New Pathways for Functionalization of Phosphorus Ligands PDF Download
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Author: Anna Ordyszewska
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Anna Ordyszewska
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Paul C. J. Kamer
Publisher: John Wiley & Sons
ISBN: 1118299701
Category : Technology & Engineering
Languages : en
Pages : 673
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Book Description
Over the last 60 years the increasing knowledge of transition metal chemistry has resulted in an enormous advance of homogeneous catalysis as an essential tool in both academic and industrial fields. Remarkably, phosphorus(III) donor ligands have played an important role in several of the acknowledged catalytic reactions. The positive effects of phosphine ligands in transition metal homogeneous catalysis have contributed largely to the evolution of the field into an indispensable tool in organic synthesis and the industrial production of chemicals. This book aims to address the design and synthesis of a comprehensive compilation of P(III) ligands for homogeneous catalysis. It not only focuses on the well-known traditional ligands that have been explored by catalysis researchers, but also includes promising ligand types that have traditionally been ignored mainly because of their challenging synthesis. Topics covered include ligand effects in homogeneous catalysis and rational catalyst design, P-stereogenic ligands, calixarenes, supramolecular approaches, solid phase synthesis, biological approaches, and solubility and separation. Ligand families covered in this book include phosphine, diphosphine, phosphite, diphosphite, phosphoramidite, phosphonite, phosphinite, phosphole, phosphinine, phosphinidenene, phosphaalkenes, phosphaalkynes, P-chiral ligands, and cage ligands. Each ligand class is accompanied by detailed and reliable synthetic procedures. Often the rate limiting step in the application of ligands in catalysis is the synthesis of the ligands themselves, which can often be very challenging and time consuming. This book will provide helpful advice as to the accessibility of ligands as well as their synthesis, thereby allowing researchers to make a more informed choice. Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis is an essential overview of this important class of catalysts for academic and industrial researchers working in catalyst development, organometallic and synthetic chemistry.
Author: Jurjen Meeuwissen
Publisher:
ISBN:
Category :
Languages : en
Pages : 127
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Author: Jean-Pierre Majoral
Publisher: Springer
ISBN: 3540457313
Category : Science
Languages : en
Pages : 250
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Book Description
Undoubtedly the chemistry of phosphorus appears more and more attractive in the sense that phosphorus presents an extraordinary versatile behaviour that allows the synthesis of a large number of different phosphorus reagents usable for applications in different fields, from biology to material science without f- getting key applications in catalysis. The full maturity of this topic of research can be explained by all the acquired knowledge over these twenty last years. Organic and inorganic chemistries of P , P and P species have been the s- in ]V v ject of thousands of publications while the chemistry of low coordinated ph- phorus derivatives experienced its hour of glory from the 1970s to the early 1990s. In parallel, interactions between phosphorus compounds and transition metals afforded many complexes, a lot of which present fascinating properties as catalysts. The interest in all these themes really is not decreasing, indeed some fas- nating areas of research are emerging or are the subject of many investigations: the medicinal chemistry of bisphosphonates, the role of phosphorus in biology, phosphorus ligands in radiopharmaceutical chemistry, phosphorus in material science, new polymers and dendrimers incorporating phosphorus, and as- metric catalysis to name but a few. Indeed researchers, benefitting from their background in basic phosphorus chemistry are developing many new fields of research.
Author: Qian Dai
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Junliang Zhang
Publisher: Elsevier
ISBN: 0323852262
Category : Science
Languages : en
Pages : 322
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Book Description
Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis summarizes the most significant progress in the field of chiral phosphine ligand chemistry and a broad range of earth-abundant transition metal/chiral phosphine ligand-catalyzed enantioselective transformations. The book provides an authoritative and in-depth understanding of important topics about asymmetric catalysis based on earth-abundant transition metals/chiral phosphine ligands, making it ideal for organic chemistry researchers working in the field of asymmetric catalysis, synthetic methodologies and total synthesis.The development of new chiral phosphine ligands to achieve precise stereo control in many earth-abundant transition metal-catalyzed reactions is a very important field in organic synthesis, materials science and medicinal chemistry. The asymmetric synthesis promoted by transition metal/chiral phosphine ligands provides one of the most ideal ways to produce valuable optically active chemicals. - Includes a discussion of state-of-the-art asymmetric organic reactions mediated by earth-abundant transition metals and chiral phosphine ligands - Features the progress and the prospect of chiral phosphine ligands in asymmetric transition metal catalysis - Covers the asymmetric reactivity modes of earth-abundant transition metals and phosphine ligands
Author: Yaping Zou
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Paul Kamer
Publisher: John Wiley & Sons
ISBN: 9781119943990
Category : Catalysis
Languages : en
Pages :
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Book Description
Over the last 60 years the increasing knowledge of transition metal chemistry has resulted in an enormous advance of homogeneous catalysis as an essential tool in both academic and industrial fields. Remarkably, phosphorus(III) donor ligands have played an important role in several of the acknowledged catalytic reactions. The positive effects of phosphine ligands in transition metal homogeneous catalysis have contributed largely to the evolution of the field into an indispensable tool in organic synthesis and the industrial production of chemicals. This book aims to address the design and synthesis of a comprehensive compilation of P(III) ligands for homogeneous catalysis. It not only focuses on the well-known traditional ligands that have been explored by catalysis researchers, but also includes promising ligand types that have traditionally been ignored mainly because of their challenging synthesis. Topics covered include ligand effects in homogeneous catalysis and rational catalyst design, P-stereogenic ligands, calixarenes, supramolecular approaches, solid phase synthesis, biological approaches, and solubility and separation. Ligand families covered in this book include phosphine, diphosphine, phosphite, diphosphite, phosphoramidite, phosphonite, phosphinite, phosphole, phosphinine, phosphinidenene, phosphaalkenes, phosphaalkynes, P-chiral ligands, and cage ligands. Each ligand class is accompanied by detailed and reliable synthetic procedures. Often the rate limiting step in the application of ligands in catalysis is the synthesis of the ligands themselves, which can often be very challenging and time consuming. This book will provide helpful advice as to the accessibility of ligands as well as their synthesis, thereby allowing researchers to make a more informed choice. "Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis" is an essential overview of this important class of catalysts for academic and industrial researchers working in catalyst development, organometallic and synthetic chemistry.
Author: Yu-Ming Chie
Publisher:
ISBN:
Category : Hydroformylation
Languages : en
Pages : 64
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Book Description
Tetraphosphorous ligands with enhanced chelating ability through multiple chelating modes and increased local phosphorus concentration can provide great regioselectivity in Rh/Ligand hydroformylation system. Here we report the synthesis of a series of pyrrole-based tetraphosphorus ligands were synthesized with introducing different functional groups into 3, 3', 5, 5'-positions of the biphenyl, and their applications to the hydroformylation of internal olefins, 1, 5-hexadiene, styrene and its derivatives, and alkyl acrylates. Internal olefins are cheaper and more readily available feedstock than terminal olefins, the development of highly selective and active isomerization-hydroformylation catalysts for internal olefins is of great importance from economic and energy points of view. In particular, the alkyl-substituted tetraphosphorous ligands gave the best results (for 2-octene, n: i up to 207, for 2-hexene, n: i up to 362). Double hydroformylation of 1, n-diolefins is a convenient method to produce dialdehydes. The hydroformylation of 1, 5- hexadiene can be achieved with essentially high regioselectivity (linear selectivity is up to 98%). Styrene and its derivatives prefer the branched aldehydes under the hydro-formylation conditions. However, the linear aldehydes can also be widely used for the production of detergents and plasticizers and important intermediates. Our studies on the hydroformylation of styrene and its derivatives achieved unprecedented high linear selectivity (l/b up to 22 for styrene). Hydroformylation of alkyl acrylate produces 1, 3- and1, 4-bifunctional compounds, which can be further converted into synthetically useful intermediates. Alkyl acrylates have been hydroformylated to the linear aldehydes with high regioselectivity (linear/branch> 99/1) and extraordinarily high average turnover frequencies (up to 5400 h 1) by using a rhodium complex with a tetraphosphorus ligand. The result is in sharp contrast to the most of other processes that favor production of the branched aldehyde (typically> 95% branched for most Rh-catalyzed reaction systems).
Author: Bonan Cao
Publisher:
ISBN:
Category : Chirality
Languages : en
Pages : 130
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Book Description
Transition-metal-catalyzed reactions have become powerful tools in the production of pharmaceuticals and fine chemicals. In the past decades, asymmetric catalysis, especially chiral rhodium catalysts, hold an increasing role of efficiently building up chirality. In this dissertation, we will focus on the development of several rhodium phosphorus catalysts and their applications in hydroformylation and asymmetric hydrogenation reactions. Chapter I outlined the development of a new family of sterrically rigid hybrid phosphine-phosphoramidite ligands. The new catalyst system shows excellent compatibility versus styrene, vinyl acetate, allyl cyanide and their derivatives. The relationship between the enantioselectivity and the substituent on ligands is investigated by systematic variation on the ligand structures. In chapter II, further application of phosphine-phosphoramidite ligands in asymmetric hydroformylation of N-allylamides and N-allylsulfonamides provides a new approach to chiral [beta]2-amino aldehydes, acids, and alcohols for pharmaceutical and synthetic chemistry. Up to 99% ee and 9700 turnovers stands as the best result achieved in this type of hydroformylation reaction. Chapter III focuses on the synthesis of a series of aryl substituted dihydropyrroles via this hydroformylation. The significant improvement in reactivity and chemoselectivity suggests a potential application in building large heterocycles in an atom efficient fashion. In chapter IV, I report a successful monodentate phosphoramidite ligand for the catalytic asymmetric hydrogenation of dehydroamino esters. The easy modulared structure allowed us to further expand the scope of the ligand.
