Environmental Neurotoxicology

Environmental Neurotoxicology PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309045312
Category : Science
Languages : en
Pages : 167

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Book Description
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.

Environmental Neurotoxicology

Environmental Neurotoxicology PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309045312
Category : Science
Languages : en
Pages : 167

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Book Description
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.

Nervous System Toxicology

Nervous System Toxicology PDF Author: Clifford L. Mitchell
Publisher: Raven Press (ID)
ISBN:
Category : Medical
Languages : en
Pages : 400

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Book Description


Recent Advances in Nervous System Toxicology

Recent Advances in Nervous System Toxicology PDF Author: Corrado L. Galli
Publisher: Springer Science & Business Media
ISBN: 1461308879
Category : Medical
Languages : en
Pages : 384

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Book Description
This volume addresses some facets of the adverse actions of chemical agents on the central and peripheral nervous systems in developing and mature states. Some of the effects of these chemicals are short-lasting and rapidly reversible; others, especially those that cause structural damage to the nervous system, may result in permanent damage to the organism. The nervous system has several levels of vulnerability to toxic substances. Some substances perturb ion channels or synaptic mechanisms required for the orderly transfer of electrochemical information within the nervous system. Others disrupt sites required for the maintenance of cellular integrity, and these variably result in degenerative responses of neurons and myelinating cells. Further sites of vulnerability include the delicate neural vasculature and neurohumeral mechanisms responsible for physiological homeostasis. The science of neurotoxicology inevitably is a multidisciplinary endeavor, with contributions from biochemistry, physiology, morphology and behavior, to name a few. The challenge is to apply appropriate techniques to investigate neurotoxic phenomena. The first logical step in this analysis is to determine from the point of view of the nervous system the nature of the exposure. Is the chemical a single or multiple entity; is it metabolized; how does it gain access to neural tissue? Once these factors are understood, changes induced by the exposure can be described at various levels from the biochemical to the behavioral.

Drinking Water and Health,

Drinking Water and Health, PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309036879
Category : Nature
Languages : en
Pages : 476

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Book Description
The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.

Behavioral Measures of Neurotoxicity

Behavioral Measures of Neurotoxicity PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309040477
Category : Science
Languages : en
Pages : 449

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Book Description
Exposure to toxic chemicalsâ€"in the workplace and at homeâ€"is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs. This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed.

Pharmacological Effects of Ethanol on the Nervous System

Pharmacological Effects of Ethanol on the Nervous System PDF Author: Richard A. Deitrich
Publisher: CRC Press
ISBN: 9780849383892
Category : Medical
Languages : en
Pages : 482

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Book Description
This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on that system. The behaviors themselves are discussed in later chapters. Some older theories of the effects of ethanol such as the membrane fluidization hypothesis are evaluated in light of new and updated information. Fetal Alcohol Syndrome (FAS) as well as the structural damage in the brain by long term ethanol exposure are also discussed.

Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives, Volume III

Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives, Volume III PDF Author: Stanley Berent
Publisher: Taylor & Francis
ISBN: 1136874380
Category : Medical
Languages : en
Pages : 658

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Book Description
This is the final volume in a three-volume work that has addressed the scientific methodologies relevant to clinical neurobehavioral toxicology. Volume III attends to what is known about industrial and environmental chemicals, medicines, and substances of abuse and how these agents affect the central nervous system. How to determine that a specified substance has caused harm is emphasized by way of case examples and discussion. Illnesses and behavioral variations that compete with toxicant-induced explanations for findings in a given case, as well as the various controversies that can arise around issues of diagnosis and causal determination, are treated comprehensively in this volume.

Clinical Neurotoxicology

Clinical Neurotoxicology PDF Author: Michael R. Dobbs
Publisher: Elsevier Health Sciences
ISBN: 0323052606
Category : Medical
Languages : en
Pages : 729

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Book Description
Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You'll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors-such as heavy metals and pesticides-and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. And, Expert Consult functionality allows you to access the full text of the book online, from any Internet connection. Provides a complete listing of neurotoxic agents-from manufactured to environmental-so you get comprehensive, clinical coverage. Covers how toxins manifest themselves according to age and co-morbidity so that you can address the needs of all your patients. Offers broad and in-depth coverage of toxins from all over the world through contributions by leading authorities and up-and-coming clinical neurotoxicologists. Features discussion of controversial and unusual topics such as Gulf War Syndrome, Parkinson's Disease, motor neuron disease, as well as other issues that are still in question. Includes access to www.expertconsult.com, a companion website where you can quickly search the complete contents of the book. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.

Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives, Volume II

Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives, Volume II PDF Author: James W. Albers
Publisher: Taylor & Francis
ISBN: 1135421064
Category : Psychology
Languages : en
Pages : 514

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Book Description
This book, the second of three volumes, concentrates on peripheral nervous system disorders. Examining the effects of neurotoxicants on nerve, muscle and the neuromuscular junction, it builds on the scientific principles outlined in volume 1 by looking at the application of the methods discussed, particularly in terms of the evaluation and diagnosis of individual patients and the related process of establishing causation. Neurobehavorial Toxicology, Volume 2 will be of interest to practicing neurologists and neuropsychologists, as well as to occupational medicine physicians and medical toxicologists.

Fundamental Neuropathology for Pathologists and Toxicologists

Fundamental Neuropathology for Pathologists and Toxicologists PDF Author: Brad Bolon
Publisher: John Wiley & Sons
ISBN: 1118002237
Category : Science
Languages : en
Pages : 661

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Book Description
This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).