NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens PDF Download
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Author: Martin Lorenz Stein
Publisher: Springer
ISBN: 331907914X
Category : Science
Languages : en
Pages : 84
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Book Description
Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.
Author: Martin Lorenz Stein
Publisher: Springer
ISBN: 331907914X
Category : Science
Languages : en
Pages : 84
Get Book Here
Book Description
Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.
Author: Tobias Kieser
Publisher:
ISBN: 9780708406236
Category : Bacterial genetics
Languages : en
Pages : 613
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Book Description
Author:
Publisher: Academic Press
ISBN: 9780128127940
Category : Science
Languages : en
Pages : 0
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Book Description
Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.
Author: P. Hlavica
Publisher: Springer Science & Business Media
ISBN: 9401131120
Category : Medical
Languages : en
Pages : 487
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Book Description
Author: Evi Stegmann
Publisher:
ISBN: 9783039369102
Category :
Languages : en
Pages : 362
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Book Description
Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes
Author: John Moffett
Publisher: Springer Science & Business Media
ISBN: 0387301720
Category : Medical
Languages : en
Pages : 379
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Book Description
N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. NAA is used in nonsurgical analyses of nerve cell dysfunction, and it is implicated in a disorder known as Canavan’s disease. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.
Author: Michael Karin
Publisher: Springer Science & Business Media
ISBN: 3642160174
Category : Medical
Languages : en
Pages : 273
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Book Description
Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation
Author: Gerry Wright
Publisher: Wiley
ISBN: 9781118376737
Category : Science
Languages : en
Pages : 384
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Book Description
Author: Silvano Simula
Publisher: Springer Science & Business Media
ISBN: 9783211832998
Category : Science
Languages : en
Pages : 404
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Book Description
The Workshop N* Physics and non-perturbative QeD was held at the Eu ropean Center for Theoretical Studies and Related Areas (ECT*) in Trento, Italy, during May 18-29, 1998. Previous workshops of the series on N* Physics took place at the Florida State University (1994), at CEBAF (1995), at the Institute for Nuclear Theory in Seattle (1996) and at the George Washington University (1997). The Workshop was devoted to a summary of recent experimental and the oretical research on N* phsyics and special emphasis was given to the infor mation that photo-and electro-production of nucleon resonances can provide on the non-perturbative regime of Quantum Chromodynamics. The idea was to stimulate discussions among experimentalists and theoreticians in order to pursue the interpretation of the huge amount of forthcoming data from several laboratories in the world. It was therefore decided to have both experimental and theoretical lectures on the main topics, like ,among the others, single and double pion production, TJ-and K-meson production, the GDH sum rule, the spin of the proton, etc. Thanks to the unusual two-week extension of the Work shop, the allotted time for the lectures was extended up to one hour in order to allow the invited lecturers to give a detailed presentation of their topics. Fi nally, various short contributions were selected to sharpen the discussion about selected items.
Author: Elliott Burnell
Publisher: Springer Science & Business Media
ISBN: 9781402013430
Category : Science
Languages : en
Pages : 494
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Book Description
NMR of Ordered Liquids gives a unique overview of the scope and limitations of the NMR of oriented liquids, based on contributions from acknowledged experts in the field. The book consists of four sections: -detailed general introduction which covers the basic principles and sophisticated experimental techniques; -wide variety of applications ranging from NMR studies of small atoms and molecules in anisotropic liquids to the utilization of residual dipolar couplings for structure determination of biological molecules; -summary of the sophisticated theoretical treatments, computer simulations, and phenomenological models for anisotropic intermolecular interactions that are widely used in the analysis of experimental results; -overview of the dynamical aspects and relaxation processes relevant for orientationally ordered molecules.
