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Author: Mark Chang
Publisher: Springer Science & Business Media
ISBN: 144199842X
Category : Medical
Languages : en
Pages : 316
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Book Description
Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
Author: Mark Chang
Publisher: Springer Science & Business Media
ISBN: 144199842X
Category : Medical
Languages : en
Pages : 316
Get Book Here
Book Description
Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
Author: Yaoting Zhang
Publisher: World Scientific
ISBN: 9789812796707
Category : Mathematics
Languages : en
Pages : 304
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Book Description
An interview with Professor Yaoting Zhang / Qiwei Yao and Zhaohai Li -- Significance level in interval mapping / David O. Siegmund and Benny Yakir -- An asymptotic Pythagorean identity / Zhiliang Ying -- A Monte Carlo gap test in computing HPD regions / Ming-Hui Chen [und weitere] -- Estimating restricted normal means using the EM-type algorithms and IBF sampling / Ming Tan, Guo-Liang Tian and Hong-Bin Fang -- An example of algorithm mining: covariance adjustment to accelerate EM and Gibbs / Chuanhai Liu -- Large deviations and deviation inequality for kernel density estimator in L[symbol]-distance / Liangzhen Lei, Liming Wu and Bin Xie -- Local sensitivity analysis of model misspecification / Guobing Lu -- Empirical likelihood confidence intervals for the difference of two quantiles of a population / Yongsong Qin and Yuehua Wu -- Exponential inequalities for spatial processes and uniform convergence rates for density estimation / Qiwei Yao -- A skew regression model for inference of stock volatility / Tuhao J. Chen and Hanfeng Chen -- Explicit transitional dynamics in growth models / Danyang Xie -- A fiscal federalism approach to optimal taxation and intergovernmental transfers in a dynamic model / Liutang Gong and Heng-Fu Zou -- Sharing catastrophe risk under model uncertainty / Xiaodong Zhu -- Ranked set sampling: a methodology for observational economy / Zehua Chen -- Some recent advances on response-adaptive randomized designs / Feifang Hu -- A childhood epidemic model with birthrate-dependent transmission / Yingcun Xia -- Linear regression analysis with observations subject to interval censoring / Linxiong Li -- When can the Haseman-Elston procedure for quantitative trait loci be improved? Insights from optimal design theory / Zhaohai Li, Minyu Xie and Joseph L. Gastwirth -- A semiparametric method for mapping quantitative trait loci / Jian Huang and Kai Wang -- Structure mixture regression models / Hongtu Zhu and Heping Zhang
Author: John M. Lachin
Publisher: John Wiley & Sons
ISBN: 1118625846
Category : Mathematics
Languages : en
Pages : 676
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Book Description
Praise for the First Edition ". . . an excellent textbook . . . an indispensable reference for biostatisticians and epidemiologists." —International Statistical Institute A new edition of the definitive guide to classical and modern methods of biostatistics Biostatistics consists of various quantitative techniques that are essential to the description and evaluation of relationships among biologic and medical phenomena. Biostatistical Methods: The Assessment of Relative Risks, Second Edition develops basic concepts and derives an expanded array of biostatistical methods through the application of both classical statistical tools and more modern likelihood-based theories. With its fluid and balanced presentation, the book guides readers through the important statistical methods for the assessment of absolute and relative risks in epidemiologic studies and clinical trials with categorical, count, and event-time data. Presenting a broad scope of coverage and the latest research on the topic, the author begins with categorical data analysis methods for cross-sectional, prospective, and retrospective studies of binary, polychotomous, and ordinal data. Subsequent chapters present modern model-based approaches that include unconditional and conditional logistic regression; Poisson and negative binomial models for count data; and the analysis of event-time data including the Cox proportional hazards model and its generalizations. The book now includes an introduction to mixed models with fixed and random effects as well as expanded methods for evaluation of sample size and power. Additional new topics featured in this Second Edition include: Establishing equivalence and non-inferiority Methods for the analysis of polychotomous and ordinal data, including matched data and the Kappa agreement index Multinomial logistic for polychotomous data and proportional odds models for ordinal data Negative binomial models for count data as an alternative to the Poisson model GEE models for the analysis of longitudinal repeated measures and multivariate observations Throughout the book, SAS is utilized to illustrate applications to numerous real-world examples and case studies. A related website features all the data used in examples and problem sets along with the author's SAS routines. Biostatistical Methods, Second Edition is an excellent book for biostatistics courses at the graduate level. It is also an invaluable reference for biostatisticians, applied statisticians, and epidemiologists.
Author: Mark Chang
Publisher: CRC Press
ISBN: 1351214535
Category : Medical
Languages : en
Pages : 376
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Book Description
"This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.
Author: Ramakrishna HK
Publisher: Springer
ISBN: 9811019231
Category : Medical
Languages : en
Pages : 188
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Book Description
This book deals with statistics in medicine in a simple way. The text is supported by abundant examples from medical data. This book aims to explain and simplify the process of data presentation. Further aspects addressed include how to design and conduct clinical trials, and how to write journal articles.
Author: Wayne W. Daniel
Publisher: John Wiley & Sons
ISBN: 1119282373
Category : Medical
Languages : en
Pages : 720
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Book Description
The ability to analyze and interpret enormous amounts of data has become a prerequisite for success in allied healthcare and the health sciences. Now in its 11th edition, Biostatistics: A Foundation for Analysis in the Health Sciences continues to offer in-depth guidance toward biostatistical concepts, techniques, and practical applications in the modern healthcare setting. Comprehensive in scope yet detailed in coverage, this text helps students understand—and appropriately use—probability distributions, sampling distributions, estimation, hypothesis testing, variance analysis, regression, correlation analysis, and other statistical tools fundamental to the science and practice of medicine. Clearly-defined pedagogical tools help students stay up-to-date on new material, and an emphasis on statistical software allows faster, more accurate calculation while putting the focus on the underlying concepts rather than the math. Students develop highly relevant skills in inferential and differential statistical techniques, equipping them with the ability to organize, summarize, and interpret large bodies of data. Suitable for both graduate and advanced undergraduate coursework, this text retains the rigor required for use as a professional reference.
Author: Måns Thulin
Publisher:
ISBN: 9781032497457
Category : Mathematics
Languages : en
Pages : 0
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Book Description
The past decades have transformed the world of statistical data analysis, with new methods, new types of data, and new computational tools. Modern Statistics with R introduces you to key parts of this modern statistical toolkit. It teaches you: Data wrangling - importing, formatting, reshaping, merging, and filtering data in R. Exploratory data analysis - using visualisations and multivariate techniques to explore datasets. Statistical inference - modern methods for testing hypotheses and computing confidence intervals. Predictive modelling - regression models and machine learning methods for prediction, classification, and forecasting. Simulation - using simulation techniques for sample size computations and evaluations of statistical methods. Ethics in statistics - ethical issues and good statistical practice. R programming - writing code that is fast, readable, and (hopefully!) free from bugs. No prior programming experience is necessary. Clear explanations and examples are provided to accommodate readers at all levels of familiarity with statistical principles and coding practices. A basic understanding of probability theory can enhance comprehension of certain concepts discussed within this book. In addition to plenty of examples, the book includes more than 200 exercises, with fully worked solutions available at: www.modernstatisticswithr.com.
Author: Gary L Rosner
Publisher: CRC Press
ISBN: 1000353001
Category : Mathematics
Languages : en
Pages : 822
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Book Description
Praise for Bayesian Thinking in Biostatistics: "This thoroughly modern Bayesian book ...is a 'must have' as a textbook or a reference volume. Rosner, Laud and Johnson make the case for Bayesian approaches by melding clear exposition on methodology with serious attention to a broad array of illuminating applications. These are activated by excellent coverage of computing methods and provision of code. Their content on model assessment, robustness, data-analytic approaches and predictive assessments...are essential to valid practice. The numerous exercises and professional advice make the book ideal as a text for an intermediate-level course..." -Thomas Louis, Johns Hopkins University "The book introduces all the important topics that one would usually cover in a beginning graduate level class on Bayesian biostatistics. The careful introduction of the Bayesian viewpoint and the mechanics of implementing Bayesian inference in the early chapters makes it a complete self- contained introduction to Bayesian inference for biomedical problems....Another great feature for using this book as a textbook is the inclusion of extensive problem sets, going well beyond construed and simple problems. Many exercises consider real data and studies, providing very useful examples in addition to serving as problems." - Peter Mueller, University of Texas With a focus on incorporating sensible prior distributions and discussions on many recent developments in Bayesian methodologies, Bayesian Thinking in Biostatistics considers statistical issues in biomedical research. The book emphasizes greater collaboration between biostatisticians and biomedical researchers. The text includes an overview of Bayesian statistics, a discussion of many of the methods biostatisticians frequently use, such as rates and proportions, regression models, clinical trial design, and methods for evaluating diagnostic tests. Key Features Applies a Bayesian perspective to applications in biomedical science Highlights advances in clinical trial design Goes beyond standard statistical models in the book by introducing Bayesian nonparametric methods and illustrating their uses in data analysis Emphasizes estimation of biomedically relevant quantities and assessment of the uncertainty in this estimation Provides programs in the BUGS language, with variants for JAGS and Stan, that one can use or adapt for one's own research The intended audience includes graduate students in biostatistics, epidemiology, and biomedical researchers, in general Authors Gary L. Rosner is the Eli Kennerly Marshall, Jr., Professor of Oncology at the Johns Hopkins School of Medicine and Professor of Biostatistics at the Johns Hopkins Bloomberg School of Public Health. Purushottam (Prakash) W. Laud is Professor in the Division of Biostatistics, and Director of the Biostatistics Shared Resource for the Cancer Center, at the Medical College of Wisconsin. Wesley O. Johnson is professor Emeritus in the Department of Statistics as the University of California, Irvine.
Author: Eric Vittinghoff
Publisher: Springer Science & Business Media
ISBN: 1461413524
Category : Education
Languages : en
Pages : 526
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Book Description
This fresh edition, substantially revised and augmented, provides a unified, in-depth, readable introduction to the multipredictor regression methods most widely used in biostatistics. The examples used, analyzed using Stata, can be applied to other areas.
Author: Lemuel A. Moye
Publisher: CRC Press
ISBN: 1584887257
Category : Mathematics
Languages : en
Pages : 400
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Book Description
Bayesian analyses have made important inroads in modern clinical research due, in part, to the incorporation of the traditional tools of noninformative priors as well as the modern innovations of adaptive randomization and predictive power. Presenting an introductory perspective to modern Bayesian procedures, Elementary Bayesian Biostatistics explo
