Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470514914
Category : Nature
Languages : en
Pages : 346
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Book Description
Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
Author: John T. Turner
Publisher: Springer Science & Business Media
ISBN: 1461218004
Category : Science
Languages : en
Pages : 439
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Book Description
A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.
Author: Robert M. Berne
Publisher: Springer Science & Business Media
ISBN: 146133909X
Category : Medical
Languages : en
Pages : 557
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Book Description
The principal objective of this symposium was to bring together investigators from all over the world who work in diverse areas of research but share a common interest in the physiologic and pathophysiologic funetions of the nueleoside adenosine. In 1978, the "International Conference on Physiological and Regulatory Funetions of Adenosine and Adenine Nueleotides," held in Banff, Canada, served as an effective catalyst in enabling scientists with differ ent points of view to exchange information and ideas on this subject. Since 1978, the amount of research on different as peets of adenosine metabolism, mechanism of action, transport, and function in various tissues (in both nor maI and abnormal states) has increased exponentially, and there was an urgent need for another meeting for updating information on this burgeoning subject. The focus of the meeting was extremely sharp, but the scope of the subject material was very broad. Scientists categorized as chemists, biochemists, physiologists, pharmacologists, and immunologists, working with cells and eelI fragments, with tissues such as heart, brain, musele, fat, kidney, and with human beings having immune deficiency diseases participated in the sym posium. They had an opportunity to air their differences, reinforce their areas of agreement, and, most important, they educated each other with respeet to research on adenosine; it is hoped that they also enriched their own research programs from the information they gained from their fellow participants.
Author: Robson Faria
Publisher: BoD – Books on Demand
ISBN: 1789845343
Category : Medical
Languages : en
Pages : 112
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Book Description
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Author: Kenneth J Broadley
Publisher: CRC Press
ISBN: 1135741395
Category : Medical
Languages : en
Pages : 612
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Book Description
This overview of autonomic pharmacology describes the anatomy, physiology and pharmacology of the autonomic involuntary nervous system. Covering the diverse group of drugs acting on the autonomous nervous system, their actions are reviewed together with their clinical uses, side effects, interactions and subcellular mechanisms of action. Information is organized in a logical flow, bringing together the latest advances in an integrated form on topics usually found only in a fragmented form.; This work is intended for all those researching in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry and molecular biology.
Author: Liselotte Plesner
Publisher: Springer Science & Business Media
ISBN: 1461559553
Category : Science
Languages : en
Pages : 286
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Book Description
Proceedings of the First International Workshop held in Mar de Plata, Argentina, August 26-30, 1996
Author: Luiz Belardinelli
Publisher: Springer Science & Business Media
ISBN: 1461520118
Category : Medical
Languages : en
Pages : 515
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Book Description
This book contains a selection of lectures given during the 5th International Symposium on Adenosine and Adenine Nucleotides, recently held in Philadelphia, Pennsylvania. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology covers a wide range of subjects from molecular and cellular biology to clinical applications. A great emphasis has been placed on cutting edge information derived from studies using molecular and cellular biology techniques applied to the field of adenosine and adenine nucleotide research. The book also includes information on potentially promising developments in the therapeutic applications of adenosine related drugs and ATP. The tradition of past meetings is also maintained by including in the program presentations of new research in the areas of purine metabolism and physiology, and pharmacology of adenosine and adenine nucleotides. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology is an excellent, up-to-date reference book for basic and clinical scientists in the field of adenosine and adenine nucleotides.
Author: I.K. Morton
Publisher: Springer Science & Business Media
ISBN: 9401144397
Category : Medical
Languages : en
Pages : 347
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Book Description
The purpose of this dictionary is to provide a convenient and affordable personal desk reference resource. The authors, who have many years experience in pharmacological research, teaching and editing, recognized a need for a single up-to-date volume encompassing material that hitherto could be gathered only from a well-stocked library. This book comprises two main sections: an A-Z listing of drugs and their properties; and a descriptive glossary of technical terms. The level and scope of this reference material will make it essential for pharmacologists and medicinal chemists, from the graduate student to established worker. It should also be valuable to workers in allied biomedical diSCiplines, such as biochemistry and physiology, medical students and science writers and editors. Scope The dictionary is centred on pharmacologically active agents. Workers in drug-related diSCiplines need to correctly identify individual agents from an arsenal of pharmacologically active compounds, each with a number of alternative drug names according to the country or naming convention.
Author: Geoffrey Burnstock
Publisher: Springer Science & Business Media
ISBN: 3642288634
Category : Medical
Languages : en
Pages : 724
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Book Description
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1460
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Book Description
