OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 404: Acute Dermal Irritation/Corrosion PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264242678
Category :
Languages : en
Pages : 8
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Book Description
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264242678
Category :
Languages : en
Pages : 8
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Book Description
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070621
Category :
Languages : en
Pages : 13
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Book Description
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. This Test Guideline recommends sequential testing strategies, which include the performance of validated and ...
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 8
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Book Description
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. This Test Guideline recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation. The albino rabbit is the preferable laboratory animal. The substance to be tested is applied in a single dose to a small area of skin (approximately 6cm2) of an experimental animal; untreated skin areas of the test animal serve as the control. The exposure period is 4 hours. Residual test substance should then be removed. The dose is 0.5ml (liquid) or 0.5g (solid) applied to the test site. The method consists of two tests: the initial test and the confirmatory test (used only if a corrosive effect is not observed in the initial test). All animals should be examined for signs of erythema and oedema during 14 days. The dermal irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. When responses persist to the end of the 14-day observation period, the test substance should be considered an irritant.
Author: OECD
Publisher: OECD Publishing
ISBN: 926418533X
Category :
Languages : en
Pages : 13
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Book Description
This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070648
Category :
Languages : en
Pages : 21
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Book Description
This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070583
Category :
Languages : en
Pages : 13
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Book Description
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264242848
Category :
Languages : en
Pages : 28
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Book Description
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264170200
Category :
Languages : en
Pages : 79
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Book Description
The OECD Guidelines for the Testing of Chemicals provide a unique tool for assessing the potential effects of chemicals on human health and the environment. Accepted internationally as the standard methods for safety testing, the OECD Guidelines for ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264242791
Category :
Languages : en
Pages : 13
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Book Description
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.
