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Author:
Publisher: Springer
ISBN: 9783642737985
Category : Medical
Languages : en
Pages : 510
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Book Description
The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Author:
Publisher: Springer
ISBN: 9783642737985
Category : Medical
Languages : en
Pages : 510
Get Book Here
Book Description
The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Author:
Publisher: Springer Science & Business Media
ISBN: 3642737978
Category : Medical
Languages : en
Pages : 527
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Book Description
The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Author: Sharon Flake
Publisher: Little, Brown Books for Young Readers
ISBN: 1423132513
Category : Juvenile Fiction
Languages : en
Pages : 176
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Book Description
Maleeka suffers every day from the taunts of the other kids in her class. If they're not getting at her about her homemade clothes or her good grades, it's about her dark, black skin. When a new teacher, whose face is blotched with a startling white patch, starts at their school, Maleeka can see there is bound to be trouble for her too. But the new teacher's attitude surprises Maleeka. Miss Saunders loves the skin she's in. Can Maleeka learn to do the same?
Author: Thierry Jonquet
Publisher: Profile Books
ISBN: 1847655963
Category : Fiction
Languages : en
Pages : 128
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Book Description
Richard Lafargue is an eminent plastic surgeon haunted by dirty secrets. He has an operating theatre in the basement of his chateau and keeps his partner Eve imprisoned in her bedroom, a room he has equipped with an intercom and 300-watt speakers through which he bellows orders. Eve is only allowed out to be paraded at cocktail parties and on the last Sunday of each month, when the couple visit a young woman in a mental asylum. Following these outings, Lafargue humiliates Eve by forcing her to perform lewd sexual acts with strangers while he watches through a one-way mirror. In alternating chapters, Jonquet introduces seemingly unrelated characters - a criminal on the run after murdering a policeman, and an abducted young man who finds himself chained naked in a dark chamber, forced to endure all manner of physical torture at the hands of a mysterious stranger, whom he calls Mygale, after a type of tropical spider. All of these characters are caught in a deceitful web, waiting to meet their fate.
Author: Sharon G. Flake
Publisher: Scholastic Inc.
ISBN: 1338573195
Category : Young Adult Fiction
Languages : en
Pages : 289
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Book Description
The powerful and long-anticipated companion to The Skin I'm In, Sharon Flake's bestselling modern classic, presents the unflinching story of Char, a young woman trapped in the underworld of human trafficking. My feet are heavy as stones when I walk up the block wondering why I can't find my old self.In The Skin I'm In, readers saw into the life of Maleeka Madison, a teen who suffered from the ridicule she received because of her dark skin color. For decades fans have wanted to know the fate of the bully who made Maleeka's life miserable, Char.Now in Sharon Flake's latest and unflinching novel, The Life I'm In, we follow Charlese Jones, who, with her raw, blistering voice speaks the truths many girls face, offering insight to some of the causes and conditions that make a bully. Turned out of the only home she has known, Char boards a bus to nowhere where she is lured into the dangerous web of human trafficking. Much is revealed behind the complex system of men who take advantage of vulnerable teens in the underbelly of society. While Char might be frightened, she remains strong and determined to bring herself and her fellow victims out of the dark and back into the light, reminding us why compassion is a powerful cure to the ills of the world.Sharon Flake's bestselling, Coretta Scott King Award-winning novel The Skin I'm In was a game changer when it was first published more than twenty years ago. It redefined young adult literature by presenting characters, voices, and real-world experiences that had not been fully seen. Now Flake offers readers another timely and radical story of a girl on the brink and how her choices will lead her to either fall, or fly.
Author: Nancy A. Monteiro-Riviere
Publisher: CRC Press
ISBN: 1420079182
Category : Medical
Languages : en
Pages : 452
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Book Description
This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr
Author: Natalie K. Carricarte
Publisher:
ISBN: 9780615362380
Category :
Languages : en
Pages : 43
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Book Description
Author: T. Agner
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318055867
Category : Medical
Languages : en
Pages : 172
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Book Description
Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.
Author: Kevin Patrick Siena
Publisher: Routledge
ISBN: 1317319540
Category : History
Languages : en
Pages : 294
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Book Description
Diseases affecting the skin have tended to provoke a response of particular horror in society. This collection of essays uses case studies to chart the medical history of skin from the eighteenth to the twentieth century.
Author: Desmond Cole
Publisher: Doubleday Canada
ISBN: 038568634X
Category : Political Science
Languages : en
Pages : 258
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Book Description
NATIONAL BESTSELLER WINNER OF THE 2020 TORONTO BOOK AWARD A bracing, provocative, and perspective-shifting book from one of Canada's most celebrated and uncompromising writers, Desmond Cole. The Skin We're In will spark a national conversation, influence policy, and inspire activists. In his 2015 cover story for Toronto Life magazine, Desmond Cole exposed the racist actions of the Toronto police force, detailing the dozens of times he had been stopped and interrogated under the controversial practice of carding. The story quickly came to national prominence, shaking the country to its core and catapulting its author into the public sphere. Cole used his newfound profile to draw insistent, unyielding attention to the injustices faced by Black Canadians on a daily basis. Both Cole’s activism and journalism find vibrant expression in his first book, The Skin We’re In. Puncturing the bubble of Canadian smugness and naive assumptions of a post-racial nation, Cole chronicles just one year—2017—in the struggle against racism in this country. It was a year that saw calls for tighter borders when Black refugees braved frigid temperatures to cross into Manitoba from the States, Indigenous land and water protectors resisting the celebration of Canada’s 150th birthday, police across the country rallying around an officer accused of murder, and more. The year also witnessed the profound personal and professional ramifications of Desmond Cole’s unwavering determination to combat injustice. In April, Cole disrupted a Toronto police board meeting by calling for the destruction of all data collected through carding. Following the protest, Cole, a columnist with the Toronto Star, was summoned to a meeting with the paper’s opinions editor and informed that his activism violated company policy. Rather than limit his efforts defending Black lives, Cole chose to sever his relationship with the publication. Then in July, at another police board meeting, Cole challenged the board to respond to accusations of a police cover-up in the brutal beating of Dafonte Miller by an off-duty police officer and his brother. When Cole refused to leave the meeting until the question was publicly addressed, he was arrested. The image of Cole walking out of the meeting, handcuffed and flanked by officers, fortified the distrust between the city’s Black community and its police force. Month-by-month, Cole creates a comprehensive picture of entrenched, systemic inequality. Urgent, controversial, and unsparingly honest, The Skin We’re In is destined to become a vital text for anti-racist and social justice movements in Canada, as well as a potent antidote to the all-too-present complacency of many white Canadians.
