New Approaches to Improve Extracorporeal Photopheresis for the Treatment of Graft-versus-host Disease PDF Download
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 218
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Book Description
Graft-versus-host disease (GvHD) is a severe complication occurring after hematopoietic stem cell transplantation (HSCT). It is caused by alloreactive T cells contained in the graft, and associated with severe morbidity and mortality. Glucocorticoids (GC) are the gold standard for first-line treatment of GvHD but once patients become steroid-refractory, they need to be treated with second-line therapies such as extracorporeal photopheresis (ECP). ECP is an immunomodulatory therapy currently used in the clinic for treating patients suffering acute GvHD (aGvHD) or chronic GvHD (cGvHD). During...
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 218
Get Book Here
Book Description
Graft-versus-host disease (GvHD) is a severe complication occurring after hematopoietic stem cell transplantation (HSCT). It is caused by alloreactive T cells contained in the graft, and associated with severe morbidity and mortality. Glucocorticoids (GC) are the gold standard for first-line treatment of GvHD but once patients become steroid-refractory, they need to be treated with second-line therapies such as extracorporeal photopheresis (ECP). ECP is an immunomodulatory therapy currently used in the clinic for treating patients suffering acute GvHD (aGvHD) or chronic GvHD (cGvHD). During...
Author: Michelle Kenyon
Publisher: Springer
ISBN: 3319500260
Category : Medical
Languages : en
Pages : 318
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Book Description
This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.
Author: Hildegard T. Greinix
Publisher: Walter de Gruyter
ISBN: 3110276135
Category : Medical
Languages : en
Pages : 228
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Book Description
Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient’s blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.
Author: Georgia B. Vogelsang
Publisher: Cambridge University Press
ISBN: 1139478893
Category : Medical
Languages : en
Pages : 427
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Book Description
Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.
Author: Nicolaus Kröger
Publisher:
ISBN: 9781013273674
Category : Medical
Languages : en
Pages : 688
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Book Description
This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author: Nathaniel Edward Bennett Saidu
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Jonathan A. Cotliar
Publisher: Springer
ISBN: 3319469525
Category : Medical
Languages : en
Pages : 170
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Book Description
This atlas provides trainees and practicing physicians a visual toolkit to help recognize and manage this difficult condition appropriately. This text highlights the clinical variability of GVHD, and arms readers with the diagnostic clues to categorize patients according to the current grading/staging guidelines. Furthermore, this atlas offers evidence-based diagnostic and treatment algorithms for physicians to use while at patients' bedsides.
Author: Francis P. Gasparro
Publisher: R. G. Landes
ISBN:
Category : Medical
Languages : en
Pages : 158
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Book Description
Author: Wendy Lynne Hurwitz
Publisher:
ISBN:
Category : Bone marrow
Languages : en
Pages : 108
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Book Description
Author: Mammen Chandy
Publisher: Springer
ISBN: 9783030363574
Category : Medical
Languages : en
Pages : 0
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Book Description
Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants. There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals. This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering various facets of hematopoietic stem cell transplants with latest insights about the technique and basic science behind it . The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation.The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies , which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients.
