Oestrogen and Progesterone Receptor Gene Expression and Regulation in Cultured Human Breast Cancer Cells PDF Download
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Author: Ian E. Alexander
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 418
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Book Description
Author: Ian E. Alexander
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 418
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Book Description
Author: Lawanda Schief
Publisher: Page Publishing Inc
ISBN: 1642148903
Category : Health & Fitness
Languages : en
Pages : 162
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Book Description
Have you ever wondered how chemicals in the environment affect cancer? Well, this book can give you some scientific insight on how common pesticide chemicals and industrial waste can affect the growth of breast cancer cells.
Author: Alan Milburn Robinson
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 200
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Book Description
Author: Robert B. Dickson
Publisher: Springer Science & Business Media
ISBN: 146153500X
Category : Medical
Languages : en
Pages : 478
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Book Description
Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current di agnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Author: Anders Berkenstam
Publisher:
ISBN: 9789179008147
Category :
Languages : en
Pages : 53
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Book Description
Author: Amy M. Fowler
Publisher:
ISBN:
Category :
Languages : en
Pages : 226
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Book Description
Author: Marc E. Lippman
Publisher: Springer Science & Business Media
ISBN: 1461539404
Category : Medical
Languages : en
Pages : 455
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Book Description
In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.
Author: Shun-Yuan Jiang
Publisher:
ISBN:
Category :
Languages : en
Pages : 346
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 90
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Book Description
Progesterone receptor gene expression is induced by estrogen in MCF-7 human breast cancer cells. Although it is generally thought that estrogen-responsiveness is mediated through estrogen response elements (EREs), the progesterone receptor gene lacks an identifiable ERE. The progesterone receptor A promoter does, however, contain a half ERE/Sp 1 binding site comprised of an ERE half site upstream of two Sp 1 binding sites. We have used in vivo DNase I footprinting to demonstrate that the half ERE/Sp 1 binding site is more protected when MCF-7 cells are treated with estrogen than when cells are not exposed to hormone suggesting that the this region is involved in estrogen-regulated gene expression. The ability of the half ERE/Sp 1 binding site to confer estrogen responsiveness to a simple heterologous promoter was confirmed in transient cotransfection assays. In vitro DNase I footprinting and gel mobility shift assays demonstrated that Sp 1 present in MCF-7 nuclear extracts and purified Sp 1 protein bound to the two Sp 1 sites and that estrogen-occupied estrogen receptor enhanced Sp 1 binding. In addition to its effects on Sp 1 binding, the estrogen receptor also bound directly to the ERE half site. Taken together, these findings suggest that estrogen-occupied receptor and Sp I play a role in activation of the human progesterone receptor A promoter.
Author: Kerry L. Burnstein
Publisher: Springer Science & Business Media
ISBN: 1461509653
Category : Medical
Languages : en
Pages : 264
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Book Description
From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.
