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Author: Paul J. Brindley
Publisher: CRC Press
ISBN: 1498712886
Category : Science
Languages : en
Pages : 138
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Book Description
Substantial proportions of the genome of most eukaryotes, including those of metazoan parasites, are comprised of repetitive sequences. Mobile genetic elements (MGEs) constitute much of the repetitive component, particularly the interspersed sequences. This volume of nine chapters addresses MGEs that have colonized the genomes of medically important metazoan parasites and their vectors. These MGEs are parasites of parasites. These mobile elements are compared and contrasted with those from better-studied model organisms. The authors have included plentiful, relevant, and informative illustrations and references. Several chapters focus on mobile elements of the human schistosomes. Gerardo Ferbeyre focuses on the putative ribozyme activities on the SM alpha elements, SINE-like elements, including trans reactions catalyzed by these retroposons. Ricardo DeMarco and Sergio Verjovski-Almeida review the cut-and-paste transposons of schistosomes, including the Merlin and the SmTRC1 elements, and application of schistosome DNA transposons to transgenesis and mutagenesis. Claudia Copeland, Thewarach Laha and I review the retrovirus-like retrotransposons and non-long terminal repeat transposable elements of the schistosomes, including the Boudicca, fugitive and SR2 elements. Young-An Bae and Yoon Kong provide descriptions of retrotransposons from the human liver and lung flukes, Clonorchis sinensis and Paragonimus westermani, respectively, including the CsRn1 long terminal repeat retrotransposon. Continuing the investigations of MGEs of parasitic worms, Thewarach Laha, Alex Loukas and I summarize current knowledge of MGEs from hookworms, including details of the bandit and Transib transposons and dingo retrotransposons. Mobile elements in vectors of human parasites are also covered. Matty Knight and coauthors describe the nimbus retrotransposon and its discovery and other repetitive elements from the genome of the gastropod snail Biomphalaria glabrata, the intermediate host of Schistosoma mansoni. Zhijian Tu and Song Ti review MGEs of Anopheles mosquitoes, vectors of malaria, and other mosquitoes. They discuss practical uses of these MGEs. Craig Coates provides an expert article on transposon mediated transgenesis of mosquitoes, in particular dealing with his pioneering studies on the deployment of binary systems with the Mos1 mariner transposon. MGEs from the genomes of these metazoan parasites have practical uses in transgenesis and epidemiological studies and also are valuable for annotation of the genomes of these vectors and pathogens. These issues and future directions are well covered in these chapters.
Author: Paul J. Brindley
Publisher: CRC Press
ISBN: 1498712886
Category : Science
Languages : en
Pages : 138
Get Book Here
Book Description
Substantial proportions of the genome of most eukaryotes, including those of metazoan parasites, are comprised of repetitive sequences. Mobile genetic elements (MGEs) constitute much of the repetitive component, particularly the interspersed sequences. This volume of nine chapters addresses MGEs that have colonized the genomes of medically important metazoan parasites and their vectors. These MGEs are parasites of parasites. These mobile elements are compared and contrasted with those from better-studied model organisms. The authors have included plentiful, relevant, and informative illustrations and references. Several chapters focus on mobile elements of the human schistosomes. Gerardo Ferbeyre focuses on the putative ribozyme activities on the SM alpha elements, SINE-like elements, including trans reactions catalyzed by these retroposons. Ricardo DeMarco and Sergio Verjovski-Almeida review the cut-and-paste transposons of schistosomes, including the Merlin and the SmTRC1 elements, and application of schistosome DNA transposons to transgenesis and mutagenesis. Claudia Copeland, Thewarach Laha and I review the retrovirus-like retrotransposons and non-long terminal repeat transposable elements of the schistosomes, including the Boudicca, fugitive and SR2 elements. Young-An Bae and Yoon Kong provide descriptions of retrotransposons from the human liver and lung flukes, Clonorchis sinensis and Paragonimus westermani, respectively, including the CsRn1 long terminal repeat retrotransposon. Continuing the investigations of MGEs of parasitic worms, Thewarach Laha, Alex Loukas and I summarize current knowledge of MGEs from hookworms, including details of the bandit and Transib transposons and dingo retrotransposons. Mobile elements in vectors of human parasites are also covered. Matty Knight and coauthors describe the nimbus retrotransposon and its discovery and other repetitive elements from the genome of the gastropod snail Biomphalaria glabrata, the intermediate host of Schistosoma mansoni. Zhijian Tu and Song Ti review MGEs of Anopheles mosquitoes, vectors of malaria, and other mosquitoes. They discuss practical uses of these MGEs. Craig Coates provides an expert article on transposon mediated transgenesis of mosquitoes, in particular dealing with his pioneering studies on the deployment of binary systems with the Mos1 mariner transposon. MGEs from the genomes of these metazoan parasites have practical uses in transgenesis and epidemiological studies and also are valuable for annotation of the genomes of these vectors and pathogens. These issues and future directions are well covered in these chapters.
Author:
Publisher:
ISBN: 9781433711633
Category : Host-parasite relationships
Languages : en
Pages : 123
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Book Description
Substantial proportions of the genome of most eukaryotes, including those of metazoan parasites, are comprised of repetitive sequences. Mobile genetic elements (MGEs) constitute much of the repetitive component, particularly the interspersed sequences. This volume of nine chapters addresses MGEs that have colonized the genomes of medically important metazoan parasites and their vectors. These MGEs are parasites of parasites. These mobile elements are compared and contrasted with those from better-studied model organisms. The authors have included plentiful, relevant, and informative illustrati.
Author: W. Evan Secor
Publisher: Springer Science & Business Media
ISBN: 0387233628
Category : Science
Languages : en
Pages : 242
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Book Description
Human schistosomiasis is a disease with a rich and well-documented past, and every expectation of an unfortunately long future. These infections were known to the ancient Egyptians and their transmission shows little evidence of slowing down, globally. The good news is that field applicable, and increasingly affordable, chemotherapy has been available for almost 25 years. Using chemotherapy and other means of control, some countries have decreased transmission and made excellent headway against morbidity. The bad news is that the public health problems caused by schistosomiasis are still with us, with the estimated number of cases of schistosomiasis, while shifting geographically, remaining approximately 200 million for the last 30 years. In fact, with the development of field usable ultrasound technology and meta-analyses performed on existing data, there is a new appreciation for the extent of non-lethal morbidity associated with these infections. While the percentage of individuals with severe hepatosplenic disease remains below 10%, recent reassessments of morbidity associated with schistosomiasis indicate that the prevelance of symptoms and the cost in diability-adjusted life years is much greater than was previously, commonly appreciated (Van der Werf, M. J. , et al. 2003, Acta Tropica 86:125-139; Charles H. King, personnel communication). Strong impetus for addressing these issues is provided by the World Health Assembly’s recently passed Resolution 54. 19, which calls for efforts to reduce morbidity caused by schistosomiasis and soil-transmitted helminths in school-aged children, largely through chemotherapy campaigns.
Author: Aaron G. Maule
Publisher: CABI
ISBN: 0851990274
Category : Medical
Languages : en
Pages : 468
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Book Description
This book examines recent research into the molecular biology, genomics and transcriptomics of, and novel control strategies for, flatworm parasites. These include Cestodes (tapeworms) and Trematodes (flukes, schistosomes etc), which are the cause of a number of diseases of medical and veterinary importance. The book explores three main areas: phylogeny, genetics and transcriptomes; immunobiology, host-parasite interaction and control; and protein function, metabolism and physiology. Where appropriate, comparisons are made between different parasitic flatworms and between parasitic and free-living species. The book concludes by exploring future avenues for research. Contributors to the book include leading authorities from Europe, North and South America, and Australia.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 2214
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author:
Publisher: Editora E-papers
ISBN: 8587922882
Category :
Languages : en
Pages : 455
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Book Description
Author: Jose F. Tort
Publisher: Frontiers Media SA
ISBN: 2889660702
Category : Medical
Languages : en
Pages : 169
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Kenneth Söderhäll
Publisher: Springer Science & Business Media
ISBN: 1441980598
Category : Medical
Languages : en
Pages : 338
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Book Description
It can be seen that the insects are the still attracting most research and researchers. However, an increasing interest is emerging to study new invertebrate groups, especially those where the genome is known. Even though Drosophila has been and still is an excellent model for immune studies, it is now clear that there are great differences between immune responses in Drosophila and that of several other invertebrates, which indeed calls for more research on other invertebrates
Author:
Publisher: National Academies Press
ISBN: 030921839X
Category :
Languages : en
Pages : 538
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Book Description
Author: George C. Prendergast
Publisher: John Wiley & Sons
ISBN: 9780471432029
Category : Science
Languages : en
Pages : 370
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Book Description
Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.
