Nordic Workshop on New Approach Methodologies (NAMs) PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Nordic Workshop on New Approach Methodologies (NAMs) PDF full book. Access full book title Nordic Workshop on New Approach Methodologies (NAMs) by Wojewodzic, Marcin W.. Download full books in PDF and EPUB format.
Author: Wojewodzic, Marcin W.
Publisher: Nordic Council of Ministers
ISBN: 928937313X
Category : Science
Languages : en
Pages : 86
Get Book Here
Book Description
Available online: https://pub.norden.org/temanord2022-526/ New Approach Methodologies (NAMs) are an emerging tool in toxicology for performing chemical risk assessment. NAMs reduce animal testing while increasing robustness, throughput and providing a mechanistic understanding of chemical modes-of-actions, in accordance with the Next Generation Risk Assessment principles. The workshop’s objective was to increase risk assessors’ understanding of the data produced by NAMs and their ability to use it for regulatory actions under REACH and CLP. It aimed to highlight the main challenges for NAMs, discuss possible advancements in using NAMs, and increase knowledge and competence within the relevant Nordic authorities. It also served to facilitate discussions about the obstacles to implementing NAMs in regulatory processes, and to identify strategies (including omics approaches) for increasing their use in read-across and grouping processes.
Author: Wojewodzic, Marcin W.
Publisher: Nordic Council of Ministers
ISBN: 928937313X
Category : Science
Languages : en
Pages : 86
Get Book Here
Book Description
Available online: https://pub.norden.org/temanord2022-526/ New Approach Methodologies (NAMs) are an emerging tool in toxicology for performing chemical risk assessment. NAMs reduce animal testing while increasing robustness, throughput and providing a mechanistic understanding of chemical modes-of-actions, in accordance with the Next Generation Risk Assessment principles. The workshop’s objective was to increase risk assessors’ understanding of the data produced by NAMs and their ability to use it for regulatory actions under REACH and CLP. It aimed to highlight the main challenges for NAMs, discuss possible advancements in using NAMs, and increase knowledge and competence within the relevant Nordic authorities. It also served to facilitate discussions about the obstacles to implementing NAMs in regulatory processes, and to identify strategies (including omics approaches) for increasing their use in read-across and grouping processes.
Author: Chantra Eskes
Publisher: Springer
ISBN: 3319338269
Category : Medical
Languages : en
Pages : 418
Get Book Here
Book Description
This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.
Author: Kathrin Herrmann
Publisher: BRILL
ISBN: 9004391193
Category : Philosophy
Languages : en
Pages : 749
Get Book Here
Book Description
Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.
Author: Anna Bal-Price
Publisher: Humana
ISBN: 9781493954803
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
Author: Michael E. Auer
Publisher: Springer Nature
ISBN: 3030672093
Category : Technology & Engineering
Languages : en
Pages : 572
Get Book Here
Book Description
This book contains papers in the fields of Interactive, Collaborative, and Blended Learning; Technology-Supported Learning; Education 4.0; Pedagogical and Psychological Issues. With growing calls for affordable and quality education worldwide, we are currently witnessing a significant transformation in the development of post-secondary education and pedagogical practices. Higher education is undergoing innovative transformations to respond to our urgent needs. The change is hastened by the global pandemic that is currently underway. The 9th International Conference on Interactive, Collaborative, and Blended Learning: Visions and Concepts for Education 4.0 was conducted in an online format at McMaster University, Canada, from 14th to 15th October 2020, to deliberate and share the innovations and strategies. This conference’s main objectives were to discuss guidelines and new concepts for engineering education in higher education institutions, including emerging technologies in learning; to debate new conference format in worldwide pandemic and post-pandemic conditions; and to discuss new technology-based tools and resources that drive the education in non-traditional ways such as Education 4.0. Since its beginning in 2007, this conference is devoted to new learning approaches with a focus on applications and experiences in the fields of interactive, collaborative, and blended learning and related new technologies. Currently, the ICBL conferences are forums to exchange recent trends, research findings, and disseminate practical experiences in collaborative and blended learning, and engineering pedagogy. The conference bridges the gap between ‘pure’ scientific research and the everyday work of educators. Interested readership includes policymakers, academics, educators, researchers in pedagogy and learning theory, school teachers, industry-centric educators, continuing education practitioners, etc.
Author: Gail Marshall
Publisher: Springer Science & Business Media
ISBN: 9780412814600
Category : Computers
Languages : en
Pages : 388
Get Book Here
Book Description
Deryn Watson CapBIT 97, Capacity Building for Information Technologies in Education in Developing Countries, from which this publication derives, was an invited IFIP working conference sponsored by Working Groups in secondary (WG 3. 1), elementary (WG 3. 5), and vocational and professional (WG 3. 4) education under the auspices ofIFIP Technical Committee for Education (TC3). The conference was held in Harare, Zimbabwe 25th - 29th August 1997. CapBIT '97 was the first time that the IFIP Technical Committee for Education had held a conference in a developing country. When the Computer Society of Zimbabwe offered to host the event, we determined that the location and conference topic reflect the importance of issues facing countries at all stages of developmen- especially Information Technologies (IT) development. Information Technologies have become, within a short time, one of the basic building blocks of modem industrial society. Understanding IT, and mastering basic skills and concepts of IT, are now regarded as part of the core education of all people around the world, alongside reading and writing. IT now permeates the business environment and underpins the success of modem corporations as well as providing government with cost-effective civil service systems. At the same time, the tools and technologies of IT are of value in the process of learning, and in the organisation and management of learning institutions.
Author: Jakob Vlietstra
Publisher: Springer Science & Business Media
ISBN: 1447102630
Category : Computers
Languages : en
Pages : 703
Get Book Here
Book Description
This Dictionary covers information and communication technology (ICT), including hardware and software; information networks, including the Internet and the World Wide Web; automatic control; and ICT-related computer-aided fields. The Dictionary also lists abbreviated names of relevant organizations, conferences, symposia and workshops. This reference is important for all practitioners and users in the areas mentioned above, and those who consult or write technical material. This Second Edition contains 10,000 new entries, for a total of 33,000.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264090932
Category :
Languages : en
Pages : 30
Get Book Here
Book Description
This Test Guideline describes procedures designed to assess bioaccumulation of chemicals in soil oligochaetes. The parameters which characterise the bioaccumulation of a substance include the bioaccumulation factor (BAF), the uptake rate constant ...
Author: Christoph A. Reinhardt
Publisher: John Wiley & Sons
ISBN: 3527616047
Category : Science
Languages : en
Pages : 200
Get Book Here
Book Description
Opinion leaders in science and politics examine findings and legislation in alternatives to animal testing! Refine, reduce, replace - These are the three demands that scientists have placed upon themselves in their search for alternatives to animal testing. Indeed much interdisciplinary research is being carried on today, and new fields have emerged, such as in-vitro toxicology. The three R's call for new scientific insights. Moreover, validation and acceptance strategies have to be adapted, a process of much ongoing interest and vital concern to the pharmaceutical and cosmetic industries. Researchers need to know exactly what has been achieved and accepted in alternatives to animal testing in science and politics. In this book they have the opportunity to benefit from the knowledge and expertise of leading researchers and influential representatives of national and international regulatory authorities.
Author: Lawrence W. Barnthouse
Publisher: CRC Press
ISBN: 1420053337
Category : Law
Languages : en
Pages : 377
Get Book Here
Book Description
Most ecological risk assessments consider the risk to individual organisms or organism-level attributes. From a management perspective, however, risks to population-level attributes and processes are often more relevant. Despite many published calls for population risk assessment and the abundance of available scientific research and technical tool
