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Author: F.D.K. Liddell
Publisher: CRC Press
ISBN: 9780849366468
Category : Science
Languages : en
Pages : 398
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Book Description
The part of this book covering pathogensis and modes of action begins with a chapter on the physicochemical properties of asbestos fibers and a chapter on the deposition and retention of fibers within the lung and their clearance. Some of the effects of asbestos can be reproduced in animal experiments, and the book includes a full review of the results from animal studies using various routes of administration of fibers. It is also generally accepted that the effects of fibers on pulmonary macrophages is central to all fiber-induced pathology, and the release of macrophage-associated inflammatory and immunological mediatros is dealt with in a further chapter. Examination of pathogenicity by cell culture is described, and areas covered include the role of free radicals and cellular mechanisms in producing genetic damage. The fiber-induced activation of some second messenger pathways is also described, with consideration of whether or not similar cellular mechanisms are responsible for all the clinical conditions associated with fiber exposure. Knowledge of the mechanisms involved should be valuable in the development of safe fibers and the prevention of human exposure to new materials that are dangerous as asbestos. The final chapters expound and resolve the conflicts in evidence, discuss the importance of fibers for human well-being and the possible health impact on nonmineral alternatives, and evaluate risks to the public
Author: F.D.K. Liddell
Publisher: CRC Press
ISBN: 9780849366468
Category : Science
Languages : en
Pages : 398
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Book Description
The part of this book covering pathogensis and modes of action begins with a chapter on the physicochemical properties of asbestos fibers and a chapter on the deposition and retention of fibers within the lung and their clearance. Some of the effects of asbestos can be reproduced in animal experiments, and the book includes a full review of the results from animal studies using various routes of administration of fibers. It is also generally accepted that the effects of fibers on pulmonary macrophages is central to all fiber-induced pathology, and the release of macrophage-associated inflammatory and immunological mediatros is dealt with in a further chapter. Examination of pathogenicity by cell culture is described, and areas covered include the role of free radicals and cellular mechanisms in producing genetic damage. The fiber-induced activation of some second messenger pathways is also described, with consideration of whether or not similar cellular mechanisms are responsible for all the clinical conditions associated with fiber exposure. Knowledge of the mechanisms involved should be valuable in the development of safe fibers and the prevention of human exposure to new materials that are dangerous as asbestos. The final chapters expound and resolve the conflicts in evidence, discuss the importance of fibers for human well-being and the possible health impact on nonmineral alternatives, and evaluate risks to the public
Author: Victor L. Roggli
Publisher: Springer Science & Business Media
ISBN: 038721819X
Category : Medical
Languages : en
Pages : 437
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Book Description
Pathology of Asbestos-Associated Diseases integrates the newest research and advances in its discussion of asbestos-induced diseases. Organized in 13 chapters, the book begins with background information on the mineralogy of asbestos, occupation and environmental exposure to asbestos, and asbestosis. A detailed discussion on mesothelioma includes a historical background, addresses etiologic considerations and epidemiology, pathologic features, differential diagnosis and treatment and prognosis. Guidelines for assessing and identifying asbestos-associated carcinomas of the lung, including histopathology and differential diagnosis, are discussed. The text also addresses the explosion of research in the area of molecular biology and the abundance of information bearing on the mechanisms by which asbestos causes disease. Chapters also cover cytopathology and experimental models of asbestos-related diseases. The diseases associated with asbestos have significant medico-legal implications, and there are two chapters dedicated to addressing the issue. More than 190 illustrations complement the text. An invaluable reference for the pathologist, pulmonologist, radiologist, and occupational medical practitioner interested in asbestos-related disease as well as malpractice attorneys needing an understanding of asbestos, the diseases it induces, prognosis and clinical implications.
Author: Committee on Nonoccupational Health Risks of Asbestiform Fibers
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 356
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Book Description
Much of the more than 30 million tons of asbestos used in the United States since 1900 is still present as insulation in offices and schools, as vinyl-asbestos flooring in homes, and in other common products. This volume presents a comprehensive evaluation of the relation of these fibers to specific diseases and the extent of nonoccupational risks associated with them. It covers sources of asbestiform fibers, properties of the fibers, and carcinogenic and fibrogenic risks they pose.
Author: Morton Lippmann
Publisher: John Wiley & Sons
ISBN: 0470442883
Category : Science
Languages : en
Pages : 1189
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Book Description
Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
ISBN: 9283212819
Category : Medical
Languages : en
Pages : 434
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Book Description
"This publication represents the views and expert opinions of an IARC working group on the evaluation of carcinogenic risks to humans, which met in Lyon, 9-16 October 2001."
Author: George D. Guthrie, Jr.
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 1501509713
Category : Science
Languages : en
Pages : 600
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Book Description
Volume 28 of Reviews in Mineralogy provides some of the necessary tools for the researcher interested in this area of interdisciplinary research. The chapters present several of the important problems, concepts, and approaches from both the geological and biological ends of the spectrum. These two extremes are partially integrated throughout the book by cross-referencing between chapters. Chapter 1 also presents a general introduction into the ways in which these two areas overlap. However, many of the areas ripe for the interdisciplinarian will become obvious after reading the various chapters. The final chapter of this book discusses some of the regulatory aspects of minerals. Ultimately, the regulatory arena is where this type of interdisciplinary approach can make an impact, and hopefully better communication between all parties will accomplish this goal. A glossary is included at the end of this book, because the complexity of scientific terms in the two fields can thwart even the most enthusiastic of individuals. This volume represents the proceedings of a course by the same title held at Harbor House Resort and Conference Center on Nantucket Island off the coast of Massachusetts, October 22-24, 1993.
Author: Rosalind Dalefield
Publisher: Elsevier
ISBN: 0127999124
Category : Medical
Languages : en
Pages : 630
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Book Description
Veterinary Toxicology for Australia and New Zealand is a reference suited to the unique challenges of veterinary practice in Australia and New Zealand. Both streamlined and thorough in its coverage of poisons and treatments for those locations, this focused approach allows readers to quickly find relevant information that is presented in a concise and logical manner that is useful to clinicians. The authors draw upon a wealth of knowledge of the particularities of toxicology in Australia and New Zealand to present readers with the up-to-date information required to efficiently and effectively diagnose and treat their patients. - Highlights toxins of specific concern in Australia and New Zealand - Structures information in a logical way so that it can be located quickly - Offers up-to-date information on current and emerging risks
Author: Andrey Korchevskiy
Publisher: John Wiley & Sons
ISBN: 111943842X
Category : Technology & Engineering
Languages : en
Pages : 485
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Book Description
Evaluates the risks and human health impacts of asbestos and other fibrous minerals Despite continuous efforts to eliminate asbestos from commercial use, it remains a serious occupational and environmental hazard. Health Risk Assessment for Asbestos and Other Fibrous Minerals provides a rigorous discussion of risk assessment methodology for elongate mineral particles, covering basics, theory, models, and practical applications, enabling readers to participate in carrying out efficient and informed health risk assessments, to estimate potential adverse effects for exposed populations, and to determine the acceptability of risks at a given level of exposure. Coverage includes: Mineralogy, health effects, pathology, exposure assessment, modeling, and characterization of risks for asbestos and similar toxic materials Necessary integration of epidemiology, toxicology, industrial hygiene, and environmental health expertise when performing a health risk assessment Emerging and not-well-known hazards, e.g. erionite and other naturally occurring fibrous minerals Contributions by Garry Burdett, Bruce Case, Lucy Darnton, Daniel Hall, Arseniy Korchevskiy, Brooke Mossman, Cassidy Strode, Robert Strode, and Ann Wylie Case studies and examples of risk calculations Health Risk Assessment for Asbestos and Other Fibrous Minerals is a highly practical reference on the subject for occupational and public health professionals, industry and government regulators, industrial hygienists, and risk assessors, along with epidemiologists, biostatisticians, toxicologists, and other scientific professionals.
Author: J. Descotes
Publisher: Elsevier
ISBN: 0080534228
Category : Technology & Engineering
Languages : en
Pages : 859
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Book Description
This excellent volume was designed and edited with two major ideas in mind: firstly, the field of clinical toxicology is changing and an acknowledgement of these changes is warranted; secondly, no comprehensive compilation of recently published case reports of, and clinical studies on, human poisonings is available, which is in sharp contrast to the closely related field of drug-induced side-effects.The book focusses on issues of recent concern, or issues poorly documented in the past. It is important that clinical toxicologists gain a better knowledge of all the available techniques of toxicological analysis. A better understanding of the way a sound interpretation of results should be conducted for the benefit of the patient's management, and a comprehensive set of data on the kinetics of the most common pharmaceutical drugs and many chemicals is required.Human Toxicology is a timely reference work which will be welcomed by a broad audience of toxicology professionals.
Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 1162
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Book Description
