Properties and Modulation of Neuronal Potassium Channels PDF Download
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Author: Hugh Malcolm Chapman
Publisher:
ISBN:
Category :
Languages : en
Pages : 316
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Book Description
Author: Hugh Malcolm Chapman
Publisher:
ISBN:
Category :
Languages : en
Pages : 316
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Book Description
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Valentin K. Gribkoff
Publisher: John Wiley & Sons
ISBN: 0470429895
Category : Science
Languages : en
Pages : 505
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Book Description
This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
Author: John Fleites
Publisher:
ISBN:
Category :
Languages : en
Pages : 41
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Book Description
Pain signaling is sensed by dorsal root ganglion (DRG) neurons. After nerve injury, DRG neurons can become hyperexcitable and generate a chronic and painful phenotype known as neuropathic pain. The exact underlying cellular mechanisms precipitating neuropathic pain are unclear, but altered ion channel properties are key in determining DRG neuronal hyperexcitability. One class of ion channels known as the sodium activated potassium (KNa) channels have been shown to regulate the resting membrane potential (RMP) and control firing accommodation in these neurons, and could very well be a central player in neuropathic pain. Multiple lines of evidence have indicated that p38 Mitogen Activated Protein Kinase (p38 MAPK) activity is important during neuropathic pain. Indeed, it has been recently shown that p38 MAPK facilitates neuronal regeneration after nerve crush of the sciatic nerve. Because of the roles of p38 MAPK in neuropathy and KNa channel involvement in DRG neuronal excitability, I sought to determine whether p38 MAPK regulates KNa channels in DRG neurons. I used anisomycin, a p38 MAPK activator, and a p38 MAPK Inhibitor to study the effects of p38 MAPK on potassium currents in rat embryonic DRG neurons and Slack KNa channels in heterologous expression systems. I show that KNa currents are upregulated by p38 MAPK in DRG neurons; Slack currents are also modulated by p38 MAPK. Using site-directed mutagenesis, I have shown that mutating one of Slack's putative p38 phosphorylation sites to glutamic acid significantly speeds up activation kinetics. These results suggest that KNa channels regulated by p38 MAPK in DRG neurons act to prevent hyperexcitability and may aid in the neuronal regeneration process after nerve injury.
Author: Arin Bhattacharjee
Publisher: Oxford University Press
ISBN: 0190669160
Category :
Languages : en
Pages : 785
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Book Description
Neurons are excitable cells. They use ions and electrical signaling to talk to each to other and when they talk to each other, neurons control behavior. The Oxford Handbook of Neuronal Ion Channels is an accessible reference describing the nature and properties of ion channels in neurons. The book explains how ion channels open and close, how they can be selective for specific ions, and how they give rise to action potentials. Included are in-depth chapters discussing specific classes of ion channels: potassium channels, sodium channels, neurotransmitter-gated ion channels and other specialized channels. Throughout the handbook, important insight is provided on the contribution ion channels make to neuronal excitability and to synaptic transmission. The handbook goes further to discuss channelopathies, a group of human diseases such as epilepsy, pain and migraines that can be caused by ion channel dysfunction. For neuroscientists, biophysicists and neuropharmacologists, this handbook is a valuable reference of ion channel biology and function.
Author: Jeffrey Noebels
Publisher: OUP USA
ISBN: 0199746540
Category : Medical
Languages : en
Pages : 1258
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Book Description
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author: Jie Zheng
Publisher: CRC Press
ISBN: 1466551429
Category : Medical
Languages : en
Pages : 682
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Book Description
The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Author: Kefan Yang
Publisher:
ISBN:
Category :
Languages : de
Pages :
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Book Description
A-type voltage-gated potassium (Kv) channels open on membrane depolarization and undergo subsequent rapid inactivation with importance in fine-tuning of cellular excitability. To serve diverse cellular needs, the inactivation is regulated by numerous mechanisms; for example, cysteine residues in the N-terminal inactivation ball domain make the inactivation susceptible to redox state changes. Hydrogen sulfide (H2S), which is enzymatically generated in various tissues, is increasingly recognized as an important signaling molecule, particularly in the cardiovascular and nervous systems. In aqueous solutions, H2S is in equilibrium with more oxidized sulfur species, e.g., polysulfides, and these sulfur-containing compounds are often collectively termed reactive sulfur species (RSS). Various roles of RSS have been identified, such as regulation of neuronal excitability, but often the mechanisms are not well understood. In this work, the H2S donor NaHS and the polysulfide donors Na2Sn were used to study whether and how A-type Kv channels might be regulated by RSS. Using the patch-clamp method, we found that Na2Sn broaden single action potentials in murine dorsal root ganglion neurons and slow the inactivation of their natively expressed A-type Kv channels (e.g., Kv1.4, Kv3.4). Therefore, we studied the functional properties of recombinant Kv1.4 and Kv3.4 and mutants thereof upon heterologous expression in HEK293T cells. Polysulfides (Na2Sn) were > 1000 times more effective than NaHS in slowing down inactivation with the potency increasing with the number of sulfur atoms (Na2S2
Author: Constance Hammond
Publisher: Elsevier
ISBN: 0323986137
Category : Psychology
Languages : en
Pages : 602
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Book Description
Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques
Author: Irwin B. Levitan
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 312
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Book Description
"Traditional neuroscience texts have stressed the output of neurons, how they turn postsynaptic targets on or off, cause muscles to twitch or convert photons into electrical pulses. Neuromodulation alters that emphasis to examine how the responses of nerve cells can be modified. Because a neuron's performance can be modulated, brains of all animals exhibit the amazing capacity to learn. Presenting the best-studied examples, Kaczmarek and Levitan provide the first detailed review of those potassium and calcium channels whose functions are modulated through receptor-mediated second messenger mechanisms and that are thought to underlie many important kinds of neuronal plasticity. This book, which covers up-to-date biophysical work in both vertebrate and invertebrate neurons, will be greatly appreciated by the readership the authors wish to reach: neurophysiological biochemists and biochemical neurophysiologists interested in understanding how behavior results from the action of nerve cells."--James H. Schwartz, M.D., Ph.D., Columbia University College of Physicians and Surgeons
