OECD Series on Testing and Assessment Report of the Workshop on a Framework for the Development and Use Of Integrated Approaches to Testing and Assessment PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download OECD Series on Testing and Assessment Report of the Workshop on a Framework for the Development and Use Of Integrated Approaches to Testing and Assessment PDF full book. Access full book title OECD Series on Testing and Assessment Report of the Workshop on a Framework for the Development and Use Of Integrated Approaches to Testing and Assessment by OECD. Download full books in PDF and EPUB format.
Author: OECD
Publisher: OECD Publishing
ISBN: 926427474X
Category :
Languages : en
Pages : 154
Get Book Here
Book Description
This document is a report of the Workshop on a framework for the development and use of integrated approaches to testing and assessment which was held on 17-19 November 2014 in Crystal City VA, USA. This framework should provide guiding principles, and technical guidance on how results from ...
Author: OECD
Publisher: OECD Publishing
ISBN: 926427474X
Category :
Languages : en
Pages : 154
Get Book Here
Book Description
This document is a report of the Workshop on a framework for the development and use of integrated approaches to testing and assessment which was held on 17-19 November 2014 in Crystal City VA, USA. This framework should provide guiding principles, and technical guidance on how results from ...
Author: Chantra Eskes
Publisher: Springer
ISBN: 3319338269
Category : Medical
Languages : en
Pages : 418
Get Book Here
Book Description
This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264274790
Category :
Languages : en
Pages : 85
Get Book Here
Book Description
In this document the importance of mechanistic consideration in quantitative structure-activity relationship ((Q)SAR) analysis, the critical role of mechanistic consideration in improving various (Q)SAR approaches and possible integrative approaches of combining chemoinformatics and ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264891048
Category :
Languages : en
Pages : 33
Get Book Here
Book Description
The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). However, there is a need for a systematic framework to characterise the individual biological and toxicological relevance of alternative methods in assessing chemicals in predicting toxicological endpoints.
Author: Natàlia Garcia-Reyero
Publisher: Springer
ISBN: 3319660845
Category : Science
Languages : en
Pages : 429
Get Book Here
Book Description
Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264952977
Category :
Languages : en
Pages : 119
Get Book Here
Book Description
The report outlines the technical aspects of the various approaches and methodologies available with respect to the assessment of risks from combined exposures to multiple chemicals. The document draws from approaches applied and experience gained in the regulatory context and will therefore be most relevant to the regulatory authorities addressing chemicals, the regulated community and other interested stakeholders.
Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN: 9789264122215
Category : Chemical industry
Languages : en
Pages :
Get Book Here
Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221433
Category :
Languages : en
Pages : 174
Get Book Here
Book Description
This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
Author: Cynthia V. Rider
Publisher: Springer
ISBN: 3319562347
Category : Medical
Languages : en
Pages : 554
Get Book Here
Book Description
In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.
Author: Amy J. Clippinger
Publisher: Frontiers Media SA
ISBN: 2832508596
Category : Science
Languages : en
Pages : 139
Get Book Here
Book Description
