Molecularly Targeted Therapy for Childhood Cancer PDF Download
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Author: Peter J. Houghton
Publisher: Springer Science & Business Media
ISBN: 038769062X
Category : Medical
Languages : en
Pages : 548
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Book Description
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Author: Peter J. Houghton
Publisher: Springer Science & Business Media
ISBN: 038769062X
Category : Medical
Languages : en
Pages : 548
Get Book
Book Description
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Author: Peter J. Houghton
Publisher: Springer
ISBN: 9780387690605
Category : Medical
Languages : en
Pages : 536
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Book Description
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Author: Yujin Hoshida
Publisher: Springer
ISBN: 3030215407
Category : Medical
Languages : en
Pages : 366
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Book Description
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Author: National Academies of Sciences Engineering and Medicine
Publisher:
ISBN: 9780309683494
Category :
Languages : en
Pages :
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Book Description
Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
Author: Philip A Pizzo, MD
Publisher: Lippincott Raven
ISBN: 9780781726580
Category : Cancer in children
Languages : en
Pages : 0
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Book Description
The definitive reference on pediatric oncology is now in its thoroughly revised, updated Fourth Edition. A multidisciplinary group of the world's foremost specialists presents state-of-the-art information and guidelines on every aspect of pediatric cancer--from molecular biology to diagnosis, multimodal therapy, and supportive care.This edition features greater integration of the biologic and genetic factors affecting diagnosis and treatment. New chapters discuss incidence and trends in childhood cancer, evolving molecular and targeted therapies, and training strategies to develop humanistic skills in the pediatric hematologist-oncologist. Also included are up-to-date listings of support resources for children with cancer and for their families and physicians. A Brandon-Hill recommended title.
Author: Antonio Russo
Publisher: Humana Press
ISBN: 1493920472
Category : Medical
Languages : en
Pages : 269
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Book Description
This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.
Author: Manfred Dietel
Publisher: Springer
ISBN: 9783642432439
Category : Medical
Languages : en
Pages : 0
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Book Description
From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
Author:
Publisher: Elsevier
ISBN: 0443192812
Category : Medical
Languages : en
Pages : 332
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Book Description
Advances in Cancer Research, Volume 160, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research, with this updated edition covering PFKP: More Than Phosphofructokinase, Setting sail: maneuvering SHP2 activity and its effects in cancer, Mechanical factors driving cancer progression, Microsomal Glutathione Transferase 1 in Cancer and the Regulation of Ferroptosis, Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance, Head and Neck Cancer Treatment in the Era of Molecular Medicine, Applications of Tissue-Specific and Cancer-Selective Gene Promoters for Cancer Diagnosis and Therapy, and more. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Author: Margie Patlak
Publisher:
ISBN: 9780309368575
Category : Medical
Languages : en
Pages : 0
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Book Description
"One of the challenges in treating cancer is the disease's complexity and variation among patients. Cancer manifests differently in each patient, so treatments that are effective in one patient may not be effective in another. As cancer care becomes more personalized, subpopulations of individuals will be given preventive or therapeutic interventions based on their susceptibility to a particular disease or their predicted response to a specific treatment. However, before the use of personalized cancer care can reach its full potential, the health care system must resolve a number of technological, regulatory, and reimbursement issues. To explore these policy challenges, the National Cancer Policy Forum held the workshop Policy Issues in the Development of Personalized Medicine in Oncology in June 2009. Experts provided presentations on the current state of personalized medicine technology, as well as issues in the validation of, regulation of, and reimbursement for the predictive tests that underpin personalized medicine. Participants discussed the obstacles and possible solutions to further developing and using personalized medicine technologies. This document summarizes the workshop"--
Author: Ajay Vora
Publisher: Springer
ISBN: 3319397087
Category : Medical
Languages : en
Pages : 342
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Book Description
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
