Author: OECD
Publisher: OECD Publishing
ISBN: 9264264868
Category :
Languages : en
Pages : 30
Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 487: In Vitro Mammalian Cell Micronucleus Test
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264868
Category :
Languages : en
Pages : 30
Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
Publisher: OECD Publishing
ISBN: 9264264868
Category :
Languages : en
Pages : 30
Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
Test No. 487: In Vitro Mammalian Cell Micronucleus Test
Author: OECD
Publisher: OECD Publishing
ISBN: 9264224432
Category :
Languages : en
Pages : 26
Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
Publisher: OECD Publishing
ISBN: 9264224432
Category :
Languages : en
Pages : 26
Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects Test No. 487: In Vitro Mammalian Cell Micronucleus Test
Author: OECD
Publisher: OECD Publishing
ISBN: 9264091017
Category :
Languages : en
Pages : 24
Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
Publisher: OECD Publishing
ISBN: 9264091017
Category :
Languages : en
Pages : 24
Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
Test No. 474: Mammalian Erythrocyte Micronucleus Test
Author: OECD
Publisher: OECD Publishing
ISBN: 9264224297
Category :
Languages : en
Pages : 21
Book Description
The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.
Publisher: OECD Publishing
ISBN: 9264224297
Category :
Languages : en
Pages : 21
Book Description
The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.
Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes
Author: OECD
Publisher: OECD Publishing
ISBN: 9264243089
Category :
Languages : en
Pages : 18
Book Description
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...
Publisher: OECD Publishing
ISBN: 9264243089
Category :
Languages : en
Pages : 18
Book Description
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264906
Category :
Languages : en
Pages : 24
Book Description
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Publisher: OECD Publishing
ISBN: 9264264906
Category :
Languages : en
Pages : 24
Book Description
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro
Author: OECD
Publisher: OECD Publishing
ISBN: 926407144X
Category :
Languages : en
Pages : 7
Book Description
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
Publisher: OECD Publishing
ISBN: 926407144X
Category :
Languages : en
Pages : 7
Book Description
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay
Author: OECD
Publisher: OECD Publishing
ISBN: 9264366067
Category :
Languages : en
Pages : 37
Book Description
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Publisher: OECD Publishing
ISBN: 9264366067
Category :
Languages : en
Pages : 37
Book Description
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 473: In Vitro Mammalian Chromosomal Aberration Test
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264647
Category :
Languages : en
Pages : 22
Book Description
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Publisher: OECD Publishing
ISBN: 9264264647
Category :
Languages : en
Pages : 22
Book Description
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 432: In Vitro 3T3 NRU Phototoxicity Test
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071164
Category :
Languages : en
Pages : 20
Book Description
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ...
Publisher: OECD Publishing
ISBN: 9264071164
Category :
Languages : en
Pages : 20
Book Description
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ...