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Author: Sukrit Rajpal
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Nanotechnology enable medicine (nanomedicine) is expected to be the next advent of the health care market, facilitating efficient, safe, and personalized therapies. But there has been limited success penetrating the market. Despite numerous publications demonstrating the utility of nanoparticle platforms for drug delivery, analyses on commercial viability show there are several challenges to be addressed. This thesis work addresses some of these challenges, with a focus on ocular drug delivery. Topical administration is the most popular route of ocular drug delivery. However, only 5% of the administered dose is bioavailable for action at the target site, while the remaining 95% is removed via blinking, nasolacrimal drainage, or degradation. Frequent administrations of concentrated solutions are required to overcome these barriers to maintain therapeutic concentrations. Self-assembled mucoadhesive polymer nanoparticles (MNPs) composed of a poly(lactic acid) core, and dextran corona functionalized with phenylboronic acid have been successful in addressing some of these challenges for ocular drug delivery. This work is intended to optimize the commercial viability of these nanoparticle drug carriers. A review of the current state of nanomedicine for ocular drug delivery aimed at improving retention on the ocular surface is presented. The manufacturing process of the mucoadhesive block copolymer is investigated and optimized resulting in significant time and cost savings. In addition, a method for modification of carbohydrates without the use of organic solvents based on solid-state chemistry is described. Strategies to improve the shelf-life of the colloid suspension are explored and optimized for the MNPs with pharmacopoeia guidelines. A novel method of utilizing freeze-drying to drive self-assembly of polymer micelles is demonstrated. Further steps to improve the commercial viability and success of the MNP platform are discussed in the conclusions.
Author: Sukrit Rajpal
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Nanotechnology enable medicine (nanomedicine) is expected to be the next advent of the health care market, facilitating efficient, safe, and personalized therapies. But there has been limited success penetrating the market. Despite numerous publications demonstrating the utility of nanoparticle platforms for drug delivery, analyses on commercial viability show there are several challenges to be addressed. This thesis work addresses some of these challenges, with a focus on ocular drug delivery. Topical administration is the most popular route of ocular drug delivery. However, only 5% of the administered dose is bioavailable for action at the target site, while the remaining 95% is removed via blinking, nasolacrimal drainage, or degradation. Frequent administrations of concentrated solutions are required to overcome these barriers to maintain therapeutic concentrations. Self-assembled mucoadhesive polymer nanoparticles (MNPs) composed of a poly(lactic acid) core, and dextran corona functionalized with phenylboronic acid have been successful in addressing some of these challenges for ocular drug delivery. This work is intended to optimize the commercial viability of these nanoparticle drug carriers. A review of the current state of nanomedicine for ocular drug delivery aimed at improving retention on the ocular surface is presented. The manufacturing process of the mucoadhesive block copolymer is investigated and optimized resulting in significant time and cost savings. In addition, a method for modification of carbohydrates without the use of organic solvents based on solid-state chemistry is described. Strategies to improve the shelf-life of the colloid suspension are explored and optimized for the MNPs with pharmacopoeia guidelines. A novel method of utilizing freeze-drying to drive self-assembly of polymer micelles is demonstrated. Further steps to improve the commercial viability and success of the MNP platform are discussed in the conclusions.
Author: Bhupinder Singh
Publisher: LAP Lambert Academic Publishing
ISBN: 9783838394251
Category : Drug delivery systems
Languages : en
Pages : 248
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Book Description
The work embodies development and systematic optimization of oral controlled release (CR) mucoadhesive hydrophilic matrices of atenolol using "Design of Experiments". A central composite design was used to optimize drug release profile and bioadhesive strength. Two polymers, namely, Carbopol 934P and sodium CMC, were taken as synergistic factors. The 3-D response surfaces and 2-D contour plots indicated significant effect of both the polymers on ex vivo bioadhesive strength of tablet against porcine gastric mucosa, diffusional release exponent and drug release extension. The optimized drug delivery formulation was selected by feasibility and grid searches based on maximization of the response variables. Validation of drug delivery optimization study using experimental runs indicated high prognostic ability of the chosen experimental design. Besides unraveling the effect of the two factors on various response variables, the study helped in finding the "optimized" formulation with excellent bioadhesive strength and extended release for 24 h, holding immense promise for once-a-day gastroretentive CR formulation and minimizing fluctuations in plasma drug levels.
Author: Vitaliy V. Khutoryanskiy
Publisher: MDPI
ISBN: 3039287524
Category : Medical
Languages : en
Pages : 206
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Book Description
Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections. This book represents a collection of reviews and original research articles in the area of mucoadhesive polymers and dosage forms. It covers the design of mucoadhesive forms from commercially-available water-soluble polymers, their mixture and complexes as well as some materials, whose mucoadhesive properties were enhanced through chemical modification. With contributions from leading experts in mucoadhesive polymers and formulations, this book will be a very useful source of information for researchers in polymer, pharmaceutical and formulation sciences.
Author: Redouane Borsali
Publisher: Springer Science & Business Media
ISBN: 140204464X
Category : Science
Languages : en
Pages : 1490
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Book Description
This 2-volume set includes extensive discussions of scattering techniques (light, neutron and X-ray) and related fluctuation and grating techniques that are at the forefront of this field. Most of the scattering techniques are Fourier space techniques. Recent advances have seen the development of powerful direct imaging methods such as atomic force microscopy and scanning probe microscopy. In addition, techniques that can be used to manipulate soft matter on the nanometer scale are also in rapid development. These include the scanning probe microscopy technique mentioned above as well as optical and magnetic tweezers.
Author: Ashim K. Mitra
Publisher: CRC Press
ISBN: 9780367446765
Category :
Languages : en
Pages : 847
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Book Description
The second edition of this text assembles significant ophthalmic advances and encompasses breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery.
Author: Vijay Kumar Thakur
Publisher: Springer
ISBN: 9811060835
Category : Technology & Engineering
Languages : en
Pages : 412
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Book Description
This book addresses a range of synthesis and characterization techniques that are critical for tailoring and broadening the various aspects of polymer gels, as well as the numerous advantages that polymer gel-based materials offer. It presents a comprehensive collection of chapters on the recent advances and developments in the science and fundamentals of both synthetic and natural polymer-based gels. Topics covered include: synthesis and structure of physically/chemically cross-linked polymer-gels/polymeric nanogels; gel formation through non-covalent cross-linking; molecular design and characterization; polysaccharide-based polymer gels: synthesis, characterization, and properties; modified polysaccharide gels: silica-based polymeric gels as platforms for the delivery of pharmaceuticals; gel-based approaches in genomic and proteomic sciences; emulgels in drug delivery; and organogels. The book provides a cutting-edge resource for researchers and scientists working in various fields involving polymers, biomaterials, bio-nanotechnology and functional materials.
Author: Sarwar Beg
Publisher: CRC Press
ISBN: 1000731324
Category : Business & Economics
Languages : en
Pages : 382
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Book Description
Pharmaceutical manufacturers are constantly facing quality crises of drug products, leading to an escalating number of product recalls and rejects. Due to the involvement of multiple factors, the goal of achieving consistent product quality is always a great challenge for pharmaceutical scientists. This volume addresses this challenge by using the Quality by Design (QbD) concept, which was instituted to focus on the systematic development of drug products with predefined objectives to provide enhanced product and process understanding. This volume presents and discusses the vital precepts underlying the efficient, effective, and cost effective development of pharmaceutical drug products. It focuses on the adoption of systematic quality principles of pharmaceutical development, which is imperative in achieving continuous improvement in end-product quality and also leads to reducing cost, time, and effort, while meeting regulatory requirements. The volume covers the important new advances in the development of solid oral dosage forms, modified release oral dosage forms, parenteral dosage forms, semisolid dosage forms, transdermal drug, delivery systems, inhalational dosage forms, ocular drug delivery systems, nanopharmaceutical products, and nanoparticles for oral delivery.
Author: Marcos Luciano Bruschi
Publisher: Woodhead Publishing
ISBN: 0081001126
Category : Medical
Languages : en
Pages : 208
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Book Description
Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications
Author: Prashant Kesharwani
Publisher: Woodhead Publishing
ISBN: 0323886299
Category : Technology & Engineering
Languages : en
Pages : 716
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Book Description
Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation. Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery Describes the various polymer types used in the synthesis and characterization of polymeric micelles Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more
Author: Dipankar Chattopadhyay
Publisher: Elsevier
ISBN: 0323993591
Category : Technology & Engineering
Languages : en
Pages : 674
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Book Description
This book covers fundamental aspects in the preparation of polymeric in-situ, stimuli-responsive hydrogels; the properties, characterization, chemistry, and fabrication of these hydrogels is detailed, helping the reader to select the most appropriate material and design for the desired application. The book goes on to review applications in ophthalmic drug delivery, covering in vitro and in vivo models, animal models, preclinical testing, patents and more. Stimuli-responsive Hydrogels for Ophthalmic Drug Delivery is a must-have reference for researchers and academics in the fields of materials science, biomaterials, pharmacology and polymer science, with an interest in clinical aspects of hydrogel design and application. Provides step-by-step coverage for engineering in-situ and stimuli-responsive hydrogels, from design, characterization, and toxicity considerations to fabrication, process optimization, and drug release kinetics Utilizes an interdisciplinary approach, bringing together authors from pharmacology, polymer science, and medical backgrounds Details the advantages and challenges of using stimuli-responsive hydrogels for ophthalmic drug delivery, with a focus on clinical translation
