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Author: SUSAN. HUBER HOLMES (WOLFGANG.)
Publisher: Cambridge University Press
ISBN: 1108427022
Category : Biometry
Languages : en
Pages : 407
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Book Description
Author: SUSAN. HUBER HOLMES (WOLFGANG.)
Publisher: Cambridge University Press
ISBN: 1108427022
Category : Biometry
Languages : en
Pages : 407
Get Book Here
Book Description
Author: Mark Chang
Publisher: Springer Science & Business Media
ISBN: 144199842X
Category : Medical
Languages : en
Pages : 316
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Book Description
Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
Author: Nan M. Laird
Publisher: Springer Science & Business Media
ISBN: 1441973389
Category : Medical
Languages : en
Pages : 226
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Book Description
This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
Author: Michael Brimacombe
Publisher: CRC Press
ISBN: 0429533233
Category : Mathematics
Languages : en
Pages : 274
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Book Description
This book emphasizes the importance of the likelihood function in statistical theory and applications and discusses it in the context of biology and ecology. Bayesian and frequentist methods both use the likelihood function and provide differing but related insights. This is examined here both through review of basic methodology and also the integr
Author: Raina Robeva
Publisher: Academic Press
ISBN: 0128012714
Category : Mathematics
Languages : en
Pages : 383
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Book Description
Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize specialized software, providing students with much-needed familiarity and experience with computing applications, critical components of the "modern biology" skill set. This book is appropriate for mathematics courses such as finite mathematics, discrete structures, linear algebra, abstract/modern algebra, graph theory, probability, bioinformatics, statistics, biostatistics, and modeling, as well as for biology courses such as genetics, cell and molecular biology, biochemistry, ecology, and evolution. - Examines significant questions in modern biology and their mathematical treatments - Presents important mathematical concepts and tools in the context of essential biology - Features material of interest to students in both mathematics and biology - Presents chapters in modular format so coverage need not follow the Table of Contents - Introduces projects appropriate for undergraduate research - Utilizes freely accessible software for visualization, simulation, and analysis in modern biology - Requires no calculus as a prerequisite - Provides a complete Solutions Manual - Features a companion website with supplementary resources
Author: Alexander Krämer
Publisher: Springer Science & Business Media
ISBN: 0387938354
Category : Medical
Languages : en
Pages : 441
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Book Description
Hardly a day goes by without news headlines concerning infectious disease threats. Currently the spectre of a pandemic of influenza A|H1N1 is raising its head, and heated debates are taking place about the pro’s and con’s of vaccinating young girls against human papilloma virus. For an evidence-based and responsible communication of infectious disease topics to avoid misunderstandings and overreaction of the public, we need solid scientific knowledge and an understanding of all aspects of infectious diseases and their control. The aim of our book is to present the reader with the general picture and the main ideas of the subject. The book introduces the reader to methodological aspects of epidemiology that are specific for infectious diseases and provides insight into the epidemiology of some classes of infectious diseases characterized by their main modes of transmission. This choice of topics bridges the gap between scientific research on the clinical, biological, mathematical, social and economic aspects of infectious diseases and their applications in public health. The book will help the reader to understand the impact of infectious diseases on modern society and the instruments that policy makers have at their disposal to deal with these challenges. It is written for students of the health sciences, both of curative medicine and public health, and for experts that are active in these and related domains, and it may be of interest for the educated layman since the technical level is kept relatively low.
Author: Aubrey Clayton
Publisher: Columbia University Press
ISBN: 0231553358
Category : Mathematics
Languages : en
Pages : 641
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Book Description
There is a logical flaw in the statistical methods used across experimental science. This fault is not a minor academic quibble: it underlies a reproducibility crisis now threatening entire disciplines. In an increasingly statistics-reliant society, this same deeply rooted error shapes decisions in medicine, law, and public policy with profound consequences. The foundation of the problem is a misunderstanding of probability and its role in making inferences from observations. Aubrey Clayton traces the history of how statistics went astray, beginning with the groundbreaking work of the seventeenth-century mathematician Jacob Bernoulli and winding through gambling, astronomy, and genetics. Clayton recounts the feuds among rival schools of statistics, exploring the surprisingly human problems that gave rise to the discipline and the all-too-human shortcomings that derailed it. He highlights how influential nineteenth- and twentieth-century figures developed a statistical methodology they claimed was purely objective in order to silence critics of their political agendas, including eugenics. Clayton provides a clear account of the mathematics and logic of probability, conveying complex concepts accessibly for readers interested in the statistical methods that frame our understanding of the world. He contends that we need to take a Bayesian approach—that is, to incorporate prior knowledge when reasoning with incomplete information—in order to resolve the crisis. Ranging across math, philosophy, and culture, Bernoulli’s Fallacy explains why something has gone wrong with how we use data—and how to fix it.
Author: Jay L. Devore
Publisher: Springer Nature
ISBN: 3030551563
Category : Mathematics
Languages : en
Pages : 981
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Book Description
This 3rd edition of Modern Mathematical Statistics with Applications tries to strike a balance between mathematical foundations and statistical practice. The book provides a clear and current exposition of statistical concepts and methodology, including many examples and exercises based on real data gleaned from publicly available sources. Here is a small but representative selection of scenarios for our examples and exercises based on information in recent articles: Use of the “Big Mac index” by the publication The Economist as a humorous way to compare product costs across nations Visualizing how the concentration of lead levels in cartridges varies for each of five brands of e-cigarettes Describing the distribution of grip size among surgeons and how it impacts their ability to use a particular brand of surgical stapler Estimating the true average odometer reading of used Porsche Boxsters listed for sale on www.cars.com Comparing head acceleration after impact when wearing a football helmet with acceleration without a helmet Investigating the relationship between body mass index and foot load while running The main focus of the book is on presenting and illustrating methods of inferential statistics used by investigators in a wide variety of disciplines, from actuarial science all the way to zoology. It begins with a chapter on descriptive statistics that immediately exposes the reader to the analysis of real data. The next six chapters develop the probability material that facilitates the transition from simply describing data to drawing formal conclusions based on inferential methodology. Point estimation, the use of statistical intervals, and hypothesis testing are the topics of the first three inferential chapters. The remainder of the book explores the use of these methods in a variety of more complex settings. This edition includes many new examples and exercises as well as an introduction to the simulation of events and probability distributions. There are more than 1300 exercises in the book, ranging from very straightforward to reasonably challenging. Many sections have been rewritten with the goal of streamlining and providing a more accessible exposition. Output from the most common statistical software packages is included wherever appropriate (a feature absent from virtually all other mathematical statistics textbooks). The authors hope that their enthusiasm for the theory and applicability of statistics to real world problems will encourage students to pursue more training in the discipline.
Author: F.M. Dekking
Publisher: Springer Science & Business Media
ISBN: 1846281687
Category : Mathematics
Languages : en
Pages : 485
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Book Description
Suitable for self study Use real examples and real data sets that will be familiar to the audience Introduction to the bootstrap is included – this is a modern method missing in many other books
Author: Melinda C. Mills
Publisher: MIT Press
ISBN: 0262357445
Category : Science
Languages : en
Pages : 433
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Book Description
A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.
