Modeling of Auditory Nerve Responses to Electrical Stimulation PDF Download
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Author: Konstantina M. Trbovic
Publisher:
ISBN:
Category :
Languages : en
Pages : 176
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Author: Konstantina M. Trbovic
Publisher:
ISBN:
Category :
Languages : en
Pages : 176
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Book Description
Author: Yoojin Chung
Publisher:
ISBN:
Category :
Languages : en
Pages : 320
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Book Description
Abstract: Bilateral cochlear implants (BiCIs) are becoming more common recently and have been proven to provide improvements in speech perception in noise and sound localization. However, benefits to sound localization for BiCI listening are mainly from the perception of interaural level differences while interaural time difference (ITD) sensitivity is very limited. To help understand this, the current modeling study focused on the following characteristics of neurophysiological data from ITD-sensitive neurons in acutely deafened animal models with BiCIs: (1) rate-limitation of ITD sensitivity to constant-amplitude pulse trains, (2) intensity dependence of ITD sensitivity, and (3) effect of amplitude modulation on ITD sensitivity with high-rate stimulation. A network of model neurons was used to study binaural responses to electrical stimulation. Our working hypothesis was that central auditory processing is normal so that the abnormality in the response to the electric stimulation at the level of the auditory nerve fibers (ANFs) is the source of the limited binaural response. A descriptive model of ANF response to electric stimulation was implemented and used as an input to a network of model neurons in the ascending auditory pathway, up to the inferior colliculus (IC). The result shows that ITD sensitivity depends strongly on the specific configurations of membrane and synaptic parameters for different input stimulation rates. Stronger excitatory synaptic inputs and a faster membrane response are required for the model neurons to be ITD-sensitive at high stimulation rates, both in electric and acoustic stimulation. This raises the possibility of frequency-dependent differences in neural mechanisms of binaural processing; limitations in ITD sensitivity may be due to the mismatch between stimulation rate and cell parameters in ITD-sensitive neurons. The high spike rate and phase-locking at the ANF to electric stimulation changes the rate-ITD tuning at the IC. Amplitude modulation of the high-rate stimulation restores the ongoing ITD sensitivity by effectively reducing the spike rate in the ANF. ITD sensitivity to temporal fine-structure is restored in the model with amplitude-modulated high-rate stimulation, consistent with physiological results. Overall, this study suggests that fine-structure ITD can be delivered to BiCI users with proper processing strategies.
Author: Joseph M. Miller
Publisher: Springer Science & Business Media
ISBN: 1461232562
Category : Medical
Languages : en
Pages : 416
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Book Description
This volume describes a new direction in technological and biomedical developments for profoundly deaf individuals. The first section covers topics of tissue characteristics, such as responses to electrical stimulation and computer modelling of cochlea currents. Perception of acoustic signals, responses and behavioral pattern as well as psychophysical aspects are treated in the second part. Part III is addressed to perspectives and challenges of encoding schemes. Reports on studies of acoustic and electrical encoding of temporal information, speech features with cochlear implants as well as psychophysical and speech perceptual studies will allow further strategies for cochlea implants.
Author: Pim van Dijk
Publisher: Springer
ISBN: 331925474X
Category : Medical
Languages : en
Pages : 487
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Book Description
The International Symposium on Hearing is a prestigious, triennial gathering where world-class scientists present and discuss the most recent advances in the field of human and animal hearing research. The 2015 edition will particularly focus on integrative approaches linking physiological, psychophysical and cognitive aspects of normal and impaired hearing. Like previous editions, the proceedings will contain about 50 chapters ranging from basic to applied research, and of interest to neuroscientists, psychologists, audiologists, engineers, otolaryngologists, and artificial intelligence researchers.
Author: Paul F. Poon
Publisher: Springer Science & Business Media
ISBN: 1461553512
Category : Medical
Languages : en
Pages : 507
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Book Description
The full power of combining experiment and theory has yet to be unleashed on studies of the neural mechanisms in the brain involved in acoustic information processing. In recent years, enormous amounts of physiological data have been generated in many laboratories around the world, characterizing electrical responses of neurons to a wide array of acoustic stimuli at all levels of the auditory neuroaxis. Modern approaches of cellular and molecular biology are leading to new understandings of synaptic transmission of acoustic information, while application of modern neuro-anatomical methods is giving us a fairly comprehensive view ofthe bewildering complexity of neural circuitry within and between the major nuclei of the central auditory pathways. Although there is still the need to gather more data at all levels of organization, a ma jor challenge in auditory neuroscience is to develop new frameworks within which existing and future data can be incorporated and unified, and which will guide future laboratory ex perimentation. Here the field can benefit greatly from neural modeling, which in the central auditory system is still in its infancy. Indeed, such an approach is essential if we are to address questions related to perception of complex sounds including human speech, to the many di mensions of spatial hearing, and to the mechanisms that underlie complex acoustico-motor behaviors.
Author: Xisha Chen
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Frank Rattay
Publisher: Springer Science & Business Media
ISBN: 3709132711
Category : Technology & Engineering
Languages : en
Pages : 266
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Book Description
Functional electrical stimulation is the most important application in the field of clinical treatment with currents or magnetism. This technique artificially generates neural activity in order to overcome lost functions of the paralized, incontinent or sensory handicapped patient. Electricity and magnetism is also used in many cases, e.g., to stimulate bone growth or wound healing. Nevertheless, the basic mechanism of the artificial excitation of nerve and muscle fibers has become known only in the last few years. Although many textbooks are concerned with the natural excitation process there is a lack of information on the influence of an applied electrical or magnetic field. This book, written for students and biomedical engineers, should close the gap and, furthermore, it should stimulate the design of new instrumentation using optimal strategies.
Author: Fan-Gang Zeng
Publisher: Springer Science & Business Media
ISBN: 0387225854
Category : Science
Languages : en
Pages : 448
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Book Description
Cochlear implants have instigated a popular but controversial revolution in the treatment of deafness. This book discusses the physiological bases of using artificial devices to electrically stimulate the brain to interpret sounds. As the first successful device to restore neural function, the cochlear implant serves as a model for research in neuroscience and biomedical engineering. These and other auditory prostheses are discussed in the context of historical treatments, engineering, psychophysics and clinical issues as well as implications for speech, behavior, cognition and long-term effects on people.
Author: Charles-André Haenggeli
Publisher:
ISBN:
Category :
Languages : en
Pages : 176
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Book Description
Ce travail révèle aussi l'intérêt de notre modèle animal pour l'approche de certaines questions cliniques relevant du domaine des implants cochléaires.
Author: Lisa Marie Montney
Publisher:
ISBN:
Category :
Languages : en
Pages : 392
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Book Description
