OECD Guidelines for Testing of Chemicals

OECD Guidelines for Testing of Chemicals PDF Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN: 9789264122215
Category : Chemical industry
Languages : en
Pages :

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Book Description

OECD Guidelines for Testing of Chemicals

OECD Guidelines for Testing of Chemicals PDF Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN: 9789264122215
Category : Chemical industry
Languages : en
Pages :

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Book Description


OECD Series on Testing and Assessment Considerations for Assessing the Risks of Combined Exposure to Multiple Chemicals

OECD Series on Testing and Assessment Considerations for Assessing the Risks of Combined Exposure to Multiple Chemicals PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264952977
Category :
Languages : en
Pages : 119

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Book Description
The report outlines the technical aspects of the various approaches and methodologies available with respect to the assessment of risks from combined exposures to multiple chemicals. The document draws from approaches applied and experience gained in the regulatory context and will therefore be most relevant to the regulatory authorities addressing chemicals, the regulated community and other interested stakeholders.

Mixture Toxicity

Mixture Toxicity PDF Author: Cornelis A. M. van Gestel
Publisher: CRC Press
ISBN: 1439830096
Category : Medical
Languages : en
Pages : 312

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Book Description
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

Aquaculture Toxicology

Aquaculture Toxicology PDF Author: Frederick S.B. Kibenge
Publisher: Academic Press
ISBN: 0128213388
Category : Technology & Engineering
Languages : en
Pages : 250

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Book Description
Aquaculture Toxicology is an essential resource of practical information that covers mechanisms of toxicity and their responses to toxic agents, including aspects of uptake, metabolism and excretion of toxicants in fish, crustaceans and mollusks. This is a reliable, up-to-date, "all inclusive reference guide that provides an understanding of toxicology information for the aquaculture industry. Written by respected international experts recognized in specific areas of toxicology, this book covers toxins at the environmental, cellular and molecular levels. It identifies areas where more research is needed to generate more knowledge to support a sustainable aquaculture industry, including pharmaceutical pollutants and microplastics. - Presents clinical information for the three major aquatic food animals (fish, crustaceans and mollusks) - Discusses commonly used chemicals in aquaculture and their effects on aquatic animals and the environment - Provides the latest advancements in the field of toxicity to facilitate fisheries and aquaculture research

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure PDF Author: Aristidis M. Tsatsakis
Publisher: Elsevier
ISBN: 0323853587
Category : Medical
Languages : en
Pages : 686

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Book Description
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. - Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field - Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease - Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

Persistent Organic Pollutants in Aquatic Systems

Persistent Organic Pollutants in Aquatic Systems PDF Author: Tarek Othman Said
Publisher: Springer Nature
ISBN: 3031533410
Category : Organic water pollutants
Languages : en
Pages : 173

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Book Description
This book addressed an in-depth comprehension of the classifications and characterizations of POPs, which have become global issues due to bioaccumulation, persistency, and toxicity. It represents the milestones of the development of pesticide application, industry, and management. Banned SC-POPs have special investigations. It discusses air-sea exchange, ocean currents, phase distribution, speciation, adsorption, desorption, and degradation as the key processes that control POP's fate. The book explores several aspects of POP chemistry that have a direct influence on their biochemical and toxicological consequences. The book illustrates the dynamic equilibriums influencing the proportion of a POP's gaseous, liquid, and solid phases. The book discussed POP migration by referring to the grasshopper effect. It also explores the impacts of climate change on emissions and the fate of POPs through a global-scale multimedia fate model. Additionally, it displays the impact of potential global change scenarios on POP bioaccumulation patterns. The book is directed at giving a deep discussion of the method's QA/QC process for POP determination and has verified the accuracy and precision of the procedures. As a distinctive point, it discusses many aspects concerning the toxicity of POPs. It reports mechanisms describing the toxicity of POPs on immune systems, carcinogenesis, endocrine, neural, and reproductive systems. The book keeps an eye on a model describing the global distribution and toxicity of PAHs. Among the exclusive points in the book is the evaluation of the recent ecological status in Egypt relative to POPs through a time-scale overview and recent case studies. It provides thematic literature related to DDC research in Africa through the WoS and Scopus databases from 1949 to 2021. The book emphasizes models for predicting the annual contribution rate of POPs as a way to raise public awareness about POPs. The greatest challenge for the book is how to motivate the audience to be aware of these hazardous materials in marine ecosystems. Moreover, this book will be of great interest to academics, professionals, practitioners, post-graduate students, and undergraduates because it gives a clear overview of POPs in the marine environment. It also provides decision-makers with a realistic perspective of the environmental file, allowing them to address environmental issues and directing stockholders to safer locations for environmental activity. From a future perspective, the regulation of pervasive POPs, with special reference to recently evaluated harmful substances (PFASs), has faced significant challenges in the wake of pressure from regulators.

OECD Studies on Water Pharmaceutical Residues in Freshwater Hazards and Policy Responses

OECD Studies on Water Pharmaceutical Residues in Freshwater Hazards and Policy Responses PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264977414
Category :
Languages : en
Pages : 138

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Book Description
This report calls for a better understanding of the effects of pharmaceutical residues in the environment, greater international collaboration and accountability distribution, and policy actions to prevent and remedy emerging concerns. Laboratory and field tests show traces of oral contraceptives causing the feminisation of fish and amphibians, and residues of psychiatric drugs altering fish behaviour. Antimicrobial resistance, linked to the overuse of antibiotics, has rapidly escalated into a global health crisis.

OECD Series on Testing and Assessment Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests

OECD Series on Testing and Assessment Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264274758
Category :
Languages : en
Pages : 19

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Book Description
Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and include those assessing systemic toxicity as ...

Pharmaceutical Residues in Freshwater: Hazards and Policy Responses

Pharmaceutical Residues in Freshwater: Hazards and Policy Responses PDF Author: Organisation for Economic Co-Operation and Development (OECD)
Publisher: IWA Publishing
ISBN: 1789061814
Category : Science
Languages : en
Pages : 138

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Book Description
This report calls for a better understanding of the effects of pharmaceutical residues in the environment, greater international collaboration and accountability distribution, and policy actions to prevent and remedy emerging concerns. Laboratory and field tests show traces of oral contraceptives causing the feminisation of fish and amphibians, and residues of psychiatric drugs altering fish behaviour. Antimicrobial resistance, linked to the overuse of antibiotics, has rapidly escalated into a global health crisis. Unless adequate measures are taken to manage the risks, pharmaceutical residues will increasingly be released into the environment as ageing populations, advances in healthcare, and intensification of meat and fish production spur the demand for pharmaceuticals worldwide. The report outlines a collective, life‑cycle approach to managing pharmaceuticals in the environment. A policy mix of source‑directed, use‑orientated and end‑of‑pipe measures, involving several policy sectors, can help to improve health and protect the environment.

OECD Studies on Water Endocrine Disrupting Chemicals in Freshwater Monitoring and Regulating Water Quality

OECD Studies on Water Endocrine Disrupting Chemicals in Freshwater Monitoring and Regulating Water Quality PDF Author: OECD
Publisher: OECD Publishing
ISBN: 926434828X
Category :
Languages : en
Pages : 147

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Book Description
Endocrine disrupting chemicals (EDCs) are contaminants of emerging environmental and health concern that have been detected in freshwater, wastewater and drinking water. They interfere with the endocrine system in humans and wildlife, and produce adverse effects such as developmental, reproductive, neurological and immune effects.