Molecular Mechanisms and Models of Aging, Volume 1119 PDF Download
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Author: Efstathios S. Gonos
Publisher: Wiley-Blackwell
ISBN: 9781573316866
Category : Science
Languages : en
Pages : 0
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Book Description
Aging is an inevitable consequence of life for nearly all organisms. It mostly reflects the outcome of complicated interactions between genetic factors along with the accumulation of a variety of deleterious stochastic changes over time. Thus, aging is an adaptive process, not caused by a single factor or process, but it is rather a multifactorial procedure modulated by the interplay among genetic and environmental factors. In the coming years, human aging will be one of the biggest challenges faced by industrialized countries as the average life expectancy is continuously increasing. This volume gathers together contributions from the top scientists and covers the whole range of modern research on aging. More specifically, the following topics are included: replicative senescence, telomeres and telomerase, cancer and aging, DNA repair, free radicals and oxidative stress, proteolysis and proteins maintenance, Immunity, neurodegeneration, model organisms, intervention as well as evolutional and epidemiological aspects. Overall, increasing our understanding of the aging process at the molecular level and applying available interventions will help to protect and preserve healthy aging. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member
Author: Efstathios S. Gonos
Publisher: Wiley-Blackwell
ISBN: 9781573316866
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
Aging is an inevitable consequence of life for nearly all organisms. It mostly reflects the outcome of complicated interactions between genetic factors along with the accumulation of a variety of deleterious stochastic changes over time. Thus, aging is an adaptive process, not caused by a single factor or process, but it is rather a multifactorial procedure modulated by the interplay among genetic and environmental factors. In the coming years, human aging will be one of the biggest challenges faced by industrialized countries as the average life expectancy is continuously increasing. This volume gathers together contributions from the top scientists and covers the whole range of modern research on aging. More specifically, the following topics are included: replicative senescence, telomeres and telomerase, cancer and aging, DNA repair, free radicals and oxidative stress, proteolysis and proteins maintenance, Immunity, neurodegeneration, model organisms, intervention as well as evolutional and epidemiological aspects. Overall, increasing our understanding of the aging process at the molecular level and applying available interventions will help to protect and preserve healthy aging. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member
Author: M. Eric Gershwin
Publisher: Wiley-Blackwell
ISBN: 9781573317092
Category : Medical
Languages : en
Pages : 752
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Book Description
The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results. This is the second volume of a series of four on autoimmunity, and findings related to particular organs, organ systems, and diseases are presented. The focus in Part B is on genetics and advances in treatment. Part A presents new principles in autoimmunity and new diagnostic tools. See Parts C and D for clinical venues in autoimmunity. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member
Author: Christian Behl
Publisher: Springer Science & Business Media
ISBN: 3642451799
Category : Science
Languages : en
Pages : 113
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Book Description
Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.
Author: Konrad Beyreuther
Publisher: Springer Science & Business Media
ISBN: 3642842240
Category : Medical
Languages : en
Pages : 327
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Book Description
Author: Vladimir Titorenko
Publisher: MDPI
ISBN: 3039213555
Category : Science
Languages : en
Pages : 322
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Book Description
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
Author: Pramod C. Rath
Publisher:
ISBN: 9789811335860
Category : Aging
Languages : en
Pages :
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Book Description
This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.
Author: Konrad Beyreuther
Publisher:
ISBN: 9783642842252
Category :
Languages : en
Pages : 216
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Book Description
Author: Leonard Guarente
Publisher: CSHL Press
ISBN: 0879698241
Category : Aging
Languages : en
Pages : 610
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Book Description
This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 438
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Book Description
Author: Naofumi Shiomi
Publisher: BoD – Books on Demand
ISBN: 9535125680
Category : Medical
Languages : en
Pages : 128
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Book Description
Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.
