OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method PDF Download

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264071067
Category :
Languages : en
Pages : 8

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Book Description
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264071067
Category :
Languages : en
Pages : 8

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Book Description
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264071083
Category :
Languages : en
Pages : 8

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Book Description
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264242848
Category :
Languages : en
Pages : 28

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Book Description
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 404: Acute Dermal Irritation/Corrosion

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 404: Acute Dermal Irritation/Corrosion PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264242678
Category :
Languages : en
Pages : 8

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Book Description
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document for the Conduct of Skin Absorption Studies

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document for the Conduct of Skin Absorption Studies PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264078797
Category :
Languages : en
Pages : 31

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Book Description
This guidance document has been prepared to support technical aspects of the OECD skin absorption test guidelines. In particular is discusses the various aspects of in vivo vs. in vitro testing.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 411: Subchronic Dermal Toxicity: 90-day Study

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 411: Subchronic Dermal Toxicity: 90-day Study PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264070761
Category :
Languages : en
Pages : 9

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Book Description
This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance. It may be carried out after initial information obtained by acute testing. This method is composed of the main test and the limit ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264229825
Category :
Languages : en
Pages : 67

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Book Description
This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264242791
Category :
Languages : en
Pages : 13

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Book Description
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264353089
Category :
Languages : en
Pages : 28

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Book Description
Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity PDF Author: OECD
Publisher: OECD Publishing
ISBN: 9264070583
Category :
Languages : en
Pages : 13

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Book Description
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...