Problems with the Application of Laser Doppler Flowmetry to the Measurement of Blood Flow in the Microcirculation of the Skin PDF Download
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Author: D. P. Kernick
Publisher:
ISBN:
Category :
Languages : en
Pages : 191
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Author: D. P. Kernick
Publisher:
ISBN:
Category :
Languages : en
Pages : 191
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Author: A.P. Shepherd
Publisher: Springer Science & Business Media
ISBN: 1475720831
Category : Medical
Languages : en
Pages : 404
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The dance along the artery The circulation on the lymph Are figured in the drift of stars. T. S. Eliot Die Methode ist alles. Carl Ludwig In physiology a spirit of finesse is required. Claude Bernard Armed with modern Doppler instrumentation, scientists can now quantify the red blood cell's "dance along the artery" as well as "the drift of stars. " In disciplines of science and medicine ranging from cardiology to astronomy, the Doppler principle now provides invaluable velo city measurements in the microcosm of capillary beds and in the cosmos. The newest appiication of the ubiquitous Doppler principle, laser-Doppler velocimetry, has been used to measure blood ftow in tissue for just a few years, but we perceived that, like most new techniques, the birth of laser-Doppler blood ftowmetry was not easy, nor was it likely to pass through infancy and reach maturity without difficulty. In physiology and medicine, better techniques for measur ing blood ftow are constantly in demand, but they often exhibit an unfortun ate boom-and-bust cyde: widespread acceptance and uncritical use are soon xiii xiv Preface followed by studies delineating the limits of the method's validity. The technique is then abandoned for the next more fashionable one, thus proving Ludwig's dictum that a given method is everything or nothing depending upon whether one can believe the data it yields.
Author: A. N. Obeid
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Siv Bornmyr
Publisher:
ISBN:
Category : Laser Doppler blood flowmetry
Languages : en
Pages : 126
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 35
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Cutaneous laser-Doppler flowmetry use includes assessing thermoregulatory effector function and evaluation of clinical and pathologic conditions of the skin circulation. Skin blood flow (SkBF) on the forearm was measured simultaneously by venous occlusion plethysmography (VOP) and laser-Doppler flowmetry (LDF) during leg exercise. Fifteen subjects were studied at Ta= 300C or 350C for 30 minutes at 50 to 75% peak Vo2. LDF was measured using the Med Pacific LD6OOO, the TSl Laserflo BPM4O3A or Laserflo BPM2 with no local heating of the forearm. After the initial vasoconstriction with exercise onset, SkBF increased linearly during the exercise transient. During steady- state exercise, a non-linear relationship between LDF and VOP was observed in all experiments as SkBF measured by VOP continued to increase as SkBF measured by LDF became stable. Second order regression coefficients of LDF and VOP data were r>O.92 for 13 experiments and r>0.88 for four experiments. These data suggest that LDF may be limited by the anatomically small area for skin blood flow measurement. Alternately, VOP may detect greater arteriolar and resistance vessel vasodilation which occurred later in exercise. These observations are limited to leg exercise under conditions where skin temperature averaged 33-350C.
Author: Nithiyanantham Palanisamy
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659303692
Category : Eye
Languages : en
Pages : 176
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Cataract, Glaucoma, Age-related macular degeneration, and Diabetic retinopathy are the greatest threat to vision problems in humans. These diseases are predicted well in advance by measuring the retinal blood flow. The development of Ocular fundus reflectometry and Laser Doppler flowmetry in mid 1970's to investigate the blood flow in the posterior segment of human eye has provided much useful information on the physiology of ocular blood flow. These methods suffers some drawbacks like: (i) it does not provide absolute value of blood flow (ii) uncertainty in knowing the sampling volume (iii) optical properties of ocular tissue (iv) angle of impinging and scattering beams (v) changes in pupil diameter. This book provides the experimental results of effect of one drop of timolol on heart rate, IOP and choroidal blood flow (ChBF). In the book, we proposed use of an artificial pupil to measure the effect of various pharmacological agents on choroidal blood flow (ChBF) using LDF reduces the variability and increases the sensitivity of the technique to detect the changes in ChBF
Author: John E. Tooke
Publisher: Springer Science & Business Media
ISBN: 1461323355
Category : Medical
Languages : en
Pages : 224
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Book Description
In 1628 William Harvey published his discovery of the existence of the microcirculation which he deduced from careful anatomical and physiological study. Thirty-three years later, Malpighi confirmed the presence of capillaries through direct microscopical observation. Subsequent scientific advance has been slow, and in view of the fact that microvascular in the genesis and expression of many pathophysiology may be implicated diseases, our know ledge of human microvascular function is surprisingly limited. This ignorance attests to the difficulty of studying something that is both minute and inaccessible without disturbing the quantity that is being measured. In the last fifteen years, however, direct techniques have been developed for studying human microvascular pressure, flow and permeability. These methods have provided new insights into human microvascular function in health and disease. At the same time there has been a steady growth of new indirect techniques based on a w ide range of physical principles that reflect some or other aspect of microvascular function.
Author: Laura Sironi
Publisher:
ISBN: 9781510605008
Category : Blood flow
Languages : en
Pages : 94
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Book Description
This Spotlight reviews non-invasive optical methods to determine the blood flow velocity in microcirculation, with an emphasis on the most recent developments that may be routinely applied in cellular biology laboratories. The methods covered in this book include both scanning and whole-field optical imaging techniques based on endogenous or exogenous (fluorescent) contrast agents for plasma and red-blood-cell visualization, such as laser Doppler velocimetry, laser speckle contrast imaging, diffuse correlation spectroscopy, particle image velocimetry, and two-photon microscopy. Several methods have been developed to quantify the blood flow velocity within microvessels by exploiting the cross-correlation concept applied to optical scanning microscopes: dual-foci cross-correlation, spatio-temporal image correlation spectroscopy, line-scanning techniques, and a recently developed single raster-scanned xy-image technique (FLICS). The basic operational principles, the advantages and disadvantages, and the technical issues of these methods will be discussed and compared, and their applications in biomedical research will be presented.
Author: Abdul Hamid El-Sawy
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author:
Publisher:
ISBN:
Category : Disabled veterans
Languages : en
Pages : 752
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