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Author: Judith Fraussen
Publisher: Frontiers Media SA
ISBN: 2889745651
Category : Medical
Languages : en
Pages : 232
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Book Description
Author: Judith Fraussen
Publisher: Frontiers Media SA
ISBN: 2889745651
Category : Medical
Languages : en
Pages : 232
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Book Description
Author: Tasuku Honjo
Publisher: Academic Press
ISBN: 9780123979339
Category : Science
Languages : en
Pages : 0
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Book Description
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Author: Jérôme Paggetti
Publisher: Frontiers Media SA
ISBN: 2889742415
Category : Medical
Languages : en
Pages : 164
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Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Rui Li
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Important antibody-independent pathogenic roles of B cells are emerging in autoimmune diseases including MS. The contrasting results of different treatments targeting B cells in patients (in spite of predictions of therapeutic benefit from animal models) call for a better understanding of the multiple roles that distinct human B cell subsets likely play in this illness. Cytokines expressed by B cells can be used as potential markers to define functionally distinct subsets. In spite of work carried out in mice, there remain substantial gaps in our knowledge of human cytokine-defined B cell subsets. The aim of my thesis is to better understand human cytokine-defined B cell subsets in both health and in MS, including their surface phenotype, distinct functions and the mechanisms (both external and internal) that regulate them. In the first part (Chapter 2) of my manuscript-based thesis, I identified a novel GM-CSF+ TNF[alpha]high IL-6high IL-10- effector B cell (Beff) subset that is abnormally increased, and more readily induced, in the peripheral blood of MS patients. These Beff cells strongly enhanced macrophage pro-inflammatory cytokine production through a GM-CSF-dependent mechanism. STAT5 and STAT6 were found to be important regulators of the balance between the Beff and Breg B cell subsets. Studies in patients with MS demonstrated that removal of total B cells using anti-CD20 therapy (which is very effective in limiting new MS activity) resulted in decreased myeloid cell pro-inflammatory responses. When B cells reconstituted in these patients, myeloid cells remained less inflammatory, in keeping with the lesser inflammatory profile of the reconstituting B cells. In chapter 3, I wished to investigate the impact of distinct B cell cytokine-defined subsets on T cell responses. To date, the study of B cell:T cell interactions in humans has been limited in part due to the lack of antigen specific systems to assess these interactions. I was able to establish a novel antigen-specific B-T co-culture system and used it to demonstrate that Beff cells can significantly enhance antigen-specific T cells responses to pathogens in an MHC-II restricted, CD80/CD86 and IL-6 dependent fashion. In chapter 4, I examined more closely the impact of human IL-10 expressing Breg cells on myeloid responses. I found that pro-inflammatory myeloid cell cytokine (IL-6, IL-12, TNF[alpha]) responses are significantly inhibited in co-culture with CpG-induced human Breg, an effect that was partially IL-10 dependent. CpG induced Bregs also inhibited expression of myeloid cell MHC-II and the co-stimulatory molecule CD86. Interestingly, atacicept (a TACI-Ig fusion protein) appeared to limit the induction of IL-10 expressing Bregs, providing a potential explanation for the paradoxical increase in MS disease activity seen with atacicept treatment. Together, the studies of my thesis enhance our understanding of human cytokine-defined, functionally distinct B cell subsets, both in healthy individuals and in MS patients. My results provide novel insights into the therapeutic mode of action of B cell depleting therapies in autoimmune disease, and the rational for selective targeting of distinct B cell subsets for future therapeutic approaches to both infectious and immune-mediated disease. " --
Author: Jérôme Paggetti
Publisher: Frontiers Media SA
ISBN: 2889742075
Category : Medical
Languages : en
Pages : 127
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Book Description
Author: Changjun Yin
Publisher: Frontiers Media SA
ISBN: 2889451801
Category :
Languages : en
Pages : 237
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Book Description
The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.
Author: Zhenming Xu
Publisher: Frontiers Media SA
ISBN: 2889719588
Category : Medical
Languages : en
Pages : 213
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Author: Yiwei Chu
Publisher: Frontiers Media SA
ISBN: 288976155X
Category : Medical
Languages : en
Pages : 128
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Book Description
Author: Jérôme Paggetti
Publisher: Frontiers Media SA
ISBN: 2889742067
Category : Medical
Languages : en
Pages : 191
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Book Description
Topic Editor MS received funding from Bayer AG.
