Mass Spectrometry in the Analysis of Large Molecules PDF Download
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Author: Catherine McNeal
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 240
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Book Description
Ten lectures plus several contributions examine the progress made in the analysis of large molecules of m/z 10,000 and beyond. Explores how to apply this technology and ways of extending the analysis to even higher masses. Also examines how mass spectrometry techniques fit in with existing chemical and biochemical methods of structure analysis.
Author: Catherine McNeal
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 240
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Book Description
Ten lectures plus several contributions examine the progress made in the analysis of large molecules of m/z 10,000 and beyond. Explores how to apply this technology and ways of extending the analysis to even higher masses. Also examines how mass spectrometry techniques fit in with existing chemical and biochemical methods of structure analysis.
Author: Ragu Ramanathan
Publisher: John Wiley & Sons
ISBN: 111821157X
Category : Science
Languages : en
Pages : 326
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Book Description
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Author: John Dennis Lennon
Publisher:
ISBN:
Category : Mass spectrometry
Languages : en
Pages : 302
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Book Description
Author: Michael L. Gross
Publisher: John Wiley & Sons
ISBN: 1118116542
Category : Medical
Languages : en
Pages : 484
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Book Description
The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.
Author: Sergio Facchetti
Publisher: Elsevier Publishing Company
ISBN:
Category : Science
Languages : en
Pages : 344
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Book Description
Author: Oscar Alzate
Publisher: CRC Press
ISBN: 1420076264
Category : Medical
Languages : en
Pages : 356
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Book Description
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Author: Eberhard R Hilf
Publisher: World Scientific
ISBN: 9814506885
Category : Science
Languages : en
Pages : 251
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Book Description
This is a coherent collection of thoroughly written articles on the present status of new mass spectrometry methods. PDMS and LDMS, Plasma Desorption and Laser Desorption Mass Spectrometry, are ideal for application in Biology. This volume is the first coherent edition devoted to applications in Marine Organic Chemistry.
Author: Nader Rifai
Publisher: Elsevier
ISBN: 0128160640
Category : Science
Languages : en
Pages : 218
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Book Description
Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
A mass spectrometer determines the mass of multiply charged high molecular weight molecules. This spectrometer utilizes an ion detector which is capable of simultaneously measuring the charge z and transit time of a single ion as it passes through the detector. From this transit time, the velocity of the single ion may then be derived, thus providing the mass-to-charge ratio m/z for a single ion which has been accelerated through a known potential. Given z and m/z, the mass m of the single ion can then be calculated. Electrospray ions with masses in excess of 1 MDa and charge numbers greater than 425 e.sup.- are readily detected. The on-axis single ion detection configuration enables a duty cycle of nearly 100% and extends the practical application of electrospray mass spectrometry to the analysis of very large molecules with relatively inexpensive instrumentation.
Author: Pietro Traldi
Publisher: John Wiley & Sons
ISBN: 0470025182
Category : Science
Languages : en
Pages : 152
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Book Description
This text presents the information needed to design a successful quantitative analysis using mass spectrometric techniques currently available and widely employed. It is devoted to the researchers of different areas, who use mass spectrometry as a detector suitable for the measurements of their interest. An essential book for the practicing mass spectroscopist A genuine 'how-to' text for the practitioner focusing on quantification rather than instrumental design and techniques Up-to-date structured text describing methods, experimental strategy, capabilities and limitations, with data analysis and interpretation Brings together material widely dispersed in the pertinent literature into one unique source Internationally recognized group of authors
