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Author: Toshikazu Yoshikawa
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805572301
Category : Medical
Languages : en
Pages : 191
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Book Description
In the 1980s, biochemists and biologists were attracted by the role of reactive oxygen species in the irreversible damage or modification of the structure of biological molecules. However, in the 1990s, reactive oxygen species have been recognized to be involved in reversible structural alterations of molecules: The homeostatic modulation of oxidant levels is a highly efficient mechanism that allows all cells to tightly control their redox status within a very narrow range. Especially the activity of the Rel/NF-kB family of transcriptional factors that regulate responses in inflammation, reperfusion injury and apoptosis is controlled by intracellular reactive oxygen species levels. Our understanding of how these transcriptional factors are negatively or positively regulated by oxidative stress has since greatly increased. Questions for future investigation center on the modulation of oxidative stress by personal genome information for the prevention of several pathologic states.
Author: T. Yoshikawa
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318007064
Category : Medical
Languages : en
Pages : 191
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Book Description
Over the past several years, there has been an extraordinarily rapid growth in our knowledge of oxidative stress and its possible involvement in both normal essential biology and digestive diseases. Oxidative stress is defined as a disturbance in the prooxidant-antioxidant balance in favor of the former, and has been suggested as a causative factor in inflammation, ischemia and carcinogenesis in the digestive organs. In the 1980s, biochemists and biologists were attracted by the role of reactive oxygen species in the irreversible damage or modification of the structure of biological molecules. However, in the 1990s, reactive oxygen species have been recognized to be involved in reversible structural alterations of molecules: The homeostatic modulation of oxidant levels is a highly efficient mechanism that allows all cells to tightly control their redox status within a very narrow range. Especially the activity of the Rel/NF-kB family of transcriptional factors that regulate responses in inflammation, reperfusion injury and apoptosis is controlled by intracellular reactive oxygen species levels. Our understanding of how these transcriptional factors are negatively or positively regulated by oxidative stress has since greatly increased. Questions for future investigation center on the modulation of oxidative stress by personal genome information for the prevention of several pathologic states.
Author: Toshikazu Yoshikawa
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805572301
Category : Medical
Languages : en
Pages : 191
Get Book Here
Book Description
In the 1980s, biochemists and biologists were attracted by the role of reactive oxygen species in the irreversible damage or modification of the structure of biological molecules. However, in the 1990s, reactive oxygen species have been recognized to be involved in reversible structural alterations of molecules: The homeostatic modulation of oxidant levels is a highly efficient mechanism that allows all cells to tightly control their redox status within a very narrow range. Especially the activity of the Rel/NF-kB family of transcriptional factors that regulate responses in inflammation, reperfusion injury and apoptosis is controlled by intracellular reactive oxygen species levels. Our understanding of how these transcriptional factors are negatively or positively regulated by oxidative stress has since greatly increased. Questions for future investigation center on the modulation of oxidative stress by personal genome information for the prevention of several pathologic states.
Author: Pinar Atukeren
Publisher: BoD – Books on Demand
ISBN: 1789230861
Category : Science
Languages : en
Pages : 158
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Book Description
Oxidative stress plays a crucial role in the pathophysiology of various diseases when there is a disruption of the intracellular redox balance and the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) react with molecular targets including proteins, lipids, and nucleic acids contributing to mitochondrial injury and cellular dysfunction. This book intends to provide the readers with an extensive overview of the novel approaches and prospects based on oxidative and nitrosative stress in the pathophysiology of various diseases and in the current treatment strategies with antioxidants.
Author: Jordi Gracia-Sancho
Publisher: Academic Press
ISBN: 0128093005
Category : Medical
Languages : en
Pages : 396
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Book Description
Gastrointestinal Tissue: Oxidative Stress and Dietary Antioxidants brings together leading experts from world renowned institutions, combining the basic mechanisms of gastrointestinal diseases with information regarding new and alternative treatments. The processes within the science of oxidative stress are described in concert with other processes, including apoptosis, cell signaling and receptor mediated responses, further recognizing that diseases are often multifactorial with oxidative stress as a component. By combining the critical molecular processes underlying free radical mediated pathologies and the role of dietary antioxidant molecules, a connection is made that helps advance therapies and the prevention of gastrointestinal pathological processes. This important reference is well designed with two complementary sections. Section One, Oxidative Stress and Gastroenterology, covers the basic processes of oxidative stress from molecular biology to whole organs, the gastrointestinal anatomy and sources of oxidative stress and free radicals and their products in gastrointestinal diseases. Section Two, Antioxidants and Gastroenterology covers antioxidants in foods, including plants and components. - Covers the science of oxidative stress in gastrointestinal tissue and associated conditions and scenarios - Provides information on optimal levels for human consumption of antioxidants, suggested requirements per day, recommended dietary allowances and curative/preventive effects of dietary antioxidants - Presents an easy to reference guide with two complementary sections that discuss the pathophysiology of gastrointestinal diseases in relation to oxidative stress and antioxidant therapies
Author: Paola Tonino
Publisher: BoD – Books on Demand
ISBN: 9533073756
Category : Medical
Languages : en
Pages : 312
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Book Description
This book is a comprehensive overview of invited contributions on Helicobacter pylori infection in gastritis and gastric carcinogenesis. The first part of the book covers topics related to the pathophysiology of gastric mucosal defense system and gastritis including the gastroprotective function of the mucus, the capsaicin-sensitive afferent nerves and the oxidative stress pathway involved in inflammation, apoptosis and autophagy in H. pylori related gastritis. The next chapters deal with molecular pathogenesis and treatment, which consider the role of neuroendocrine cells in gastric disease, DNA methylation in H. pylori infection, the role of antioxidants and phytotherapy in gastric disease. The final part presents the effects of cancer risk factors associated with H. pylori infection. These chapters discuss the serum pepsinogen test, K-ras mutations, cell kinetics, and H. pylori lipopolysaccharide, as well as the roles of several bacterial genes (cagA, cagT, vacA and dupA) as virulence factors in gastric cancer, and the gastrokine-1 protein in cancer progression.
Author: Sajal Chakraborti
Publisher: Springer
ISBN: 9789811387623
Category : Science
Languages : en
Pages : 0
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Book Description
This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.
Author: Jose Antonio Morales-Gonzalez
Publisher: BoD – Books on Demand
ISBN: 953511123X
Category : Science
Languages : en
Pages : 516
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Book Description
This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.
Author: Yuji Naito
Publisher: Karger Medical and Scientific Publishers
ISBN: 380559609X
Category : Medical
Languages : en
Pages : 185
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Book Description
There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.
Author: Hafiz Ansar Rasul Suleria
Publisher: CRC Press
ISBN: 0429511809
Category : Medical
Languages : en
Pages : 324
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Book Description
Phytochemicals from Medicinal Plants: Scope, Applications and Potential Health Claims explores the importance of medicinal plants and their potential benefits for human health. This book looks at bioactive compounds from medicinal plants, the health benefits of bioactive compounds, the applications of plant-based products in the food and pharmaceutical industries. The first section discusses available sources of bioactive compounds from medicinal plants, biochemistry, structural composition, potential biological activities, and how bioactive molecules are isolated from medicinal plants. The authors examine the applications of bioactive molecules from a health perspective, looking at the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany/and medicinal properties, and also present a novel dietary approach for disease management. The book goes on to examine the plant-based products are used and can be used in various sectors of the food and pharmaceutical industries.
Author: Irwin M. Arias
Publisher: John Wiley & Sons
ISBN: 1119436826
Category : Medical
Languages : en
Pages : 1156
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Book Description
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
