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Author: Chris Van Der Walle
Publisher: Academic Press
ISBN: 0123849365
Category : Science
Languages : en
Pages : 381
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Book Description
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
Author: Chris Van Der Walle
Publisher: Academic Press
ISBN: 0123849365
Category : Science
Languages : en
Pages : 381
Get Book Here
Book Description
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
Author: Vincent Lee
Publisher: CRC Press
ISBN: 9780824778965
Category : Science
Languages : en
Pages : 916
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Book Description
This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai
Author: Kenneth L. Andus
Publisher: Springer Science & Business Media
ISBN: 1461528984
Category : Medical
Languages : en
Pages : 507
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Book Description
In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.
Author: Vincent Lee
Publisher: CRC Press
ISBN: 9783718656417
Category : Medical
Languages : en
Pages : 400
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Book Description
First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.
Author: Randall J. Mrsny
Publisher: CRC Press
ISBN: 1420078070
Category : Medical
Languages : en
Pages : 288
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Book Description
Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is
Author: Nitai Charan Giri
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 0
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Book Description
Protein and peptide-based drugs have great potential applications as therapeutic agents since they have higher efficacy and lower toxicity than chemical drugs. However, difficulty with their delivery has limited their use. In particular, their oral bioavailability is very low, and the transdermal delivery faces absorption limitations. Therefore, most of the protein and peptide-based drugs are administered by the parenteral route. However, this route also has some problems, such as patient discomfort, especially for pediatric use. Extensive research has been performed over the past few decades to develop protein and peptide delivery systems that circumvent the problems mentioned above. Various strategies that have been employed during this time include nanoparticle carriers, absorption enhancers, enzyme inhibitors, mucoadhesive polymers, and chemical modification of protein or peptide structures. However, most of these strategies are focused on the delivery of proteins or peptides via the oral route since it is the most preferred route considering its high level of patient acceptance, long-term compliance, and simplicity. However, other routes of administration such as transdermal, nasal, pulmonary can also be attractive alternatives for protein and peptide delivery. This chapter will discuss the most effective approaches used to develop protein and peptide drug delivery systems.
Author: Kewal K. Jain
Publisher: Springer Science & Business Media
ISBN: 1588298914
Category : Science
Languages : en
Pages : 255
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Book Description
In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.
Author: Aakanchha Jain
Publisher: Elsevier
ISBN: 0443189269
Category : Science
Languages : en
Pages : 331
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Book Description
Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding. Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran. Adopts an interdisciplinary approach across biochemistry, molecular biology, pharmaceutical sciences and drug delivery, and biotechnological perspectives Features accessible figures, tables and graphical abstracts across all chapters to support understanding Examines various polysaccharides of current interest and aspects affecting their absorption, metabolism, excretion and detection
Author: Puneet Tyagi
Publisher: Academic Press
ISBN: 0128210605
Category : Business & Economics
Languages : en
Pages : 318
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Book Description
Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development
Author: Eugene J. McNally
Publisher: CRC Press
ISBN: 0849379520
Category : Medical
Languages : en
Pages : 372
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Book Description
This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytica
