Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope

Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope PDF Author: Syed Shams ul Hassan
Publisher: Frontiers Media SA
ISBN: 2832557562
Category : Science
Languages : en
Pages : 409

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Book Description
From decades, natural products have been a significant source of health remedies. The use of nature-oriented, bioactive substances in the development of new drugs and traditional medicine is still the priority of the pharmaceuticals. More than 80% to 85% of people throughout the world rely on traditional medicine (TM), as their primary form of healthcare. The easily available TM, mostly herbal products prepared from whole herbs or their extracts, have a significant economic role in many Asian, African, American, and European nations. Therefore, it has become urgent to increase the TM and its constituents' quality, safety, and effectiveness. This can only be accomplished by scientifically validating the lead compounds in TM's chemical foundation and their mode of action. Thanks to the advanced technologies and equipment’s which now has made it easy to create the scaffolds of natural products in the lab, saving a great deal of time as compared to isolating the natural product from its source.

Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope

Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope PDF Author: Syed Shams ul Hassan
Publisher: Frontiers Media SA
ISBN: 2832557562
Category : Science
Languages : en
Pages : 409

Get Book Here

Book Description
From decades, natural products have been a significant source of health remedies. The use of nature-oriented, bioactive substances in the development of new drugs and traditional medicine is still the priority of the pharmaceuticals. More than 80% to 85% of people throughout the world rely on traditional medicine (TM), as their primary form of healthcare. The easily available TM, mostly herbal products prepared from whole herbs or their extracts, have a significant economic role in many Asian, African, American, and European nations. Therefore, it has become urgent to increase the TM and its constituents' quality, safety, and effectiveness. This can only be accomplished by scientifically validating the lead compounds in TM's chemical foundation and their mode of action. Thanks to the advanced technologies and equipment’s which now has made it easy to create the scaffolds of natural products in the lab, saving a great deal of time as compared to isolating the natural product from its source.

Indole Ring Synthesis

Indole Ring Synthesis PDF Author: Gordon W. Gribble
Publisher: John Wiley & Sons
ISBN: 0470512180
Category : Science
Languages : en
Pages : 704

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Book Description
Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.

Natural Products Targeting Clinically Relevant Enzymes

Natural Products Targeting Clinically Relevant Enzymes PDF Author: Paula B. Andrade
Publisher: John Wiley & Sons
ISBN: 3527342052
Category : Medical
Languages : en
Pages : 348

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Book Description
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

WHO Global Report on Traditional and Complementary Medicine 2019

WHO Global Report on Traditional and Complementary Medicine 2019 PDF Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241515430
Category : Business & Economics
Languages : en
Pages : 228

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Book Description
This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).

Plant-derived Natural Products

Plant-derived Natural Products PDF Author: Anne E. Osbourn
Publisher: Springer Science & Business Media
ISBN: 0387854983
Category : Science
Languages : en
Pages : 588

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Book Description
Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Drug Discovery from Natural Products

Drug Discovery from Natural Products PDF Author: Olga Genilloud
Publisher: Royal Society of Chemistry
ISBN: 1849733619
Category : Medical
Languages : en
Pages : 435

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Book Description
An integrated review of the most recent trends in natural products, drug discovery, and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

Natural Products in Clinical Trials

Natural Products in Clinical Trials PDF Author: Atta-ur- Rahman
Publisher: Bentham Science Publishers
ISBN: 1681082136
Category : Medical
Languages : en
Pages : 253

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Book Description
Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Macrocycles in Drug Discovery

Macrocycles in Drug Discovery PDF Author: Jeremy I Levin
Publisher: Royal Society of Chemistry
ISBN: 1849737010
Category : Medical
Languages : en
Pages : 526

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Book Description
This series provides a comprehensive resource for postgraduate students and for scientists in academia or industry wanting to learn topics outside their own areas of expertise.

The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases PDF Author: M. Mohamed Essa
Publisher: Springer
ISBN: 3319283839
Category : Medical
Languages : en
Pages : 497

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Book Description
Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Principles of Regenerative Medicine

Principles of Regenerative Medicine PDF Author: Anthony Atala
Publisher: Academic Press
ISBN: 0123814235
Category : Science
Languages : en
Pages : 1203

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Book Description
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. - Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology - The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine - New discoveries from leading researchers on restoration of diseased tissues and organs