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Author: Scott Dessain
Publisher: Academic Press
ISBN: 0128092092
Category : Medical
Languages : en
Pages : 276
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Book Description
Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This "Valley of Death" squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of "conventional wisdom" that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. Explains why translation of biotech discovery into medicine succeeds so infrequently that it’s been dubbed the Valley of Death Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better
Author: Scott Dessain
Publisher: Academic Press
ISBN: 0128092092
Category : Medical
Languages : en
Pages : 276
Get Book
Book Description
Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This "Valley of Death" squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of "conventional wisdom" that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. Explains why translation of biotech discovery into medicine succeeds so infrequently that it’s been dubbed the Valley of Death Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better
Author: Al Checchi
Publisher: Open Road Media
ISBN: 1453221018
Category : Business & Economics
Languages : en
Pages : 324
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Book Description
Entertaining, fast-paced, instructional, The Change Maker is not only a memoir, but a blueprint for how we can change our own lives, as well as the world around us, by providing personal lessons in the values of strategic thinking and responsible leadership. Through compelling true stories, both humorous and serious, Al Checchi demonstrates that through experience, vision, and courage, one person can make a difference and lead others to move beyond their comfort zones and transform our institutions. Al Checchi, a remarkable change maker, chronicles how his creativity, strategic thinking, and negotiating skills helped transform three major American institutions—Marriott Corporation, Walt Disney, and Northwest Airlines—and led him to challenge the California political establishment as a candidate for governor. Peppered with excerpts from speeches and articles, The Change Maker offers thoughtful perspective on institutional change in America since the 1960s, and scalding commentary on the current state of our public and private institutions, political parties, the emergent political class, and the economic policies and leadership of today’s administration. The Change Maker challenges us to confront the status quo and demand accountability and a restoration of the fiduciary standards that are so vital to reclaiming and maintaining America's position of economic and political leadership. Readers will finish the book feeling revitalized, hopeful, and armed with new ideas on how change can, and always will, occur.
Author: United States. Congress. Senate. Special Committee on Aging
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 64
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Book Description
Author: The Gardeners and Farmers of Centre Terre Vivante
Publisher: Chelsea Green Publishing
ISBN: 1933392592
Category : Cooking
Languages : en
Pages : 226
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Book Description
Translation of: Conserves naturelles des quatre saisons.
Author: James M Lindgren
Publisher: NYU Press
ISBN: 1479853941
Category : History
Languages : en
Pages : 521
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Book Description
Preserving South Street Seaport tells the fascinating story, from the 1960s to the present, of the South Street Seaport District of Lower Manhattan. Home to the original Fulton Fish Market and then the South Street Seaport Museum, it is one of the last neighborhoods of late 18th- and early 19th-century New York City not to be destroyed by urban development. In 1988, South Street Seaport became the city's #1 destination for visitors. Featuring over 40 archival and contemporary black-and-white photographs, this is the first history of a remarkable historic district and maritime museum. Lindgren skillfully tells the complex story of this unique cobblestoned neighborhood. Comprised of deteriorating, 4-5 story buildings in what was known as the Fulton Fish Market, the neighborhood was earmarked for the erection of the World Trade Center until New Jersey forced its placement one mile westward. After Penn Station’s demolition had angered many New York citizens, preservationists mobilized in 1966 to save this last piece of Manhattan’s old port and recreate its fabled 19th-century “Street of Ships.” The South Street Seaport and the World Trade Center became the yin and yang of Lower Manhattan’s rebirth. In an unprecedented move, City Hall designated the museum as developer of the twelve-block urban renewal district. However, the Seaport Museum,whose membership became the largest of any history museum in the city, was never adequately funded, and it suffered with the real estate collapse of 1972. The city, bankers, and state bought the museum’s fifty buildings and leased them back at terms that crippled the museum financially. That led to the controversial construction of the Rouse Company's New Fulton Market (1983) and Pier 17 mall (1985). Lindgren chronicles these years of struggle, as the defenders of the people-oriented museum and historic district tried to save the original streets and buildings and the largest fleet of historic ships in the country from the schemes of developers, bankers, politicians, and even museum administrators. Though the Seaport Museum’s finances were always tenuous, the neighborhood and the museum were improving until the tragedy of 9/11. But the prolonged recovery brought on dysfunctional museum managers and indifference, if not hostility, from City Hall. Superstorm Sandy then dealt a crushing blow. Today, the future of this pioneering museum, designated by Congress as America’s National Maritime Museum, is in doubt, as its waterfront district is eyed by powerful commercial developers. While Preserving South Street Seaport reveals the pitfalls of privatizing urban renewal, developing museum-corporate partnerships, and introducing a professional regimen over a people’s movement, it also tells the story of how a seedy, decrepit piece of waterfront became a wonderful venue for all New Yorkers and visitors from around the world to enjoy. This book will appeal to a wide audience of readers in the history and practice of museums, historic preservation, urban history and urban development, and contemporary New York City. This book is supported by a grant from Furthermore: a program of the J.M. Kaplan Fund.
Author: Ken Abraham
Publisher: Doubleday Books
ISBN: 9780385486996
Category : Religion
Languages : en
Pages : 244
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Book Description
Weekend Promise Keeper gatherings are spiritual pep rallies for men seeking meaning in their lives. Whether black, white, Hispanic, or Asian, all are encouraged to dedicate themselves to Jesus Christ, to nurture their relationships with God, and to straighten out their lives. This sympathetic look at the Promise Keepers takes a glimpse into this dynamic group. Illustrated with 16 black-and-white photos.
Author: Rena Kornreich Gelissen
Publisher: Beacon Press
ISBN: 0807093130
Category : Biography & Autobiography
Languages : en
Pages : 289
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Book Description
An expanded edition of the powerful memoir about two sisters' determination to survive during the Holocaust featuring new and never before revealed information about the first transport of women to Auschwitz In March 1942, Rena Kornreich and 997 other young women were rounded up and forced onto the first Jewish transport of women to Auschwitz. Soon after, Rena was reunited with her sister Danka at the camp, beginning a story of love and courage that would last three years and forty-one days. From smuggling bread for their friends to narrowly escaping the ever-present threats that loomed at every turn, the compelling events in Rena’s Promise remind us that humanity and hope can survive inordinate brutality.
Author: Douglas W. Portmore
Publisher: Oxford University Press
ISBN: 0190905336
Category : Philosophy
Languages : en
Pages : 656
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Book Description
Consequentialism is a major moral theory in contemporary philosophy: it is the view that the only thing that matters when making moral decisions is the outcome of those decisions. Consequentialists hold that to morally assess an act, we must first evaluate and rank the various ways that things could turn out depending on whether it or some alternative act is performed. Whether we should perform that act thus depends on how its outcome ranks relative to those of its alternatives. Consequentialism rivals deontology, contractualism, and virtue ethics, but, more importantly, it has influenced contemporary moral philosophy such that the consequentialist/non-consequentialist distinction is one of the most central in normative ethics. After all, every plausible moral theory must concede that the goodness of an act's consequences is something that matters, even if it's not the only thing that matters. Thus, all plausible moral theories will accept that both 1) an act's producing good consequences constitutes a moral reason to perform it, and 2) the better its consequences, the more of a moral reason there is to perform it. In this way, much of consequentialist ethical theory is important for normative ethics in general. This Oxford Handbook contains thirty-two previously unpublished contributions by top moral philosophers examining the current state of play in consequentialism and pointing to new directions for future research. The volume is organized into four major sections: foundational issues; objections to consequentialism; its forms and limits; and consequentialism's implications for policy, practice, and social reform.
Author: Vannetta Chapman
Publisher: Harvest House Publishers
ISBN: 0736946136
Category : Fiction
Languages : en
Pages : 308
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Book Description
A Promise for Miriam, the first book in a brand-new romantic series from popular author Vannetta Chapman, introduces the Amish community of Pebble Creek and some of the kind, caring people there. As they face challenges to their community from the English world, they come together to reach out to their non-Amish neighbors while still preserving their cherished Plain ways. Amish schoolteacher Miriam King loves her students. At 26, most women her age are married with children of their own, but she hasn’t yet met anyone who can convince her to give up the Plain school that sits along the banks of Pebble Creek. Then newcomer Gabriel Miller steps into her life, bringing his daughter, an air of mystery, and challenges Miriam has never faced before. Will Gabe be able to let go of the past that haunts him? He thinks he just wants to be left alone, but the loving and warm community he and his daughter have moved to has other plans for him. After a near tragedy is averted, he hesitantly returns offers of help and friendship, and he discovers he can make a difference to the people of Pebble Creek—and maybe find love again.
Author: Kevin West
Publisher: Knopf
ISBN: 0307599485
Category : Cooking
Languages : en
Pages : 546
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Book Description
The ultimate canning guide for cooks—from the novice to the professional—and the only book you need to save (and savor) the season throughout the entire year "Gardening history, 18th-century American painters, poems, and practical information; it's a rich book. And unlike other books on preserving, West gives recipes that will goad you to make easy preserves.” —The Atlantic Strawberry jam. Pickled beets. Homegrown tomatoes. These are the tastes of Kevin West’s Southern childhood, and they are the tastes that inspired him to “save the season,” as he traveled from the citrus groves of Southern California to the cranberry bogs of Massachusetts and everywhere in between, chronicling America’s rich preserving traditions. Here, West presents his findings: 220 recipes for sweet and savory jams, pickles, cordials, cocktails, candies, and more—from Classic Apricot Jam to Green Tomato Chutney; from Pickled Asparagus with Tarragon and Green Garlic to Scotch Marmalade. Includes 300 full-color photographs.
