and Technologies, Treatment Issues in Specific Populations and Settings, and on Prevention, Systems of Care, and Psychosocial Aspects of Treatment address key advances. This edition is the first comprehensive reference work to cover the entire field of psychiatry in an updateable format, ensuring access to state of the art information. Earlier editions were called “the best current textbook of psychiatry” by the New England Journal of Medicine, and “the gold standard” by the American Journal of Psychiatry. Tasman’s Psychiatry, 5th Edition, builds on the initial vision in prior editions of approaching psychiatric evaluation and care from an integrative bio-psycho-social-cultural perspective. It is designed to be an essential and accessible reference for readers at any level of experience. This editorial approach encompasses the importance of the first encounter between patient and clinician, followed by the complex task of beginning to develop a therapeutic relationship and to develop and implement a treatment plan in collaboration with the patient. The importance of increasing attention to the role of culture and social determinants of mental health is reflected both in specific chapters and in components of many chapters throughout the book, especially in those pertaining to clinical evaluation, the therapeutic alliance, and treatment. The global scope of this edition is reflected throughout the book, including the section on psychiatric disorders where evaluation using both ICD 11 and DSM 5-TR is discussed. Most chapters are authored by experts from at least two different countries or continents, adding a critically important dimension which often is missing in major psychiatric textbooks. Tasman’s Psychiatry, 5th Edition, is an essential reference for all medical professionals and students who need a trusted reference or learning tool for psychiatry, psychology, clinical research, social work, counseling, therapy, and all others.
Author: Paul C. Guest
Publisher: Springer Nature
ISBN: 3030550354
Category : Science
Languages : en
Pages : 274
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Book Description
Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in ‘omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from ‘omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest’s previous book Reviews on New Drug Targets in Age-Related Disorders.
