Author: LTC Clifton H. Deringer Jr. USA (Ret.) “Tip”
Publisher: Dorrance Publishing
ISBN: 1480930954
Category : Fiction
Languages : en
Pages : 108
Book Description
One Year in the Life of a Dog By LTC Clifton H. Deringer Jr. USA (Ret.) “Tip” One Year in the Life of a Dog follows the story of Friend, a dog that can hear the thoughts of humans and respond telepathically. There are humans who are gifted with understanding the telepathy in animals and a university student who interviews Friend is blessed with such a gift. The book follows their interactions and various events that occur within their world. Intrigue, deception, kidnapping, and prejudice are woven seamlessly with love, understanding, sympathy, and acceptance. Barney and Jeff, Friend’s owners, are a homosexual, bi-racial couple. Seeing their lives from Friend’s point of view speaks on many levels to how ridiculous and outdated prejudice is. Barney and Jeff are just as loving and fulfilled as any other happy couple. Many of the characters with whom Friend interacts are not open to the couple’s way of life, but quickly realize their mistake when they see how lovely Barney and Jeff truly are. There are harrowing situations that breed a deeper understanding of the differences between people; this book is truly a tool to teach readers to love all, despite the different ways the characters live their lives.
One Year in the Life of a Dog
Author: LTC Clifton H. Deringer Jr. USA (Ret.) “Tip”
Publisher: Dorrance Publishing
ISBN: 1480930954
Category : Fiction
Languages : en
Pages : 108
Book Description
One Year in the Life of a Dog By LTC Clifton H. Deringer Jr. USA (Ret.) “Tip” One Year in the Life of a Dog follows the story of Friend, a dog that can hear the thoughts of humans and respond telepathically. There are humans who are gifted with understanding the telepathy in animals and a university student who interviews Friend is blessed with such a gift. The book follows their interactions and various events that occur within their world. Intrigue, deception, kidnapping, and prejudice are woven seamlessly with love, understanding, sympathy, and acceptance. Barney and Jeff, Friend’s owners, are a homosexual, bi-racial couple. Seeing their lives from Friend’s point of view speaks on many levels to how ridiculous and outdated prejudice is. Barney and Jeff are just as loving and fulfilled as any other happy couple. Many of the characters with whom Friend interacts are not open to the couple’s way of life, but quickly realize their mistake when they see how lovely Barney and Jeff truly are. There are harrowing situations that breed a deeper understanding of the differences between people; this book is truly a tool to teach readers to love all, despite the different ways the characters live their lives.
Publisher: Dorrance Publishing
ISBN: 1480930954
Category : Fiction
Languages : en
Pages : 108
Book Description
One Year in the Life of a Dog By LTC Clifton H. Deringer Jr. USA (Ret.) “Tip” One Year in the Life of a Dog follows the story of Friend, a dog that can hear the thoughts of humans and respond telepathically. There are humans who are gifted with understanding the telepathy in animals and a university student who interviews Friend is blessed with such a gift. The book follows their interactions and various events that occur within their world. Intrigue, deception, kidnapping, and prejudice are woven seamlessly with love, understanding, sympathy, and acceptance. Barney and Jeff, Friend’s owners, are a homosexual, bi-racial couple. Seeing their lives from Friend’s point of view speaks on many levels to how ridiculous and outdated prejudice is. Barney and Jeff are just as loving and fulfilled as any other happy couple. Many of the characters with whom Friend interacts are not open to the couple’s way of life, but quickly realize their mistake when they see how lovely Barney and Jeff truly are. There are harrowing situations that breed a deeper understanding of the differences between people; this book is truly a tool to teach readers to love all, despite the different ways the characters live their lives.
The Year of the Puppy
Author: Alexandra Horowitz
Publisher: Penguin
ISBN: 0593298020
Category : Pets
Languages : en
Pages : 321
Book Description
“What Mr. Rogers was to children, Alexandra Horowitz is to dogs: a wise and patient observer who seeks to intimately know a creature... Her chapters, packed with close observations about canine cognition and behavior, are mini-mood lifters." —NPR, Maureen Corrigan on Fresh Air What is it like to be a puppy? Author of the classic Inside of a Dog, Alexandra Horowitz tries to find out, spending a year scrutinizing her puppy’s daily existence and poring over the science of early dog development Few of us meet our dogs at Day One. The dog who will, eventually, become an integral part of our family, our constant companion and best friend, is born without us into a family of her own. A puppy's critical early development into the dog we come to know is usually missed entirely. Dog researcher Alexandra Horowitz aimed to change that with her family's new pup, Quiddity (Quid). In this scientific memoir, she charts Quid's growth from wee grub to boisterous sprite, from her birth to her first birthday. Horowitz follows Quid's first weeks with her mother and ten roly-poly littermates, and then each week after the puppy joins her household of three humans, two large dogs, and a wary cat. She documents the social and cognitive milestones that so many of us miss in our puppies' lives, when caught up in the housetraining and behavioral training that easily overwhelms the first months of a dog's life with a new family. In focusing on training a dog to behave, we mostly miss the radical development of a puppy into themselves—through the equivalent of infancy, childhood, young adolescence, and teenager-hood. By slowing down to observe Quid from week to week, The Year of the Puppy makes new sense of a dog's behavior in a way that is missed when the focus is only on training. Horowitz keeps a lens on the puppy's point of view—how they (begin to) see and smell the world, make meaning of it, and become an individual personality. She's there when the puppies first open their eyes, first start to recognize one another and learn about cats, sheep, and people; she sees them from their first play bows to puberty. Horowitz also draws from the ample research in the fields of dog and human development to draw analogies between a dog's first year and the growing child—and to note where they diverge. The Year of the Puppy is indispensable for anyone navigating their way through the frustrating, amusing, and ultimately delightful first year of a puppy’s life.
Publisher: Penguin
ISBN: 0593298020
Category : Pets
Languages : en
Pages : 321
Book Description
“What Mr. Rogers was to children, Alexandra Horowitz is to dogs: a wise and patient observer who seeks to intimately know a creature... Her chapters, packed with close observations about canine cognition and behavior, are mini-mood lifters." —NPR, Maureen Corrigan on Fresh Air What is it like to be a puppy? Author of the classic Inside of a Dog, Alexandra Horowitz tries to find out, spending a year scrutinizing her puppy’s daily existence and poring over the science of early dog development Few of us meet our dogs at Day One. The dog who will, eventually, become an integral part of our family, our constant companion and best friend, is born without us into a family of her own. A puppy's critical early development into the dog we come to know is usually missed entirely. Dog researcher Alexandra Horowitz aimed to change that with her family's new pup, Quiddity (Quid). In this scientific memoir, she charts Quid's growth from wee grub to boisterous sprite, from her birth to her first birthday. Horowitz follows Quid's first weeks with her mother and ten roly-poly littermates, and then each week after the puppy joins her household of three humans, two large dogs, and a wary cat. She documents the social and cognitive milestones that so many of us miss in our puppies' lives, when caught up in the housetraining and behavioral training that easily overwhelms the first months of a dog's life with a new family. In focusing on training a dog to behave, we mostly miss the radical development of a puppy into themselves—through the equivalent of infancy, childhood, young adolescence, and teenager-hood. By slowing down to observe Quid from week to week, The Year of the Puppy makes new sense of a dog's behavior in a way that is missed when the focus is only on training. Horowitz keeps a lens on the puppy's point of view—how they (begin to) see and smell the world, make meaning of it, and become an individual personality. She's there when the puppies first open their eyes, first start to recognize one another and learn about cats, sheep, and people; she sees them from their first play bows to puberty. Horowitz also draws from the ample research in the fields of dog and human development to draw analogies between a dog's first year and the growing child—and to note where they diverge. The Year of the Puppy is indispensable for anyone navigating their way through the frustrating, amusing, and ultimately delightful first year of a puppy’s life.
Wag
Author: Zazie Todd
Publisher: Greystone Books Ltd
ISBN: 1771643803
Category : Pets
Languages : en
Pages : 269
Book Description
As seen in The New York Times, People, SLATE, Psychology Today "[A] must-have guide to improving your dog's life."—Modern Dog Magazine Whether you are training a new puppy, considering adopting a dog, researching dog breeds, or simply curious about your own dog's happiness and behavior, Wag has all the answers-and then some. Respected dog trainer and social psychologist, Zazie Todd, demystifies the inner life of canines and shares recommendations from leading veterinarians, researchers, and trainers to help you cultivate a rewarding and respectful relationship with your dog-which offers many benefits for you, your family, and your four-legged friend. Inside this engaging, practical book, readers will find: A Check List for a Happy Dog Enrichment exercises How to socialize and train a new puppy How to reduce fear and anxiety in dogs Tips for visiting the vet Information on aging dogs Expert interviews with vets and psychologists And so much more! "Dog owners and those considering becoming one should appreciate Todd's substantial insight into how dogs and humans relate to one another."—Publishers Weekly
Publisher: Greystone Books Ltd
ISBN: 1771643803
Category : Pets
Languages : en
Pages : 269
Book Description
As seen in The New York Times, People, SLATE, Psychology Today "[A] must-have guide to improving your dog's life."—Modern Dog Magazine Whether you are training a new puppy, considering adopting a dog, researching dog breeds, or simply curious about your own dog's happiness and behavior, Wag has all the answers-and then some. Respected dog trainer and social psychologist, Zazie Todd, demystifies the inner life of canines and shares recommendations from leading veterinarians, researchers, and trainers to help you cultivate a rewarding and respectful relationship with your dog-which offers many benefits for you, your family, and your four-legged friend. Inside this engaging, practical book, readers will find: A Check List for a Happy Dog Enrichment exercises How to socialize and train a new puppy How to reduce fear and anxiety in dogs Tips for visiting the vet Information on aging dogs Expert interviews with vets and psychologists And so much more! "Dog owners and those considering becoming one should appreciate Todd's substantial insight into how dogs and humans relate to one another."—Publishers Weekly
A Dog Year
Author: Jon Katz
Publisher: Villard
ISBN: 1588361144
Category : Pets
Languages : en
Pages : 150
Book Description
“Change loves me, defines and stalks me like a laser-guided smart bomb. It comes at me in all forms, suddenly and with enormous impact, from making shifts in work to having and raising a kid to buying a cabin on a distant mountaintop. Sometimes, change comes on four legs.” In his popular and widely praised Running to the Mountain, Jon Katz wrote of the strength and support he found in the massive forms of his two yellow Labrador retrievers, Julius and Stanley. When the Labs were six and seven, a breeder who’d read his book contacted Katz to say she had a dog that was meant for him—a two-year-old border collie named Devon, well bred but high-strung and homeless. Katz already had a full canine complement, but instinct overruled reason, and soon thereafter he brought Devon home. A Dog Year: Twelve Months, Four Dogs, and Me is the story of how Devon and Jon—and Julius and Stanley—came to terms with each other. It shows how a man discovered a lot about himself through one dog (and then another) whose temperament seemed as different from his own as day is from night. It is a story of trust and understanding, of life and death, of continuity and change. It is by turns insightful, hilarious, and deeply moving. BONUS: This edition contains an excerpt from Jon Katz's Going Home.
Publisher: Villard
ISBN: 1588361144
Category : Pets
Languages : en
Pages : 150
Book Description
“Change loves me, defines and stalks me like a laser-guided smart bomb. It comes at me in all forms, suddenly and with enormous impact, from making shifts in work to having and raising a kid to buying a cabin on a distant mountaintop. Sometimes, change comes on four legs.” In his popular and widely praised Running to the Mountain, Jon Katz wrote of the strength and support he found in the massive forms of his two yellow Labrador retrievers, Julius and Stanley. When the Labs were six and seven, a breeder who’d read his book contacted Katz to say she had a dog that was meant for him—a two-year-old border collie named Devon, well bred but high-strung and homeless. Katz already had a full canine complement, but instinct overruled reason, and soon thereafter he brought Devon home. A Dog Year: Twelve Months, Four Dogs, and Me is the story of how Devon and Jon—and Julius and Stanley—came to terms with each other. It shows how a man discovered a lot about himself through one dog (and then another) whose temperament seemed as different from his own as day is from night. It is a story of trust and understanding, of life and death, of continuity and change. It is by turns insightful, hilarious, and deeply moving. BONUS: This edition contains an excerpt from Jon Katz's Going Home.
A Dog's Purpose
Author: W. Bruce Cameron
Publisher: Forge Books
ISBN: 1429960272
Category : Fiction
Languages : en
Pages : 320
Book Description
A Dog’s Purpose—the #1 New York Times bestseller and major motion picture—is a perfect gift to introduce dog lovers to this wonderful series. Based on the beloved bestselling novel by W. Bruce Cameron, A Dog’s Purpose, from director Lasse Hallström (The Cider House Rules, Dear John, The 100-Foot Journey), shares the soulful and surprising story of one devoted dog (voiced by Josh Gad) who finds the meaning of his own existence through the lives of the humans he teaches to laugh and love. The family film told from the dog’s perspective also stars Britt Robertson, KJ Apa, John Ortiz, Peggy Lipton, Juliet Rylance, Luke Kirby, Pooch Hall and Dennis Quaid. A Dog’s Purpose is produced by Gavin Polone (Zombieland, TV’s Gilmore Girls). The film from Amblin Entertainment and Walden Media will be distributed by Universal Pictures. Screenplay by W. Bruce Cameron & Cathryn Michon and Audrey Wells and Maya Forbes & Wally Wolodarsky. Heartwarming, insightful, and often laugh-out-loud funny, A Dog's Purpose is not only the emotional and hilarious story of a dog's many lives, but also a dog's-eye commentary on human relationships and the unbreakable bonds between man and man's best friend. This moving and beautifully crafted story teaches us that love never dies, that our true friends are always with us, and that every creature on earth is born with a purpose. Bailey's story continues in A Dog's Journey, the charming New York Times and USA Today bestselling direct sequel to A Dog's Purpose. A Dog's Purpose Series #1 A Dog’s Purpose #2 A Dog’s Journey #3 A Dog's Promise Books for Young Readers Ellie's Story: A Dog’s Purpose Puppy Tale Bailey’s Story: A Dog’s Purpose Puppy Tale Molly's Story: A Dog's Purpose Puppy Tale Max's Story: A Dog’s Purpose Puppy Tale Toby's Story: A Dog's Purpose Puppy Tale Shelby's Story: A Dog's Way Home Novel The Rudy McCann Series The Midnight Plan of the Repo Man Repo Madness Other Novels A Dog's Way Home The Dog Master The Dogs of Christmas Emory’s Gift At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
Publisher: Forge Books
ISBN: 1429960272
Category : Fiction
Languages : en
Pages : 320
Book Description
A Dog’s Purpose—the #1 New York Times bestseller and major motion picture—is a perfect gift to introduce dog lovers to this wonderful series. Based on the beloved bestselling novel by W. Bruce Cameron, A Dog’s Purpose, from director Lasse Hallström (The Cider House Rules, Dear John, The 100-Foot Journey), shares the soulful and surprising story of one devoted dog (voiced by Josh Gad) who finds the meaning of his own existence through the lives of the humans he teaches to laugh and love. The family film told from the dog’s perspective also stars Britt Robertson, KJ Apa, John Ortiz, Peggy Lipton, Juliet Rylance, Luke Kirby, Pooch Hall and Dennis Quaid. A Dog’s Purpose is produced by Gavin Polone (Zombieland, TV’s Gilmore Girls). The film from Amblin Entertainment and Walden Media will be distributed by Universal Pictures. Screenplay by W. Bruce Cameron & Cathryn Michon and Audrey Wells and Maya Forbes & Wally Wolodarsky. Heartwarming, insightful, and often laugh-out-loud funny, A Dog's Purpose is not only the emotional and hilarious story of a dog's many lives, but also a dog's-eye commentary on human relationships and the unbreakable bonds between man and man's best friend. This moving and beautifully crafted story teaches us that love never dies, that our true friends are always with us, and that every creature on earth is born with a purpose. Bailey's story continues in A Dog's Journey, the charming New York Times and USA Today bestselling direct sequel to A Dog's Purpose. A Dog's Purpose Series #1 A Dog’s Purpose #2 A Dog’s Journey #3 A Dog's Promise Books for Young Readers Ellie's Story: A Dog’s Purpose Puppy Tale Bailey’s Story: A Dog’s Purpose Puppy Tale Molly's Story: A Dog's Purpose Puppy Tale Max's Story: A Dog’s Purpose Puppy Tale Toby's Story: A Dog's Purpose Puppy Tale Shelby's Story: A Dog's Way Home Novel The Rudy McCann Series The Midnight Plan of the Repo Man Repo Madness Other Novels A Dog's Way Home The Dog Master The Dogs of Christmas Emory’s Gift At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
The Year of the Dog
Author: Grace Lin
Publisher: Little, Brown Books for Young Readers
ISBN: 031603097X
Category : Juvenile Fiction
Languages : en
Pages : 163
Book Description
This funny and profound debut novel by prolific illustrator Lin tells the story of young Pacy who, as she celebrates the Chinese New Year with her family, discovers this is the year she is supposed to "find herself." Illustrations.
Publisher: Little, Brown Books for Young Readers
ISBN: 031603097X
Category : Juvenile Fiction
Languages : en
Pages : 163
Book Description
This funny and profound debut novel by prolific illustrator Lin tells the story of young Pacy who, as she celebrates the Chinese New Year with her family, discovers this is the year she is supposed to "find herself." Illustrations.
Dogs on the Trail
Author: Blair Braverman
Publisher: HarperCollins
ISBN: 0063066270
Category : Sports & Recreation
Languages : en
Pages : 148
Book Description
Please note this is a fixed format ebook. Type size and other formatting features on your eReader are not usable on this file. Your device should allow you to enlarge an individual paragraph by double clicking it. Once you have done so, you may be able to further zoom in and use the “turn page” feature to move to the next paragraph, depending on your device. A delightful photographic journey into a year in the life of a team of sled dogs, based on Braverman’s wildly popular Twitter feed When Blair Braverman started posting pictures of her dog team on Twitter, she had no idea the response she would get. Being a musher, after all, isn’t just about racing—raising dogs from puppyhood to retirement (and beyond) is a full-time job. She and her husband, musher Quince Mountain, wanted to share stories about life with their dog team. And not just the big stuff, like expeditions and wild animal encounters, but also the everyday things: the challenge of storing a thousand pounds of raw meat, scouting new trails with the dogs, the decisions that go into putting a team together, how she trains puppies to be brave. These were goofy stories, scary stories, heartfelt stories, stories that clearly connected with people and kept going viral. Inspired by those connections, Dogs on the Trail is a chronicle of a year in the life of their dog team. Beginning in the fall as the weather starts to cool, training on both dry land and in the snow, then camping and racing. Spring brings mud—lousy for sledding, but the dogs love it. And summer is the season of puppies. The book ends on a beginning, in anticipation of the adventurous lives that the new pups have in store. An irresistible adventure, Dogs on the Trail will delight and entertain while taking you inside a musher’s world, and showing you why the wilderness isn’t simply a place to visit but also a home to return to.
Publisher: HarperCollins
ISBN: 0063066270
Category : Sports & Recreation
Languages : en
Pages : 148
Book Description
Please note this is a fixed format ebook. Type size and other formatting features on your eReader are not usable on this file. Your device should allow you to enlarge an individual paragraph by double clicking it. Once you have done so, you may be able to further zoom in and use the “turn page” feature to move to the next paragraph, depending on your device. A delightful photographic journey into a year in the life of a team of sled dogs, based on Braverman’s wildly popular Twitter feed When Blair Braverman started posting pictures of her dog team on Twitter, she had no idea the response she would get. Being a musher, after all, isn’t just about racing—raising dogs from puppyhood to retirement (and beyond) is a full-time job. She and her husband, musher Quince Mountain, wanted to share stories about life with their dog team. And not just the big stuff, like expeditions and wild animal encounters, but also the everyday things: the challenge of storing a thousand pounds of raw meat, scouting new trails with the dogs, the decisions that go into putting a team together, how she trains puppies to be brave. These were goofy stories, scary stories, heartfelt stories, stories that clearly connected with people and kept going viral. Inspired by those connections, Dogs on the Trail is a chronicle of a year in the life of their dog team. Beginning in the fall as the weather starts to cool, training on both dry land and in the snow, then camping and racing. Spring brings mud—lousy for sledding, but the dogs love it. And summer is the season of puppies. The book ends on a beginning, in anticipation of the adventurous lives that the new pups have in store. An irresistible adventure, Dogs on the Trail will delight and entertain while taking you inside a musher’s world, and showing you why the wilderness isn’t simply a place to visit but also a home to return to.
A Year in the Life
Author: Lucy Leonelli
Publisher: Unbound Publishing
ISBN: 1800180519
Category : Biography & Autobiography
Languages : en
Pages : 313
Book Description
After nearly a decade of dutifully climbing the corporate ladder to become a partner in a headhunting firm, Lucy Leonelli was feeling restless in a life that was seemingly mapped out for her, and she could not shake the sense that she was missing out on something... something out there. Realising that the answer was right in front of her – in a country so full of clandestine communities and colourful, eccentric characters – Lucy made the daring decision to hit the pause button on her career and hang up her suit in favour of a year exploring twenty-six wildly different subcultures. Over the next twelve months, she lived with battle re-enactors, circus performers, hill baggers, Morris dancers, naturists, trainspotters, yogis, zeitgeist political activists and more, experiencing first-hand their social rituals and customs in the hope that, somewhere along the way, she might just uncover the most authentic version of herself. A Year in the Life charts Lucy’s adventure as she sang naked karaoke with naturists, jumped from one very high place to another with parkour daredevils, partied in tight latex with self-proclaimed vampires and fought the undead in an epic LARP battle. It tells of the importance of community in an increasingly isolating society; of the unquenchable human thirst for a sense of belonging; of how misguided our own prejudices can be; and of how when we open the door to others, we might just learn something about ourselves.
Publisher: Unbound Publishing
ISBN: 1800180519
Category : Biography & Autobiography
Languages : en
Pages : 313
Book Description
After nearly a decade of dutifully climbing the corporate ladder to become a partner in a headhunting firm, Lucy Leonelli was feeling restless in a life that was seemingly mapped out for her, and she could not shake the sense that she was missing out on something... something out there. Realising that the answer was right in front of her – in a country so full of clandestine communities and colourful, eccentric characters – Lucy made the daring decision to hit the pause button on her career and hang up her suit in favour of a year exploring twenty-six wildly different subcultures. Over the next twelve months, she lived with battle re-enactors, circus performers, hill baggers, Morris dancers, naturists, trainspotters, yogis, zeitgeist political activists and more, experiencing first-hand their social rituals and customs in the hope that, somewhere along the way, she might just uncover the most authentic version of herself. A Year in the Life charts Lucy’s adventure as she sang naked karaoke with naturists, jumped from one very high place to another with parkour daredevils, partied in tight latex with self-proclaimed vampires and fought the undead in an epic LARP battle. It tells of the importance of community in an increasingly isolating society; of the unquenchable human thirst for a sense of belonging; of how misguided our own prejudices can be; and of how when we open the door to others, we might just learn something about ourselves.
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
Author: Johan Gabrielsson
Publisher: CRC Press
ISBN: 9789186274924
Category : Medical
Languages : en
Pages : 926
Book Description
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Publisher: CRC Press
ISBN: 9789186274924
Category : Medical
Languages : en
Pages : 926
Book Description
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Coping in Politics with Indeterminate Norms
Author: Benjamin Gregg
Publisher: State University of New York Press
ISBN: 9780791486597
Category : Social Science
Languages : en
Pages : 224
Book Description
Are social equity, political fairness, and legal justice possible within a liberal political order, even if norms are indeterminate? The modern world is distinguished by both its complexity and the absence of a single theory, principle, or tradition with the authority to constrain us. Coping in Politics with Indeterminate Norms demonstrates that while moral validity is relative rather than absolute, and cultural meanings local rather than universal, social integration and democratic politics are still attainable goals. Benjamin Gregg fashions a theory that combines proceduralism with pragmatism—an "enlightened localism"—that adjudicates among competing normative commitments and interpretations using local criteria in the absence of universal standards. The theory is applied to three empirical domains: social criticism, public policy, and law and morality.
Publisher: State University of New York Press
ISBN: 9780791486597
Category : Social Science
Languages : en
Pages : 224
Book Description
Are social equity, political fairness, and legal justice possible within a liberal political order, even if norms are indeterminate? The modern world is distinguished by both its complexity and the absence of a single theory, principle, or tradition with the authority to constrain us. Coping in Politics with Indeterminate Norms demonstrates that while moral validity is relative rather than absolute, and cultural meanings local rather than universal, social integration and democratic politics are still attainable goals. Benjamin Gregg fashions a theory that combines proceduralism with pragmatism—an "enlightened localism"—that adjudicates among competing normative commitments and interpretations using local criteria in the absence of universal standards. The theory is applied to three empirical domains: social criticism, public policy, and law and morality.