Molecular Aspects of Host-Pathogen Interactions PDF Download
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Author: Society for General Microbiology. Symposium
Publisher: Cambridge University Press
ISBN: 9780521592154
Category : Medical
Languages : en
Pages : 378
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Book Description
Reports the latest advances in defining the molecular basis of infection in both bacterial and viral systems.
Author: Society for General Microbiology. Symposium
Publisher: Cambridge University Press
ISBN: 9780521592154
Category : Medical
Languages : en
Pages : 378
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Book Description
Reports the latest advances in defining the molecular basis of infection in both bacterial and viral systems.
Author: Archana Singh
Publisher: Springer
ISBN: 9811073716
Category : Science
Languages : en
Pages : 367
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Book Description
The book offers an integrated overview of plant–pathogen interactions. It discusses all the steps in the pathway, from the microbe–host-cell interface and the plant’s recognition of the microbe to the plant’s defense response and biochemical alterations to achieve tolerance / resistance. It also sheds light on the classes of pathogens (bacteria, fungus and viruses); effector molecules, such as PAMPs; receptor molecules like PRRs and NBS-LRR proteins; signaling components like MAPKs; regulatory molecules, such as phytohormones and miRNA; transcription factors, such as WRKY; defense-related proteins such as PR-proteins; and defensive metabolites like secondary metabolites. In addition, it examines the role of post-genomics, high-throughput technology (transcriptomics and proteomics) in studying pathogen outbreaks causing crop losses in a number of plants. Providing a comprehensive picture of plant-pathogen interaction, the updated information included in this book is valuable for all those involved in crop improvement.
Author: Pascale Cossart
Publisher:
ISBN:
Category : Bacterial genomes
Languages : en
Pages : 642
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Book Description
A comprehensive examination of this burgeoning area of important research.
Author: Matthew J. Duncan
Publisher:
ISBN: 9781109909654
Category : Urinary tract infections
Languages : en
Pages : 147
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Book Description
Urinary tract infections are one of the most common bacterial infections in humans and diagnosis and treatment of UTIs among women in the United States alone is the cause for an estimated 8 million office visits per year, and up to 25% of women who experience a first UTI will have a second infection within 6 months. Type 1 fimbriated Escherichia coli represents the most common uropathogen, owing much of its virulence to adherence and invasion of the uroepithelium, mediated by bacterial type 1 fimbriae. Type 1 fimbriae are heteropolymeric organelles of adhesion composed of the tip-located adhesin FimH and a fimbrial shaft. Previously, the specificity of uropathogenic E. coli type 1 fimbriae for the uroepithelium was thought to be mediated by the amino acid structure of FimH, but in these studies, we have demonstrated that the fimbrial shaft also plays a role in determining E. coli type 1 fimbriae-mediated tissue tropism. As well as mediating adherence, E. coli type 1 fimbriae also mediate invasion of the uroepithelium, which could explain the frequent recurrence of E. coli infections of the bladder and their apparent resistance to antibiotic therapy. Using in vitro systems, as well as a mouse model of urinary tract infection, we demonstrated that host cell lipid rafts, which are cholesterol and sphingolipid enriched membrane domains, were required for E. coli uroepithelial invasion. Through this, and the development of an additional model of a lipid raft targeting bacterium, we found that targeting lipid rafts allows bacteria to bypass the barrier function of the mucosal epithelium, and to invade immune cells via a route that avoids the immune cell's bactericidal functions. In summary, we have demonstrated a novel modulator of type 1 fimbrial specificity which allows E. coli to target uroepithelial lipid rafts for invasion. As more and more bacterial pathogens are found to target host cell lipid rafts, the importance of studying bacterial-host cell lipid raft interactions becomes clearer. Understanding the mechanics of these interactions, and the bacterial advantage gained by targeting lipid rafts, could lead to novel therapeutic regimes to treat infections caused by lipid raft targeting pathogens.
Author: Dong Xia
Publisher: Frontiers Media SA
ISBN: 2889714608
Category : Science
Languages : en
Pages : 259
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Book Description
Author: Steffen Rupp
Publisher: Humana Press
ISBN: 9781588298867
Category : Science
Languages : en
Pages : 0
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Book Description
In recent decades, infectious diseases, once believed to be fairly contained, have become a vital, resurgent field of research. In Host-Pathogen Interactions: Methods and Protocols, top experts examine the relationship between the host and the pathogen, crucial in the outcome of an infection and the establishment of disease or asymptomatic, commensal colonization by organisms. The step-by-step laboratory methods and protocols of this volume study host-pathogen interaction, with a focus on fungal, bacterial and parasitic pathogens, at a molecular level in order to reveal the mechanisms of infection and to identify the vulnerabilities of the pathogen of interest. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters feature brief subject introductions, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Host-Pathogen Interactions: Methods and Protocols serves as an easy entry point for all those investigating the factors responsible for the pathogenicity of microorganisms.
Author: M. A. McCrae
Publisher: Cambridge University Press
ISBN: 9780521592154
Category : Science
Languages : en
Pages : 373
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Book Description
An understanding of the relationship between a pathogen and its host is essential for the development of effective disease control measures. This volume focuses on interactions at the molecular level, specifically between the proteins of the infectious agent and the host that has been invaded. Both viral and bacterial systems are considered, with specific examples illustrating the rapid advances being made in defining the molecular mechanisms underlying infection.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Jeremy Brown
Publisher: Academic Press
ISBN: 0124114539
Category : Science
Languages : en
Pages : 483
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Book Description
Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology. It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections. Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases. Provides an updated overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology Helps strengthen interdisciplinary networking and the focus of scientific resources by targeting epidemiology, vaccines, genetics, antibiotic resistance, clonal dissemination, Streptococcus pneumoniae biology, functional genomics, inflammasome, biomarkers, and more Multi-authored by leaders in the field who present a state-of-the-art overview of what the implications are of existing data, and the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections Supports combinatory networking in order to find new solutions in clinical therapies Reflects the most topical pneumococcal research trends
Author: Suresh S. Patil
Publisher: Springer
ISBN: 1461230845
Category : Technology & Engineering
Languages : en
Pages : 271
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Book Description
The field of the molecular basis of plant disease is rapidly developing. The nineteen chapters of current information in Molecular Strategies of Pathogens and Host Plants are written by well known experts in the United States and Japan, and cover recent progress in the genetics and molecular biology of bacteria and fungi which are pathogens of plants. This research emphasizes the genes which are responsible for production of toxins, enzymes, and hormones that lead to pathogenicity and specificity in plant-pathogen interactions. Several chapters also examine the biochemistry of the plant's response to microbial attack.
