Palladium-catalyzed Intermolecular Coupling of 2-haloallylic Acetates with Simple Phenols, and Sequential Formation of Benzofuran Derivatives Through the Intramolecular Cyclization PDF Download
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Author: Seble-Hiwot Teshome Wagaw
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Languages : en
Pages : 280
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Author: Qinhua Huang
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Category :
Languages : en
Pages : 0
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The tert-butylimines of o-(1-alkynyl)benzaldehydes and analogous pyridinecarbaldehydes have been cyclized under very mild reaction conditions in the presence of I2, ICl, PhSeCl, and p-O2NC6H4SCl to give the corresponding halogen-, selenium-, and sulfur containing disubstituted isoquinolines and naphthyridines, respectively. Monosubstituted isoquinolines and naphthyridines have been synthesized by the metal-catalyzed ring closure of these same iminoalkynes. The Pd(II)-catalyzed cyclization of 2-(1-alkynyl)arylaldimines in the presence of various alkenes provides an efficient way to synthesize a variety of 4-(1-alkenyl)-3-arylisoquinolines in moderate to excellent yields. The introduction of an ortho-methoxy group on the arylaldimine promotes the Pd-catalyzed cyclization and stabilizes the resulting Pd(II) intermediate, improving the yields of the isoquinoline products. Highly substituted naphthalenes have been synthesized by the palladium-catalyzed annulation of a variety of internal alkynes, in which two new carbon-carbon bonds are formed in a single step under relatively mild reaction conditions. This method has also been used to synthesize carbazoles, although a higher reaction temperature is necessary. This method accommodates a variety of functional groups and affords the anticipated highly substituted naphthalenes and carbazoles in good to excellent yields. Novel palladium migration/arylation methodology for the synthesis of complex fused polycycles has been developed, in which one or more sequential Pd-catalyzed intramolecular migration processes involving C-H activation are employed. The chemistry works best with electron-rich aromatics, which is in agreement with the idea that these palladium-catalyzed C-H activation reactions parallel electrophilic aromatic substitution. A relatively efficient synthesis of cyclopropanes has been developed using palladium-catalyzed C-H activation chemistry, in which two new carbon-carbon bonds are formed in a single step. This method involves the palladium-catalyzed activation of relatively unreactive C-H bonds, and provides a very efficient way to synthesize cyclopropapyrrolo[1,2-a]indoles, analogues of the mitomycin antibiotics.
Author: Jiro Tsuji
Publisher: Springer Science & Business Media
ISBN: 3642674755
Category : Science
Languages : en
Pages : 221
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Around 30 years ago the transition metal chemistry received great impulses. In the focus have been reactions of nickel and cobalt and herein especially their carbonyls. Also industrial processes have been developed. When the technical oxidation of ethylene with palladium chloride had been discovered, and a great number oflaboratory reactions, many groups have turned towards this subject. Apart from two important industrial processes - acetaldehyde and vinylacetate from ethylene - a great number of conversions and catalytic reactions with palladium compounds have been researched. Their mechanisms have been cleared up and have con tributed to a better understanding of the complex chemistry of palladium. Last but not least these reactions have also served for more understanding of organic transition metal compounds and catalyses in general. Numerous conventional reactions appear today in a different light. The effects of co-
Author: Xiao-Feng Wu
Publisher: John Wiley & Sons
ISBN: 3527338888
Category : Technology & Engineering
Languages : en
Pages : 596
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Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.
Author: Huanfeng Jiang
Publisher: Springer
ISBN: 9783662489994
Category : Science
Languages : en
Pages : 0
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This book presents efficient and practical methods for the synthesis of various functionalized organic molecules from haloalkynes through different reaction processes such as cross-coupling reactions, nucleophilic additions and cycloadditions. It consists of four chapters demonstrating interesting examples of these transformations, and showcasing the synthetic power of haloalkynes for rapid assembly of complex molecular structures. Most of the protocols allow multiple bond-forming events to occur in a single operation, offering opportunities to advance chemical synthesis and address the increasing demands for green and sustainable chemistry. It also presents a wide range of functionalized products, including many synthetically useful conjugated cyclic and acyclic structures that have potential applications in materials science, chemical biology and natural product synthesis. This book is a valuable reference not only for organic chemists, but also for biologists and materials scientists involved in the modern synthesis of organic compounds and materials. Huanfeng Jiang and Wanqing Wu are both Professors at the School of Chemistry and Chemical Engineering, South China University of Technology, China. Chuanle Zhu is a Postdoctoral Fellow at the School of Chemistry and Chemical Engineering, South China University of Technology, China.
Author: Javier García-Martínez
Publisher: John Wiley & Sons
ISBN: 3527336052
Category : Technology & Engineering
Languages : en
Pages : 794
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Winner of the CHOICE Outstanding Academic Title 2017 Award This comprehensive collection of top-level contributions provides a thorough review of the vibrant field of chemistry education. Highly-experienced chemistry professors and education experts cover the latest developments in chemistry learning and teaching, as well as the pivotal role of chemistry for shaping a more sustainable future. Adopting a practice-oriented approach, the current challenges and opportunities posed by chemistry education are critically discussed, highlighting the pitfalls that can occur in teaching chemistry and how to circumvent them. The main topics discussed include best practices, project-based education, blended learning and the role of technology, including e-learning, and science visualization. Hands-on recommendations on how to optimally implement innovative strategies of teaching chemistry at university and high-school levels make this book an essential resource for anybody interested in either teaching or learning chemistry more effectively, from experience chemistry professors to secondary school teachers, from educators with no formal training in didactics to frustrated chemistry students.
Author: Javier García-Martínez
Publisher: John Wiley & Sons
ISBN: 3527635653
Category : Science
Languages : en
Pages : 311
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Book Description
In the International Year of Chemistry, prominent scientists highlight the major advances in the fight against the largest problems faced by humanity from the point of view of chemistry, showing how their science is essential to ensuring our long-term survival. Following the UN Millennium Development Goals, the authors examine the ten most critical areas, including energy, climate, food, water and health. All of them are opinion leaders in their fields, or high-ranking decision makers in national and international institutions. Intended to provide an intellectual basis for the future development of chemistry, this book is aimed at a wide readership including students, professionals, engineers, scientists, environmentalists and anyone interested in a more sustainable future.
Author: Matthias Beller
Publisher: Springer Science & Business Media
ISBN: 354033002X
Category : Science
Languages : en
Pages : 289
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Book Description
Carbonylation reactions are of major importance in both organic and industrial chemistry. Due to the availability, price and reactivity pattern, carbon monoxide is becoming a more and more important building block for fine and bulk chemicals. The major reaction types of carbon monoxide are comprehensively discussed by leading experts from academia and industry. The authors highlight important carbonylation reactions such as hydroformylation, alkoxy-carbonylations, co/olefin-copolymerization, Pauson-Khand reactions and others. They illustrate applications in organic synthesis and give industrial examples. This volume is designed to provide graduate students and researchers with essential information on the use of carbon monoxide in organic synthesis. Therefore, the reader will get a balanced view of this developing and complex subject.
Author: Sergeĭ Dmitrievich Varfolomeev
Publisher: Nova Publishers
ISBN: 9781600214257
Category : Science
Languages : en
Pages : 148
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Book Description
This book presents recent research in Chemical and Biochemical physics. Chemical physics addresses a large range of problems. An effective chemical physicist is a jack-of-all-trades, able to apply the principles and techniques of the field to everything from high-tech materials to biology. Just as the fields of chemistry and physics have expanded, so have chemical physics subject areas, which include polymers, materials, surfaces/interfaces, and biological macromolecules, along with the traditional small molecule and condensed phase systems. Biochemical Physics is a science that joins the three natural sciences biology, chemistry and physics into one comprehensive study. N.M. Emanuel pioneered this science over fifty years ago. This book presents papers, written by Emanuel's students, that reveal recent developments in this interesting field.
